5,7-Dihydroxyflavone acts on eNOS to achieve hypotensive effects in spontaneously hypertensive rats

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Hypertension is one of the most serious chronic diseases. This study will focus on systemic antihypertensive mechanisms 5,7-dihydroxyflavone from in silico simulations to vivo validations. In-silico studies were applied by network pharmacology, molecular docking, and dynamic simulation. Based information could act several different blood pressure regulating pathways, docking results confirmed it might direct binding active pocket eNOS, average distance between -eNOS less than 0.4 Å The carried SHRs oral administrated with 10 mg/kg that alleviate hypertensive symptoms within 30 min, but if pretreated L-NAME (10 mg/kg, an eNOS inhibitor) can erase anti-hypertensive effects 5,7-dihydroxyflavone, no affected aminoguanidine pretreatment (100 selective antagonist iNOS). Furthermore, administration does not affect heart rate pulse difference SHR rats. In conclusion, regulation may as agonist achieve its acute effects. These suggest has potential be a candidate medication for urgently lowering requirements without posing risks.

Language: Английский

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Anti-Inflammatory Activities of Some Plants of Genus Alpinia: Insights from In Vitro, In Vivo, and Human Studies

Journal of Experimental Pharmacology, Journal Year: 2025, Volume and Issue: Volume 17, P. 51 - 91

Published: Jan. 1, 2025

This narrative review intends to provide thorough information on the anti-inflammatory activities of Alpinia plants, largest genus family Zingiberaceae. The articles were searched PubMed database using 'Alpinia AND activity' as keywords, filtered published from 2020 2024 and free full-text. Of approximately 248 members most commonly studied for their are A. galanga, officinarum, zerumbet, oxyphylla. Only zerumbet have been in humans. Studies animal models revealed that plants contributed exogenous antioxidants, reduced proinflammatory cytokines, inhibited enzymes, improved gastric acid gastrointestinal motility, promoted ulcer healing. terpenoids, flavonoids (such kaempferol, quercetin, galangin), diarylheptanoids obtained rhizomes these may crucially play important roles activities. These did not show toxicity toward numerous normal cell lines (RAW 264.7, IEC-6, HepG2, MT-4, NIH-3T3, Vero cells, human peripheral blood mononuclear HaCaT) but toxic cancer (HT29). In humans, galanga was its effects psychostimulants improving mental health, sperm erectile dysfunction. Similarly, officinarum could improve morphology idiopathic infertility, whereas worked a cardio-myorelaxant patients with cardiovascular diseases.

Language: Английский

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Integrated analysis of transcriptome and metabolome reveals the molecular basis of quality differences in Alpinia oxyphylla Miq. from geo-authentic and non-authentic areas

Plant Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: 222, P. 109755 - 109755

Published: March 5, 2025

Language: Английский

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Chemopreventive Potential of Paddy Waste: A Promising Approach Against Benign Prostate Hyperplasia in Spontaneously Hypertensive Rats

Analytical Cellular Pathology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Benign prostate hyperplasia (BPH) is common in elderly men. Previously, paddy waste (both husk and straw) reportedly had chemopreventive potential. The main aim of this study was to explore the properties against disease. This determines antiproliferative activity product spontaneously hypertensive rats (SHRs). Methods: Aqueous methanol extracts straw were administered SHRs for 17 weeks via drinking water, with no observed toxicity on dietary intake, body weight, liver, or kidney. used 18 male model primary hypertension 6 Wistar Kyoto (WKY) as normotensive controls. divided into three groups: control (n = 6), treated 6, 15 mg/kg), treatment delivered water. Results: It managed reduce blood pressure (72.0 mmHg; p < 0.01) size ventral around 0.05% (p 0.01). Histological analysis revealed signs such a reduction number acini (7.50; 0.01), epithelial height (10.55 µm; acinar area (18.17%; have arrested cell cycle by downregulating proliferative marker, Ki-67, proliferating nuclear antigen (PCNA). Prostate growth downregulation androgen receptor (AR) which inhibited AR mRNA transcription (RTPCR analysis) induced arrest at S phase through p27 cyclin E2 (western blot analysis). Conclusion: In conclusion, especially better agent

Language: Английский

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Research progress in the extraction and purification, structural characteristics, pharmacological activities, structure-activity relationships, and applications from Alpinia oxyphylla Miq. polysaccharides

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144387 - 144387

Published: May 1, 2025

Language: Английский

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Integrating network pharmacology and multi-omics to explore the mechanism of Callicarpa kwangtungensis Chun in ameliorating Alzheimer's disease pathology in APP/PS1 mice

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119148 - 119148

Published: Nov. 1, 2024

Language: Английский

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The potential uses of Galangal (<i>Alpinia</i> sp.) essential oils as the sources of biologically active compounds

AIMS Agriculture and Food, Journal Year: 2024, Volume and Issue: 9(4), P. 1064 - 1109

Published: Jan. 1, 2024

<p>The uses of essential oils in food and traditional medicine have attracted researchers worldwide for applications the food, agriculture, cosmetics, health industries. Among sources oils, Alpinia genus produces galangal with great potential use many applications. This has been used a long time some countries along flavouring spices. These from plant organs this contain several bioactive compounds typical phytochemical is 1,8-cineole or eucalyptol. Scientifically, bioactivity proven. Some efforts conducted efficiently to extract oil, including using novel technologies-This article aims review species bearing their uses, phytochemicals bioactivity, methods extraction, profiles, stabilization, these oils. also compares The results show that history as medicines countries. There closely correlation between scientifically proven benefits. studies on oil deeply explored capability antioxidants, antimicrobial, anti-inflammatory, anticancer, anti-antiparasitic activities cardiovascular impairment. are correlated bioactivity. Galangal characterized by presence 1,8-cineole. found parts organ its concentration varies depending species. indicates technologies produce higher yield than conventional method extraction. application constraint high hydrophobicity, resulting poor solubility aqueous phase. Various techniques emulsification improve water miscibility. sectors such pharmaceutical personal care appropriate extraction still challenge mainly preserving compounds. Another exploring other <italic>Alpinia</italic> species, proof benefits, sectors.</p>

Language: Английский

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Recent Research Progress on the Chemical Constituents, Pharmacology, and Pharmacokinetics of Alpinae oxyphyllae Fructus

Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3905 - 3905

Published: Aug. 18, 2024

fructus (AOF), the dried mature fruit of

Language: Английский

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Mechanism of action of Xipayimaizibizi oral liquid on outlet obstruction-induced overactive bladder: An integrated study

Journal of Traditional Chinese Medical Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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