Exploring the Underlying Mechanisms of Preventive Treatment Related to Dietary Factors for Gastric Diseases DOI

Kaina Qiao,

Zichong Song,

Liang Li

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(32), P. 17782 - 17801

Published: Aug. 5, 2024

Gastric diseases have emerged as one of the main chronic in humans, leading to considerable health, social, and economic burdens. As a result, using food or "food medicinal homologous substances" has become an effective strategy prevent gastric diseases. Diet may play crucial role prevention mitigation diseases, particularly long-term regular intake specific dietary components that protective effect on stomach. These key components, extracted from food, include polysaccharides, alkaloids, terpenoids, polyphenols, peptides, probiotics, etc. The related mechanisms involve regulating acid secretion, protecting mucosa, increasing release defense factors, decreasing level inflammatory inhibiting

Language: Английский

Crosstalk between bile acids and gut microbiota: a potential target for precancerous lesions of gastric cancer DOI Creative Commons

Maofu Zhang,

Jialin Zhong, Yanyun Shen

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 13, 2025

As a critical juncture in the pathological continuum from gastritis to gastric cancer, precancerous lesions of cancer (PLGC) are increasingly prevalent, significantly undermining health global population. The primary constituents bile, specifically bile acids (BAs), disrupt equilibrium hormone secretion and compromise structural integrity mucosa, thereby facilitating oncogenesis. Moreover, gut microbiota modulate host physiological processes through immune response regulation, metabolic pathway interference, direct interaction with tumor cells. Extensive research has elucidated that dysregulation BAs microbiota, concert resultant impairment central pathogenesis PLGC. In anticipation future clinical preventive therapeutic strategies, this review collates recent insights into roles bacteria PLGC, examining their interplay significance pathogenic mechanism

Language: Английский

Citations

0
Streptococcus anginosus in the development and treatment of precancerous lesions of gastric cancer DOI Open Access

Su-Ting Qian,

Hao-Yu Zhao,

Feifei Xie

et al.

World Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 16(9), P. 3771 - 3780

Published: Sept. 9, 2024

The microbiota is strongly association with cancer. Studies have shown significant differences in the gastric between patients cancer (GC) and noncancer patients, suggesting that may play a role development of GC. Although Helicobacter pylori (H. ) infection widely recognized as primary risk factor for GC, recent studies based on sequencing technology revealed non-H. microbes also impact A study discovered Streptococcus anginosus (S. more prevalent mucosa GC than those without S. can spontaneously induce chronic gastritis, mural cell atrophy, mucoid chemotaxis, heterotrophic hyperplasia, which promote precancerous lesions (PLGC). disrupts barrier function, promotes proliferation cells, inhibits apoptosis. However, underrepresented literature. Recent reports suggest it cause lesions, indicating its emerging pathogenicity. Modern novel molecular diagnostic techniques, such polymerase chain reaction, genetic testing, Ultrasensitive Chromosomal Aneuploidy Detection, be used to via microbial markers. Therefore, we present concise summary relationship PLGC. Our aim was further investigate new methods preventing treating PLGC by exploring pathogenicity

Language: Английский

Citations

3
Oxidative Stress and Redox Signaling in Gastric Cancer: From Mechanisms to Therapeutic Implications DOI Creative Commons
Zehua Chen,

Jiawu Fan,

Xiao‐Long Chen

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 258 - 258

Published: Feb. 24, 2025

Oxidative stress, which is characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, has critical roles in the initiation, progression, treatment of gastric cancer. On one hand, excessive ROS accumulation induces oxidative damage cancer cell death. other moderate levels cause genetic mutations dysregulation signaling pathways to promote proliferation, inflammation, angiogenesis, metastasis Notably, emerging evidence revealed that also mediate post-translational modifications (oxPTMs) redox-sensitive proteins, can directly affect protein functions regulate redox cells. Therefore, elucidating regulatory mechanisms stress holds great promise identify novel therapeutic targets or redox-targeting strategies. This review will summarize regulating hallmarks highlight ROS-mediated oxPTMs In addition, we discuss strategies targeting for cancer, with emphasis on use bioactive natural products nanomaterials.

Language: Английский

Citations

0
MiR-3613-5p targets AQP4 to promote the progression of chronic atrophic gastritis to gastric cancer DOI Creative Commons

Jian Bi,

Yu‐Fen Wang, Ying-De Wang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 4, 2025

Introduction: Gastric cancer (GC) exhibits high invasiveness, delayed diagnosis, and poor prognosis. Chronic atrophic gastritis (CAG), an initial stage within the Correa cascade, induces gastric mucosal inflammation atrophy, promoting genetic epigenetic alterations. MicroRNAs (miRNAs) dysregulation has been implicated in tumorigenesis, yet their specific roles CAG progression to GC remain unclear. Methods: Using clinical data from GEO database, we identified miRNAs differentially expressed mucosa serum samples patients. Murine models were established through administration of N-methyl-N-nitrosourea (MNU) high-salt diet (HSD). In vitro functional assays evaluated proliferation migration after miRNA modulation cell lines. MiRNA target validation involved luciferase reporter assays. Results: MiR-3613-5p expression was significantly elevated patients, tissues tumor tissues, human demonstrated increased miR-3613-5p following MNU HSD-induced CAG. Functionally, overexpression promoted vitro, whereas silencing alleviated pathological alterations (atrophy, hyperplasia, inflammatory infiltration) vivo. Mechanistically, inhibited Aquaporin 4 (AQP4) by directly targeting its 3'UTR. Discussion: Our findings provide first evidence that facilitates toward via negative regulation AQP4. These results highlight as a promising biomarker therapeutic target, suggesting antagomiR-3613-5p potential novel strategy prevent carcinogenesis.

Language: Английский

Citations

0
Diosmin-Hesperidin Fixed-Dose Combination Ameliorates Cisplatin-Induced Hepotorenal Toxicities in Wistar Rats: Involvements of Antioxidant and Anti-Inflammatory Mechanisms DOI
Adejuwon Adewale Adeneye,

Favor O. Ogunole,

Quadri Remi-Lawal

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Microbiota–gut–brain axis: Natural antidepressants molecular mechanism DOI

Yitong Lu,

Xiaowen Yu, Zhongling Wang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 134, P. 156012 - 156012

Published: Aug. 31, 2024

Language: Английский

Citations

2
Modified Zuojin pill alleviates gastric precancerous lesions by inhibiting glycolysis through the HIF-1α pathway DOI
Shan Liu,

Haijie Ji,

Tai Zhang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156255 - 156255

Published: Nov. 17, 2024

Language: Английский

Citations

1
Sqqt Decoction Alleviates Gastric Precancerous Lesions by Inhibiting Glycolysis Through the Hif-1α Pathway DOI
Shan Liu,

Haijie Ji,

Tai Zhang

et al.

Published: Jan. 1, 2024

BackgroundGastric precancerous lesions (GPL) typically originates from chronic gastritis (CG), and the changes in glycolysis regulated by HIF-1α pathway progression of CG to GPL are unclear. SQQT decoction is a traditional Chinese herbal formula used for treating GPL. However, underlying mechanism has not been fully elucidated.PurposeTo investigate whether can alleviate inhibiting through pathway.MethodsA rat model was established, were detected 12th, 18th, 24th, 30th weeks. The therapeutic efficacy evaluated pathological changes. In vitro, cell (MC cell) originated GES-1 cells intervened MNNG. effects on vivo vitro. overexpression confirmed that inhibited targeting pathway.ResultsOur study revealed exhibited dynamic GPL, characterized sequential activation, deactivation, reactivation. treatment ameliorated gastric mucosal dysplasia. Mechanistic studies influenced pathway, improved abnormal cellular proliferation apoptosis. Importantly, blocked effect glycolysis.ConclusionIn pathway-regulated reduced apoptosis mucosa, thereby exerting

Language: Английский

Citations

0
Exploring the Underlying Mechanisms of Preventive Treatment Related to Dietary Factors for Gastric Diseases DOI

Kaina Qiao,

Zichong Song,

Liang Li

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(32), P. 17782 - 17801

Published: Aug. 5, 2024

Gastric diseases have emerged as one of the main chronic in humans, leading to considerable health, social, and economic burdens. As a result, using food or "food medicinal homologous substances" has become an effective strategy prevent gastric diseases. Diet may play crucial role prevention mitigation diseases, particularly long-term regular intake specific dietary components that protective effect on stomach. These key components, extracted from food, include polysaccharides, alkaloids, terpenoids, polyphenols, peptides, probiotics, etc. The related mechanisms involve regulating acid secretion, protecting mucosa, increasing release defense factors, decreasing level inflammatory inhibiting

Language: Английский

Citations

0