Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 20, 2024
Language: Английский
Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 259, P. 108657 - 108657
Published: May 10, 2024
Language: Английский
Citations
14
Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(3), P. 105603 - 105603
Published: Jan. 4, 2024
The synthesis or derivation of a series structural analogues based on natural products is common strategy for discovering antitumor drugs. As unique diterpene derived from Trigonostemon howii, 3,4-seco-sonderianol (1) exhibited moderate cytotoxic effects. To improve the activity, new derivative (1b) with mitochondrial targeting function was synthesized by coupling triphenylphosphine to compound 1. Compared parent molecule, activity 1b increased greatly. A mechanistic experiments revealed that induced cancer cell apoptosis and inhibited migration mitochondria regulating STAT3 FAK signaling pathways. Meanwhile, found inhibit angiogenesis in transgenic zebrafish model. It worth noting also demonstrated excellent effects tumor xenotransplantation models. All evidence supports has potential be candidate an drug.
Language: Английский
Citations
5
Foods, Journal Year: 2024, Volume and Issue: 13(5), P. 796 - 796
Published: March 4, 2024
The genus Rosa is globally popular with well-established applications since it has a high edible and medicinal value. However, relatively limited research been conducted on the composition quality of wild fruits. present study aimed to compare properties chemical components five fruits, roxburghii, sterilis, laevigata, davurica, sericea. UPLC-ESI-MS/MS approach identified key metabolites among fruits as flavonoids, phenolic acids, organic acids. main differential are flavonoids (22.29–45.13%), acids (17–22.27%), terpenoids (7.7–24%), respectively. In total, 125 compounds served potential markers for species. Differential metabolic pathways were analyzed using KEGG approach. laevigata showed highest total polysaccharide (TPS) content 64.48 g/100 g. All extracts effectively decreased levels malondialdehyde while increasing activities superoxide dismutase glutathione peroxidase in H2O2-induced HaCaT cell model, demonstrating antioxidant development. Our findings suggest that studied exhibit biological activity value worth further exploration.
Language: Английский
Citations
5
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(20), P. 11503 - 11514
Published: April 18, 2024
The fruits of Rosa roxburghii Tratt. are edible nutritional food with high medicinal value and have been traditionally used as Chinese folk medicine for a long time. In this study, 26 triterpenoids including four new pentacyclic triterpenoids, roxbuterpenes A–D (1, 4, 5, 24), along 22 known analogues (2, 3, 6–23, 25, 26), were isolated from the R. roxburghii. Their chemical structures determined on basis extensive spectroscopic analyses (including IR, HRESIMS NMR spectroscopy). absolute configuration roxbuterpene A (1) was by an X-ray crystallographic analysis. This is first report crystal structure 5/6/6/6/6-fused system triterpenoid. Notably, B (1 4) possessed A-ring contracted triterpenoid nortriterpenoid skeletons rare system, respectively. Compounds 1–7, 11, 13–15, 18–20, 24, 25 exhibited moderate or potent inhibitory activities against α-glucosidase. 2, 6, 14 showed strong α-glucosidase IC50 values 8.4 ± 1.6, 7.3 2.2, 13.6 1.4, 0.9 0.4, 12.5 2.4 μM, respectively (positive control acarbose, 10.1 0.8 μM). 13, 14, 16 moderately inhibited release NO (nitric oxide) ranging 25.1 2.0 to 51.4 3.1 μM. Furthermore, expressions TNF-α (tumor necrosis factor-α) IL-6 (interleukin-6) detected ELISA (enzyme-linked immunosorbent assay), compounds effects in dose-dependent manner 50
Language: Английский
Citations
5
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114126 - 114126
Published: Jan. 24, 2025
Language: Английский
Citations
0
CytoJournal, Journal Year: 2025, Volume and Issue: 22, P. 20 - 20
Published: Feb. 14, 2025
Objective Chloride intracellular channel 6 (CLIC6) is essential for the development of cancer, and it widely studied treatment various cancers. This study aimed to explore potential mechanisms CLIC6 in hepatocellular carcinoma (HCC). Material Methods Initially, a subcutaneous xenograft model HCC was established. The groups were treated with varying levels recombinant protein. After 21 days, tumor liver tissues harvested. Tumor size weight measured, hematoxylin-eosin staining used assess histopathological changes tissues. Terminal deoxynucleotidyl transferase-mediated 2’-deoxyuridine 5’-triphosphate nick-end labeling employed evaluate apoptosis tissue cells. Quantitative real-time polymerase chain reaction Western blot utilized analyze cytokine messenger ribonucleic acid ( mRNA) or tissues, immunohistochemistry conducted expression. Results significantly inhibits proliferation enhances markedly reduces mRNA interleukin (IL)-6, IL-1β, interferon-γ, necrosis factor-α, IL-17A when increasing transforming growth factor-β IL-4 levels. potentially modulates Th cell balance by regulating forkhead box protein P3, GATA-binding 3, T-box expressed T cell, retinoic receptor-related orphan receptor γt (ROR-γt) expression, thereby restraining progression mice. Moreover, mitigates hepatic oxidative damage via Janus tyrosine kinase 1/signal transducer activator transcription pathway, attenuates c-Jun N-terminal (JNK) phosphorylation, apoptosis-related proteins, effectively hindering development. Conclusion demonstrates potent antitumor effects through inhibition proliferation, promotion apoptosis, modulation levels, regulation immune balance, attenuation stress pathways.
Language: Английский
Citations
0
Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: 498, P. 117296 - 117296
Published: March 13, 2025
Language: Английский
Citations
0
Foods, Journal Year: 2025, Volume and Issue: 14(8), P. 1301 - 1301
Published: April 9, 2025
Cili (Rosa roxburghii Tratt) fruit is a nutrient-rich edible plant known for its antioxidant and hepatoprotective properties. However, conventional extraction methods often lead to the degradation of bioactive compounds. In this study, we developed low-temperature homogenate-assisted high-pressure disruption (HHPD) method obtain phytochemically enriched cili extract (HHPD-CFE). The chemical characterization HHPD-CFE showed that it contained higher levels polyphenols, polysaccharides, superoxide dismutase (SOD) than those in squeeze extraction. effects were evaluated oxidative stress-induced liver injury hepatic fibrosis models. mitigated damage by reducing malondialdehyde while enhancing SOD glutathione activity. Additionally, inhibited activation stellate cells (HSC-T6) reduced collagen deposition, suggesting protective role against fibrosis. These findings support promising botanical with compounds liver-protective This study supports potential application optimized techniques preserve thermosensitive improve efficacy functional foods health.
Language: Английский
Citations
0
Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106860 - 106860
Published: April 29, 2025
Language: Английский
Citations
0
Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1575 - 1575
Published: April 1, 2024
Objective: This study aimed to investigate methodologies for the extraction and purification of polysaccharides from Rosa roxburghii Tratt fruits their impact on various cellular processes in prostate cancer DU145 cells, including survival rate, migration, invasion, cell cycle, apoptosis. Results: Compared control group, polysaccharide exhibited a significant reduction viability, invasion rates cells time- dose-dependent manner within polysaccharide-treated groups. Additionally, it effectively arrested cycle at G0/G1 phase by downregulating expressions CDK-4, CDK-6, Cyclin D1. Furthermore, induced apoptosis upregulating Caspase 3, 8, 9, BAX. Methods: Polysaccharides were extracted sourced Yunnan, China. Extraction decolorization methods optimized using response surface methodology, based single-factor experiment. Polysaccharide was carried out DEAE-52 cellulose Sephadex G-100 column chromatography. The optimal dosage R. affecting determined CCK-8 assay. Cell migration assessed transwell scratch assays. Flow cytometry employed analyze effects Western blotting Quantitative real-time PCR utilized examine protein mRNA respectively. Conclusions: polysaccharides, consisting D-mannose, L-rhamnose, N-acetyl-D-glucosamine, D-galacturonic acid, D-glucose, D-galactcose, D-xylose, L-arabinose, L-fucose, possess ability hinder proliferation, while inducing through modulation relevant gene expressions.
Language: Английский
Citations
2