Epigenetic Effects of Natural Products in Inflammatory Diseases: Recent Findings DOI Open Access
Qi Yao, Wei Tian, Hongmei Qiu

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Inflammation is an essential step for the etiology of multiple diseases. Clinically, due to limitations current drugs treatment inflammatory diseases, such as serious side effects and expensive costs, it urgent explore novel mechanisms medicines. Natural products have received extensive attention recently because their multi-component multi-target characteristics. Epigenetic modifications are crucial pathophysiological targets developing innovative therapies pharmacological interventions. Investigations examining how natural improving inflammation through epigenetic emerging. This review state that relieve via regulating gene transcription levels chromosome structure regulated by histone acetylation addition or deletion methyl groups on DNA duplex. They could also exert anti-inflammatory modulating proteins in typical signaling pathways ubiquitin-related degradation effect glycolysis derived free glycosyls. Studies potential facilitate development therapeutic agents. Future research directed at better understanding modulate processes less studied including neddylation, SUMOylation, palmitoylation lactylation, may provide new implications. Meanwhile, higher quality preclinical studies more powerful clinical evidence still needed firmly establish efficacy products. Trial Registration: ClinicalTrials.gov Identifier: NCT01764204; NCT05845931; NCT04657926; NCT02330276.

Language: Английский

Dihuang Yinzi Improves Scopolamine-Induced Learning and Memory Impairment by Regulating Plasma Exosome-Derived BDNF DOI

Wenna Su,

Yuzhong Du,

Wenting Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119322 - 119322

Published: Jan. 1, 2025

Language: Английский

Citations

0
Activation of Sirt6 by icariside Ⅱ alleviates depressive behaviors in mice with poststroke depression by modulating microbiota-gut-brain axis DOI Creative Commons
Jianmei Gao, Y.L. He, Feng Shi

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Sirt6-mediated gut microbiota plays a vital role in poststroke depression (PSD). Icariside Ⅱ (ICS Ⅱ) is naturally-occurring neuroprotectant with Sirt6 induction potency. However, it unknown whether ICS protects against PSD through modulation of microbiota. This study aimed to reveal the effect and potential mechanisms on PSD, microbiota-gut-brain axis was investigated. Using middle cerebral artery occlusion (MCAO) chronic unpredictable mild stress (CUMS) establish post-stroke (PSD) mice, we assessed anti-depressant effects via behavioral tests, immunohistochemistry, western blot. Transcriptome profiling, molecular docking, surface plasmon resonance were used identify key targets. 16S rDNA genomic-derived taxonomic profiling fecal transplantation (FMT) conducted figure out mechanistic short-chain fatty acids (SCFAs). ameliorated depressive-like behaviors mice as evidenced by sucrose preference test, forced swimming test tail suspension test. restored mitochondrial function, reduced oxidative damage pro-inflammatory cytokines both brain intestine regulation Sirt6/NF-κB pathway. significantly increased abundance (such asAkkermansia Ligilactobacillus), enhanced SCFAs concentrations, repaired intestinal barrier integrity upreglated tight junction protein expression. FMT from II-treated replicated these benefits, confirming microbiota's role. Mechanistically, directly bound its activity. Ⅱ-mediated neuroprotection neutralized or hydrogen peroxide-induced enteric glial cells when absent. Our findings expand pharmacological properties II demonstrating ability ameliorate axis. Ⅱ, novel activator, could be translated into an alternative microbiota-targeted avenue for coping PSD.

Language: Английский

Citations

0
Depressive Behavior and BDNF/TrkB Signaling DOI

Megha Jha,

Jajati K. Pasupalak,

Girdhari Lal Gupta

et al.

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Jan. 1, 2024

Language: Английский

Citations

1
Serum Levels and Clinical Significance of NSE, BDNF and CNTF in Patients with Cancer-associated Ischemic Stroke Complicated with Post-stroke Depression DOI Open Access

Baigui Zhou,

Kun Mu,

Xuzhou Yu

et al.

Actas Españolas de Psiquiatría, Journal Year: 2024, Volume and Issue: 52(4), P. 474 - 483

Published: Aug. 5, 2024

The incidence of post-stroke depression (PSD) may be higher in patients with cancer-associated ischemic stroke (CAIS). pathogenesis PSD is mainly related to the emotional injury and inability neurons effectively repair. This study aims explore clinical significance serum neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF) ciliary (CNTF) expression levels CAIS patients.

Language: Английский

Citations

0
The involvement of 5-HT was necessary for EA-mediated improvement of post-stroke depression DOI Creative Commons

Lulu Yao,

Bing Deng,

Wenhui Di

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract The prevalence of depression is as high about 30% within five years after stroke, while there still no breakthrough the Western medical treatments for post-stroke (PSD) in clinical practice. traditional acupuncture treatment practiced to be effective therapy PSD, but its mechanism needs elucidated. With a combination methods, including behavioral testing, in vivo electrophysiological recording, mRNA sequencing, immunofluorescence, fiber and genetic modulation, this study showed that electroacupuncture (EA) at Baihui (GV20) Shenting (GV24) acupoints improved depressive-like behaviors neuronal activities PSD model mice, which was established by bilateral injection collagenase IV into medial prefrontal cortex (mPFC). Moreover, it found EA-mediated improvement comparable fluoxetine. sequence analysis indicated 5-hydroxytryptamine (5-HT) system involved pathogenesis PSD. Meanwhile, number 5-HT positive neurons dorsal raphe nucleus (DRN) transmitter mPFC significantly decreased, ablation DRN could prevent efficacy EA. Together, our results have provided insight biological underlying revealed scientific connotation both value.

Language: Английский

Citations

0
Epigenetic Effects of Natural Products in Inflammatory Diseases: Recent Findings DOI Open Access
Qi Yao, Wei Tian, Hongmei Qiu

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Inflammation is an essential step for the etiology of multiple diseases. Clinically, due to limitations current drugs treatment inflammatory diseases, such as serious side effects and expensive costs, it urgent explore novel mechanisms medicines. Natural products have received extensive attention recently because their multi-component multi-target characteristics. Epigenetic modifications are crucial pathophysiological targets developing innovative therapies pharmacological interventions. Investigations examining how natural improving inflammation through epigenetic emerging. This review state that relieve via regulating gene transcription levels chromosome structure regulated by histone acetylation addition or deletion methyl groups on DNA duplex. They could also exert anti-inflammatory modulating proteins in typical signaling pathways ubiquitin-related degradation effect glycolysis derived free glycosyls. Studies potential facilitate development therapeutic agents. Future research directed at better understanding modulate processes less studied including neddylation, SUMOylation, palmitoylation lactylation, may provide new implications. Meanwhile, higher quality preclinical studies more powerful clinical evidence still needed firmly establish efficacy products. Trial Registration: ClinicalTrials.gov Identifier: NCT01764204; NCT05845931; NCT04657926; NCT02330276.

Language: Английский

Citations

0