miCGR: interpretable deep neural network for predicting both site-level and gene-level functional targets of microRNA DOI Creative Commons
Xiaolong Wu,

Lehan Zhang,

Xiaochu Tong

et al.

Briefings in Bioinformatics, Journal Year: 2024, Volume and Issue: 26(1)

Published: Nov. 22, 2024

Abstract MicroRNAs (miRNAs) are critical regulators in various biological processes to cleave or repress translation of messenger RNAs (mRNAs). Accurately predicting miRNA targets is essential for developing miRNA-based therapies diseases such as cancer and cardiovascular disease. Traditional target prediction methods often struggle due incomplete knowledge miRNA-target interactions lack interpretability. To address these limitations, we propose miCGR, an end-to-end deep learning framework functional targets. MiCGR employs 2D convolutional neural networks alongside enhanced Chaos Game Representation (CGR) both sequences their candidate site (CTS) on mRNA. This advanced CGR transforms genetic into informative graphical representations based sequence composition subsequence frequencies, explicitly incorporates important prior seed regions positions. Unlike one-dimensional solely characters, this approach identifies motifs within sequences, even if they distant the original sequences. Our model outperforms existing at gene levels. enhance interpretability, incorporate Shapley value analysis each sites, allowing miCGR achieve improved accuracy, particularly with more lenient CTS selection criteria. Finally, two case studies demonstrate practical applicability highlighting its potential provide insights optimizing artificial analogs that surpass endogenous counterparts.

Language: Английский

Advances in precision gene editing for liver fibrosis: From technology to therapeutic applications DOI Open Access
Peng Ji,

Yan Li,

Zihan Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117003 - 117003

Published: June 21, 2024

This review presents a comprehensive exploration of gene editing technologies and their potential applications in the treatment liver fibrosis, condition often leading to serious complications such as cancer. Through an in-depth current literature critical analysis, study delves into intricate signaling pathways underlying fibrosis development examines promising role alleviating this disease burden. Gene offer precise, efficient, reproducible tools for manipulating genetic material, holding significant promise basic research clinical practice. The manuscript highlights challenges risks associated with technology. By synthesizing existing knowledge exploring future perspectives, aims provide valuable insights precision combat its complications, ultimately contributing advances therapy.

Language: Английский

Citations

4
Salidroside attenuates NASH through regulating bile acid-FXR/TGR5 signaling pathway via targeting gut microbiota DOI
Jun Zhang, Jing Zhou,

Zheyun He

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142276 - 142276

Published: March 1, 2025

Language: Английский

Citations

0
Risk Signal Mining and Analysis of PCSK9 Inhibitors Based on FAERS Database DOI
Li Peng, Min Xie,

Bimin Feng

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Benzoxanthenone Lignans Related to Carpanone, Polemanone, and Sauchinone: Natural Origin, Chemical Syntheses, and Pharmacological Properties DOI Creative Commons
Christian Bailly

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1696 - 1696

Published: April 10, 2025

Medicinal plants from the genus Saururus are commonly used to treat inflammatory pathologies. They contain numerous bioactive compounds, notably polycyclic lignan sauchinone species chinensis. An in-depth analysis of benzoxanthenone lignans related sauchinone, and analogous products carpanone polemannones, has been carried out. The review reports product's isolation, biosynthetic pathway, chemical strategies synthesize benzoxanthenones via liquid- solid-phase syntheses. metabolic pharmacokinetic properties discussed. At pharmacological level, is a potent blocker production pro-inflammatory mediators, such as nitric oxide prostaglandin E2, an efficient antioxidant agent. can be exploited combat multiple pathologies, liver injuries, renal dysfunction, osteoarthritis, bowel disease, ulcerative colitis, cancers. capacity natural product inhibit tumor cell proliferation reduce migration/invasion cancer cells development metastases underlined, together with regulation epithelial-mesenchymal transition immune checkpoints. Altogether, offers complete survey biochemical sauchinone-type benzoxanthenones.

Language: Английский

Citations

0
Nanogene editing drug delivery systems in the treatment of liver fibrosis DOI Creative Commons

Qun Wang,

Siyu Jia,

Zihan Wang

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 25, 2024

Liver fibrosis is a group of diseases that seriously affect the health world’s population. Despite significant progress in understanding mechanisms liver fibrogenesis, technologies and drugs used to treat have limited efficacy. As revolutionary genetic tool, gene editing technology brings new hope for treating fibrosis. Combining nano-delivery systems with tools achieve precise delivery efficient expression can be has become rapidly developing field. This review provides comprehensive overview principles methods commonly targets We also discuss recent advances common vehicles formulations research. Although potential advantages fibrosis, it still faces some challenges regarding efficiency, specificity, safety. Future studies need address these issues further explore application

Language: Английский

Citations

2
Sauchinone, an Active Phytochemical of Saururus Chinensis, and its use as therapeutic DOI Creative Commons

Kanika Patel,

Vandana Gupta, Dinesh Kumar Patel

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 12, P. 100486 - 100486

Published: July 24, 2024

Saururus chinensis (Saururaceae) is an important medicinal plant used in traditional Chinese and Korean medicine to treat human diseases. Sauchinone, a lignin from chinensis, reported have numerous pharmacological applications medicine, including anti-oxidant, anti-inflammatory, anti-apoptotic, anti-obesity, hepatoprotective effects. The purpose of this review article describe the scientific information about sauchinone, its medical importance activity order explore potential health benefits sauchinone medicine. In review, all was collected PubMed, Scopus, Science Direct, Google, Google Scholar. Additionally, also described pharmacokinetics understand plasma drug profile with their molecular docking studies. Scientific evidence biological against breast cancer, colorectal gastric hepatocellular carcinoma, liver lung adenocarcinoma, pancreatic ductal osteosarcoma, diabetes, ulcerative colitis, inflammatory bowel disease, osteoarthritis, disorders other complications. studies, parameters were presented know therapeutic value However, mechanisms present significance different kinds demonstrates involved activities detailed preclinical clinical data are still needed research declare efficacy

Language: Английский

Citations

1
Sex differences in pathogenesis and treatment of dyslipidemia in patients with type 2 diabetes and steatotic liver disease DOI Creative Commons

Tatjána Ábel,

Béla Benczúr, Éva Csajbókné Csobod

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 23, 2024

Previously published studies have shown that women with type 2 diabetes a higher risk of atherosclerotic cardiovascular disease than men diabetes. The exact reason for this is not yet known. association between metabolic dysfunction-associated steatotic liver and appears to be bidirectional, meaning the onset one may increase progression other. Dyslipidemia common in both diseases. Our aim was therefore investigate whether there sex difference pathogenesis management dyslipidemia patients dysfunction. While majority date found no statin treatment, some reduced effectiveness compared men. Statin treatment under-prescribed diabetics disease. No differences were ezetimibe treatment. However, best our knowledge, such study fibrate Conflicting results on efficacy newer cholesterol-lowering PCSK9 inhibitors been reported Results from two real-world suggest up-titration dose improves women. Bempedoic acid has effective safe more lipid lowering men, based phase 3 date. Further research needed clarify plays role ASCVD

Language: Английский

Citations

1
Insights into the role of FGF21 in coronary heart disease DOI
Qin-Yao Zhang, Hui‐Xin Liu

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136911 - 136911

Published: Oct. 1, 2024

Language: Английский

Citations

0
miCGR: interpretable deep neural network for predicting both site-level and gene-level functional targets of microRNA DOI Creative Commons
Xiaolong Wu,

Lehan Zhang,

Xiaochu Tong

et al.

Briefings in Bioinformatics, Journal Year: 2024, Volume and Issue: 26(1)

Published: Nov. 22, 2024

Abstract MicroRNAs (miRNAs) are critical regulators in various biological processes to cleave or repress translation of messenger RNAs (mRNAs). Accurately predicting miRNA targets is essential for developing miRNA-based therapies diseases such as cancer and cardiovascular disease. Traditional target prediction methods often struggle due incomplete knowledge miRNA-target interactions lack interpretability. To address these limitations, we propose miCGR, an end-to-end deep learning framework functional targets. MiCGR employs 2D convolutional neural networks alongside enhanced Chaos Game Representation (CGR) both sequences their candidate site (CTS) on mRNA. This advanced CGR transforms genetic into informative graphical representations based sequence composition subsequence frequencies, explicitly incorporates important prior seed regions positions. Unlike one-dimensional solely characters, this approach identifies motifs within sequences, even if they distant the original sequences. Our model outperforms existing at gene levels. enhance interpretability, incorporate Shapley value analysis each sites, allowing miCGR achieve improved accuracy, particularly with more lenient CTS selection criteria. Finally, two case studies demonstrate practical applicability highlighting its potential provide insights optimizing artificial analogs that surpass endogenous counterparts.

Language: Английский

Citations

0