Noncausal effects of genetic predicted depression and gastric cancer risk: A NHANES and Mendelian randomization study DOI Creative Commons
Juanjuan Liu,

Yue hong Chen,

Pai qi Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

Abstract The relationship between gastric cancer and depression remains an area of active investigation, with recent studies suggesting a potential bidirectional association. We present analysis the correlation using data from National Health Nutrition Examination Survey (NHANES) Genome-Wide Association Studies (GWAS), employing Mendelian Randomization (MR) to explore causal links these conditions. NHANES adjusted for confounders such as lifestyle factors pre-existing health conditions, revealing higher incidence among individuals cancer. Stepwise regression models further established risk factor developing Conversely, MR genetic variants instrumental variables suggested that significantly impacts development depression, 24 single nucleotide polymorphisms (SNPs) showing significant association both Inverse Variance Weighted (IVW) method indicated effect on (OR: 0.979[0.962-0.995]), although strength varied different weighting methods. Reverse did not find impact occurrence cancer, 15 SNPs associated diseases but no observed 0.834 [0.504-1.380]). study's findings underscore importance considering mental well-being in treatment provide new direction future therapeutic approaches. However, limitations focus European ancestry lack specificity regarding types warrant research.

Language: Английский

Traditional Chinese medicine for the treatment of cancers of hepatobiliary system: from clinical evidence to drug discovery DOI Creative Commons
Junyu Wu, Guping Tang, Chien‐shan Cheng

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 1, 2024

Language: Английский

Citations

7
Host-microbiota interactions in collagen-induced arthritis rats treated with human umbilical cord mesenchymal stem cell exosome and ginsenoside Rh2 DOI Open Access

Zhongsheng Zhou,

Yang Li,

Shuhui Wu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116515 - 116515

Published: April 2, 2024

Mesenchymal stem cell exosome (MSCs-exo) is a class of products secreted by mesenchymal cells (MSCs) that contain various biologically active substances. MSCs-exo promising alternative to MSCs due their lower immunogenicity and lack ethical constraints. Ginsenoside Rh2 (Rh2) hydrolyzed component the primary substance ginsenosides. has variety pharmacological functions, including anti-inflammatory, anti-tumor, antioxidant. Studies have demonstrated gut microbiota metabolites are critical in developing rheumatoid arthritis (RA). In this study, we constructed collagen-induced (CIA) model rats. We used combined with treat CIA To observe effect on joint inflammation, rat feces were collected for 16 rRNA amplicon sequencing untargeted metabolomics analysis. The results showed index score swelling rats treated combination significantly than those alone groups. ameliorated disturbed regulation Candidatus_Saccharibacteria Clostridium_XlVb may be most critical. enhanced therapeutic compared -alone group. Furthermore, significant changes observed group, these differentially altered act as messengers host-microbiota interactions. These differential enriched into relevant metabolic pathways, revealing possible pathways

Language: Английский

Citations

5
Ginsenoside Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in non-small cell lung cancer DOI Creative Commons
Xiyu Liu, Jingjing Li, Qingqing Huang

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: April 26, 2024

Ginsenoside Rh2 (G-Rh2), a steroidal compound extracted from roots of ginseng, has been extensively studied in tumor therapy. However, its specific regulatory mechanism non-small cell lung cancer (NSCLC) is not well understood. Pyruvate dehydrogenase kinase 4 (PDK4), central regulator cellular energy metabolism, highly expressed various malignant tumors. We investigated the impact G-Rh2 on progression NSCLC and how it regulated PDK4 to influence aerobic glycolysis mitochondrial function.

Language: Английский

Citations

5
Ginsenoside-Rh2 Promotes Functional Recovery after Spinal Cord Injury by Enhancing TFEB-Mediated Autophagy DOI

Rongjie Liu,

Liting Jiang,

Yituo Chen

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(26), P. 14727 - 14746

Published: June 22, 2024

: Following spinal cord injury (SCI), autophagy plays a positive role in neuronal protection, whereas pyroptosis triggers an inflammatory response. Ginsenoside-Rh2 (GRh2), known for its neuroprotective effects, is considered promising drug. However, the exact molecular mechanisms underlying these protective effects remain unclear.

Language: Английский

Citations

4
PARP14 inhibits microglial activation via NNT to alleviate depressive-like behaviors in mice DOI
Xiaoyu Yu, Tingting Yang, Di Wu

et al.

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: 126, P. 235 - 246

Published: Feb. 18, 2025

Language: Английский

Citations

0
Ginsenoside Rh2 Ameliorates Myocardial Infarction by Regulating Cardiomyocyte Pyroptosis Based on Network Pharmacology, Molecular Docking, and Experimental Verification DOI
Bing Li, Shuanglong Mou, Chenrui Zhang

et al.

The American Journal of Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: March 18, 2025

Myocardial infarction (MI) is a significant threat to human health worldwide. Following MI, cardiomyocytes (CMs) undergo pyroptosis, exacerbating the damage caused by infarction. Ginseng may play role in alleviating CM pyroptosis. However, further exploration needed regarding its main active ingredients and effects. By employing network pharmacology on of ginseng, MI molecular docking between such pyroptosis-related proteins, we screened for ingredient ginseng. Through docking, identified ginsenoside Rh2, which acts cell as most likely that stably binds proteins. We subsequently constructed neonatal rat oxygen–glucose deprivation (OGD) model vitro an mouse vivo. Ginsenoside Rh2 was administered, with losartan used positive control. In OGD model, increased viability primary CMs mitigated OGD-induced vivo reduced decreased infarct size, improved cardiac function. Our study provides novel therapeutic strategy attenuating

Language: Английский

Citations

0
Ginsenoside Rh2 Alleviates Inflammatory Response and Enhances Motor Function Recovery in Spinal Cord Injury Mice via the ROS/MAPK14 Signaling Pathway DOI Creative Commons

Yanlan Wu,

Fangming Song,

Xiuwei Tan

et al.

Journal of Ginseng Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Ginsenoside Rh2 regulates cardiomyocyte autophagy-dependent apoptosis through the PI3K-Akt-mTOR signaling pathway to attenuate doxorubicin-induced cardiotoxicity DOI Creative Commons
Youping Wu, Sheng Zhang, Liqiang Gu

et al.

Applied Biological Chemistry, Journal Year: 2025, Volume and Issue: 68(1)

Published: April 7, 2025

Language: Английский

Citations

0
Research Progress of Genomics Applications in Secondary Metabolites of Medicinal Plants: A Case Study in Safflower DOI Open Access
Zhihua Wu,

Yan Na Hu,

Rui Hao

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3867 - 3867

Published: April 19, 2025

Medicinal plants, recognized as significant natural resources, have gained prominence in response to the increasing global demand for herbal medicines, necessitating large-scale production of these plants and their derivatives. are exposed a variety internal external factors that interact influence biosynthesis accumulation secondary metabolites. With rapid development omics technologies such genomics, transcriptomics, proteomics, metabolomics, multi-omics become important tools revealing complexity functionality organisms. They conducive further uncovering biological activities metabolites medicinal clarifying molecular mechanisms underlying Also, artificial intelligence (AI) technology accelerates comprehensive utilization high-dimensional datasets offers transformative potential analysis. However, there is currently no systematic review summarizing genomic metabolite plants. Safflower (Carthamus tinctorius L.) has rich diverse bioactive flavonoids, among which Hydroxysafflor yellow A (HSYA) specific safflower emerging medication treating wide range diseases. Hence, progress been made study an excellent example regulation recent years. Here, we on understanding main at level, summarize various types contents, with particular focus flavonoids. This aims provide insight into regulatory from perspective genomics.

Language: Английский

Citations

0
Liposome-Based Codelivery of AgFe2O4/TiO2 and Paclitaxel for Enhanced Breast Cancer Photothermal Chemotherapy DOI

Jia Liu,

Chenyu Huang,

Lingfeng Xie

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

Citations

0