Shikonin Inhibits Oral Cancer Progression Through Suppression of Metastasis and Angiogenesis and Induction of Autophagy and Apoptosis DOI Open Access
Min Wu, Chen Chen,

Pauline Chou

et al.

Jundishapur Journal of Natural Pharmaceutical Products, Journal Year: 2024, Volume and Issue: 19(4)

Published: Dec. 1, 2024

Background: Shikonin, a compound extracted from Lithospermum erythrorhizon, has demonstrated therapeutic effects on cancer; however, its oral cancer remain unclear. Objectives: This study aimed to explore the value of shikonin for treatment cancer. Methods: MTT, colony formation, and Transwell assays were employed evaluate inhibitory proliferation migration abilities human cell lines (SCC-4 SAS). Apoptosis viability assessed using TdT-mediated deoxyuridine triphosphate-biotin nick end-labeling (TUNEL) assay. To investigate potential anticancer mechanisms shikonin, RNA sequencing, quantitative PCR, western blotting performed analyze changes in expression levels cell-related genes proteins (matrix metalloproteinases-2 (MMP-2), matrix metalloproteinases-9 (MMP-9), VEGF-A, VEGF-C, Beclin-1, autophagy-related (ATG5), light chain-3 (LC-3)). Additionally, animal xenograft experiments conducted examine vivo antitumor shikonin. Results: The findings revealed that external application specifically targeted cells without affecting normal led dose-dependent inhibition their growth. Even at non-lethal doses, effectively suppressed production metalloproteinases, thereby inhibiting wound healing. Furthermore, reduced tumor progression factors, such as vascular endothelial growth factor (VEGF)-A which are released during early stages angiogenesis lymphangiogenesis. Meanwhile, higher doses induced autophagy activated ATG-5, LC-3B, Beclin-1. At lethal further decreased mitochondrial membrane potential, calcium ions, triggered apoptotic pathways. However, administration ion chelator (BAPTA-AM) inhibited shikonin-induced apoptosis. Conclusions: These results demonstrate induces activates pathways cells. Shikonin significantly apoptosis rat model. In conclusion, growth, metastasis, progression-related proteins. Given ease drug delivery affected area cancer, holds substantial future applications may improve patient recovery enhance cure rates.

Language: Английский

Complex roles of autophagy in cancer development, immune evasion, and drug resistance DOI

Xuegang Niu,

Qi Sheng You, Kejun Hou

et al.

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 78, P. 101170 - 101170

Published: Nov. 15, 2024

Language: Английский

Citations

24
Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties DOI Creative Commons
Eduardo Angulo-Elizari, Andreina Henriquez-Figuereo, Cristina Morán-Serradilla

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 268, P. 116249 - 116249

Published: Feb. 23, 2024

Cancer encompasses a group of pathologies with common characteristics, high incidence, and prevalence in all countries. Although there are treatments available for this disease, they not always effective or safe, often failing to achieve the desired results. This is why it necessary continue search new therapies. One strategies obtaining antitumor drugs use 1,4-naphthoquinone as scaffold synthetic natural products activity. review focuses on compiling studies related activity its derivatives over last 10 years. The work describes main naphthoquinones classifies based structural modifications made scaffold. Additionally, formation metal complexes using ligand considered. After thorough review, 197 compounds potent biological against cancer have been classified according their chemical structures mechanisms action described.

Language: Английский

Citations

13
Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer DOI Creative Commons
Xin Jin,

Wenke Jin,

L. Tong

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(7), P. 2815 - 2853

Published: April 24, 2024

Regulated cell death (RCD) is a controlled form of orchestrated by one or more cascading signaling pathways, making it amenable to pharmacological intervention. RCD subroutines can be categorized as apoptotic non-apoptotic and play essential roles in maintaining homeostasis, facilitating development, modulating immunity. Accumulating evidence has recently revealed that evasion frequently the primary cause tumor survival. Several have garnered attention promising cancer therapies due their ability induce regression prevent relapse, comparable apoptosis. Moreover, they offer potential solutions for overcoming acquired resistance tumors toward drugs. With an increasing understanding underlying mechanisms governing these subroutines, growing number small-molecule compounds targeting single multiple pathways been discovered, providing novel strategies current therapy. In this review, we comprehensively summarized regulatory emerging mainly including autophagy-dependent death, ferroptosis, cuproptosis, disulfidptosis, necroptosis, pyroptosis, alkaliptosis, oxeiptosis, parthanatos, mitochondrial permeability transition (MPT)-driven necrosis, entotic NETotic lysosome-dependent immunogenic (ICD). Furthermore, focused on discussing related compounds. brief, insightful findings may provide valuable guidance investigating individual collaborative approaches towards different ultimately driving discovery target significantly enhance future therapeutics.

Language: Английский

Citations

12
Natural products and derivatives in renal, urothelial and testicular cancers: Targeting signaling pathways and therapeutic potential DOI
Dengxiong Li, Jie Wang,

Zhouting Tuo

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 127, P. 155503 - 155503

Published: Feb. 28, 2024

Language: Английский

Citations

11
Exploiting Nanotechnology for Drug Delivery: Advancing the Anti-Cancer Effects of Autophagy-Modulating Compounds in Traditional Chinese Medicine DOI Creative Commons
Zixian Liu, Tianming Lu,

Ruoning Qian

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2507 - 2528

Published: March 1, 2024

Background: Cancer continues to be a prominent issue in the field of medicine, as demonstrated by recent studies emphasizing significant role autophagy development cancer. Traditional Chinese Medicine (TCM) provides variety anti-tumor agents capable regulating autophagy. However, clinical application autophagy-modulating compounds derived from TCM is impeded their restricted water solubility and bioavailability. To overcome this challenge, utilization nanotechnology has been suggested potential solution. Nonetheless, current body literature on nanoparticles delivering TCM-derived for cancer treatment limited, lacking comprehensive summaries detailed descriptions. Methods: Up November 2023, research study was conducted gather relevant data using databases, including PubMed, ScienceDirect, Springer Link, Web Science, CNKI. The keywords utilized investigation included "autophagy", "nanoparticles", "traditional medicine" "anticancer". Results: This review analysis overcoming delivery challenges enhancing anti-cancer properties TCM. evaluation based synthesis different classes TCM, mechanisms action treatment, benefits reported various scholarly sources. findings indicate that shows availability thereby opening up plethora therapeutic avenues. Conclusion: Nanotechnology enhance efficacy traditional through regulation Keywords: autophagy, nano-delivery, anti-cancer, medicine

Language: Английский

Citations

7
Autophagy flux in bladder cancer: Cell death crosstalk, drug and nanotherapeutics DOI
Kuan Liu, Huijing Chen, Yanhong Li

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 591, P. 216867 - 216867

Published: April 7, 2024

Language: Английский

Citations

6
Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo DOI
Ping Chen,

Xueer Zhang,

Qiaomiao Fang

et al.

Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 78(3), P. 677 - 692

Published: Feb. 25, 2024

Language: Английский

Citations

5
Phytochemical‐mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach DOI Creative Commons

Mazoun Al Azzani,

Zohra Nausheen Nizami, Rym Magramane

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(9), P. 4353 - 4385

Published: July 3, 2024

Autophagy and endoplasmic reticulum (ER) stress are conserved processes that generally promote survival, but can induce cell death when physiological thresholds crossed. The pro-survival aspects of these exploited by cancer cells for tumor development progression. Therefore, anticancer drugs targeting autophagy or ER to and/or block the being investigated extensively. Consistently, several phytochemicals have been reported exert their effects modulating stress. Various (e.g., celastrol, curcumin, emodin, resveratrol, among others) activate unfolded protein response stress-mediated apoptosis through different pathways. Similarly, various mechanisms (namely mechanistic target Rapamycin [mTOR] inhibition). However, phytochemical-induced function either as a cytoprotective mechanism programmed type II. Interestingly, at times, same phytochemical 6-gingerol, shikonin, II depending on cellular contexts, such type. Although there is well-documented interplay between stress, only one-way modulation was noted with some (carnosol, capsaicin, cryptotanshinone, guangsangon E, kaempferol, δ-tocotrienol): stress-dependent autophagy. Plant extracts sources potent while numerous in preclinical clinical studies, search novel ongoing from plant used traditional medicine Origanum majorana). Nonetheless, translation phytochemicals, promising avenue therapeutics, hindered limitations need be addressed future studies.

Language: Английский

Citations

3
Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy DOI Creative Commons

Fengzhao Liu,

Zhenyu Yang, Jixin Li

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Dec. 20, 2024

Abstract Diabetic kidney disease (DKD), one of the most prevalent microvascular complications diabetes, arises from dysregulated glucose and lipid metabolism induced by hyperglycemia, resulting in deterioration renal cells such as podocytes tubular epithelial cells. Programmed cell death (PCD), comprising apoptosis, autophagy, ferroptosis, pyroptosis, necroptosis, represents a spectrum demise processes intricately governed genetic mechanisms vivo. Under physiological conditions, PCD facilitates turnover cellular populations serves protective mechanism to eliminate impaired or cells, thereby preserving tissue homeostasis amidst hyperglycemic stress. However, existing research predominantly elucidates individual modes death, neglecting intricate interplay mutual modulation observed among various forms PCD. In this comprehensive review, we delineate diverse regulatory governing elucidate crosstalk dynamics distinct pathways. Furthermore, review recent advancements understanding pathogenesis explore their implications DKD. Additionally, potential natural products derived primarily botanical sources therapeutic agents, highlighting multifaceted effects on modulating crosstalk, proposing novel strategies for DKD treatment.

Language: Английский

Citations

3
Concise preparation of daldiquinone via palladium-catalyzed regioselective peri-C-H oxygenation of the naphthalene ring DOI Creative Commons
Jing Jiang,

Yue Gao,

Chenqi Wu

et al.

Journal of Chemical Research, Journal Year: 2025, Volume and Issue: 49(1)

Published: Jan. 1, 2025

A total synthesis of the natural polycyclic phenolic compound daldiquinone was reported derived from 1-naphthaldehyde. The utilizes regioselective peri-C-H oxidation as a key step, proceeding through longest linear sequence seven steps with an overall yield 40%. binaphthol intermediate is obtained via Baeyer-Villiger oxidative rearrangement in 81% yield, followed by IBX to produce naphthoquinone. binaphthalene core constructed using Suzuki coupling. This strategy, which relied on direct C-H bond naphthalene ring, significantly truncated synthetic pathway and boosted efficiency. regiospecific approach offers promising for obtaining wide array derivatives.

Language: Английский

Citations

0