Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Nov. 1, 2024
The
role
of
interleukin-18
(IL-18)
and
inflammasomes
in
chronic
inflammatory
airway
diseases,
such
as
asthma
obstructive
pulmonary
disease
(COPD),
has
garnered
significant
attention
recent
years.
This
review
aims
to
provide
an
overview
the
current
understanding
IL-18
biology,
associated
signaling
pathways,
involvement
inflammasome
complexes
diseases.
We
explore
multifaceted
pathophysiology,
including
its
interactions
with
other
cytokines
contributions
both
T2
non-T2
inflammation.
Importantly,
emerging
evidence
highlights
a
critical
player
severe
asthma,
contributing
inflammation,
hyperresponsiveness
(AHR),
mucus
impaction.
Furthermore,
we
discuss
IL-18's
autoimmunity
highlight
potential
therapeutic
targets
within
pathways
patients
infections
autoimmune
responses.
By
synthesizing
advancements
ongoing
research,
this
underscores
importance
novel
target
treatment
related
conditions.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 26, 2024
Allergic
diseases
like
asthma,
allergic
rhinitis
and
dermatitis
pose
a
significant
global
health
burden,
driving
the
search
for
novel
therapies.
The
NLRP3
inflammasome,
key
component
of
innate
immune
system,
is
implicated
in
various
inflammatory
diseases.
Upon
exposure
to
allergens,
undergoes
two-step
activation
process
(priming
assembly)
form
active
inflammasomes.
These
inflammasomes
trigger
caspase-1
activation,
leading
cleavage
pro-inflammatory
cytokines
(IL-1β
IL-18)
GSDMD.
This
induces
pyroptosis
amplifies
inflammation.
Recent
studies
humans
mice
strongly
suggest
link
between
IL-1β,
IL-18,
development
However,
further
research
needed
fully
understand
NLRP3's
specific
mechanisms
allergies.
review
aims
summarize
latest
advances
regulation.
We
will
discuss
small
molecule
drugs
natural
products
targeting
as
potential
therapeutic
strategies
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 22, 2024
Chelidonium
majus
L.
(
C.
majus)
,
commonly
known
as
“Bai
Qu
Cai”
in
China,
belongs
to
the
genus
of
Papaveraceae
family.
It
has
rich
medicinal
value,
such
alleviating
coughs,
asthma,
spasms
and
pain.
Recent
studies
have
demonstrated
that
is
abundant
various
alkaloids,
which
are
primary
components
a
range
pharmacological
effects,
including
anti-microbial,
anti-inflammatory,
anti-viral,
anti-tumor
effects.
So
far,
94
alkaloids
been
isolated
from
benzophenanthridine,
protoberberine,
aporphine,
protopine
other
types
alkaloids.
This
paper
aims
review
research
progress
phytochemistry,
pharmacology
toxicology
order
provide
theoretical
basis
for
application
field
chemistry
afford
reference
further
development
efforts.
Frontiers in Bioscience-Landmark,
Journal Year:
2025,
Volume and Issue:
30(2)
Published: Feb. 19, 2025
Pediatric
asthma
is
a
common
respiratory
condition
in
children,
characterized
by
complex
interplay
of
environmental
and
genetic
factors.
Evidence
shows
that
the
airways
stimulated
asthmatic
patients
have
increased
oxidative
stress,
but
exact
mechanisms
through
which
this
stress
contributes
to
progression
are
not
fully
understood.
Oxidative
originates
from
inflammatory
cells
airways,
producing
significant
amounts
reactive
oxygen
species
(ROS)
nitrogen
(RNS).
External
factors
such
as
cigarette
smoke,
particulate
matter,
atmospheric
pollutants
also
contribute
ROS
RNS
levels.
The
accumulation
these
disrupts
cellular
redox
balance,
leading
heightened
activates
signaling
pathways
modulates
release
factors,
worsening
inflammation.
Therefore,
understanding
sources
impacts
pediatric
crucial
developing
antioxidant-based
treatments.
This
review
examines
children
with
asthma,
role
development,
potential
antioxidants
therapeutic
strategy
for
asthma.
Frontiers in Veterinary Science,
Journal Year:
2025,
Volume and Issue:
12
Published: March 12, 2025
Introduction
Infectious
bronchitis
(IB)
poses
a
major
challenge
to
global
poultry
production,
causing
substantial
economic
burdens
and
underscoring
the
necessity
for
novel
therapeutic
interventions
given
limitations
of
current
vaccines
conventional
antiviral
agents.
The
purpose
this
study
is
comprehensively
explore
active
components
in
Shuanghuanglian
their
interaction
with
key
pathological
targets
IBV
(Infectious
virus)
infection.
By
using
advanced
computational
methods,
aims
not
only
identify
potential
ingredients,
but
also
reveal
mechanism
action
against
IBV.
Methods
Through
integrative
systems
pharmacology
approaches,
we
systematically
investigated
its
phytochemical
constituents
IB,
employing
multi-omics
analysis,
ensemble
machine
learning,
all-atom
molecular
dynamics
(MD)
simulations.
Network
revealed
65
target
genes
associated
Shuanghuanglian’s
primary
bioactive
(quercetin,
kaempferol,
wogonin,
luteolin),
exhibiting
high
network
centrality.
Results
Using
TCMSP
database,
found
components,
such
as
quercetin
which
exhibited
strong
connectivity
our
analysis.
GeneCards
database
identified
40
common
shared
by
IB.
Importantly,
BCL2
IL6
were
recognized
protein–protein
(PPI)
highlighting
roles
apoptosis
inflammation.
Furthermore,
analyses
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathways
significant
regulating
cell
cycle
inflammatory
responses.
Machine
learning
techniques
critical
intervention,
supported
docking
results
that
showed
binding
energies.
simulations
confirm
stability
complexes,
importance
these
interactions
treatment
efficacy.
Conclusion
We
used
variety
analytical
finally
ingredients
quercetin,
luteolin.
play
role
avian
infectious
inhibiting
reducing
response.
