Journal of Biomolecular Structure and Dynamics,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 11
Published: Dec. 18, 2024
Pathogenesis
and
therapeutic
drugs
for
ulcerative
colitis
(UC)
have
plagued
researchers
worldwide.
In
this
study,
targets,
from
Chinese
medicines
UC
were
screened
using
bioinformatics.
We
downloaded
five
datasets
the
GEO
database
three
machine
learning
algorithms
used
screening
diagnostic
biomarkers
of
UC.
Combined
with
differential
genes
UC,
gene
sets
related
to
bile
acid
metabolism,
short-chain
fatty
acids,
apoptosis,
pyroptosis,
G-protein-coupled
receptors,
mitochondria,
autophagy
collected
screen
core
analyze
association
(diagnostic
targets)
immune
cells.
addition,
ingredients
based
on
targets
was
performed.
Molecular
docking,
molecular
dynamics
simulation,
literature
validation
also
The
yielded
37
key
including
5
(CCL11,
CXCL1,
PDZK1IP1,
TIMP1,
UGT2A3)
32
hot
sets.
Immune
cell
infiltration
strongly
associated
in
especially
neutrophils,
macrophages,
mast
cells,
dendritic
Furthermore,
a
total
33
compounds
high
safety
had
been
recognized
as
having
potential
mitigate
by
reverse
prediction
medicines,
reports
preliminarily
validated
results.
Although
further
experimental
is
needed,
work
provides
some
against
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Abstract
Sepsis
is
a
severe
systemic
inflammatory
syndrome
characterized
by
dysregulated
immune
response
to
infection,
often
leading
high
mortality
rates.
The
intestine,
owing
its
distinct
structure
and
physiological
environment,
plays
pivotal
role
in
the
pathophysiology
of
sepsis.
It
functions
as
“central
organ”
or
“engine”
progression
sepsis,
with
intestinal
injury
exacerbating
condition.
Despite
availability
current
therapies
that
offer
partial
symptom
relief,
they
fall
short
adequately
protecting
barrier.
In
this
study,
an
advanced
nanodrug
formulation
(OLA@MΦ
NPs)
developed
coating
macrophage
membranes
onto
polymeric
organic
nanoparticles
encapsulating
olaparib.
When
loaded
into
pH‐responsive
capsules,
intestine‐decipher
engineered
capsule
(cp‐OLA@MΦ
successfully
formulated.
Upon
oral
administration
septic
mice,
these
capsules
withstand
gastric
acid
release
their
contents
specifically
targeting
injured
tissues.
released
OLA@MΦ
NPs
effectively
neutralize
pro‐inflammatory
cytokines
via
membrane
receptors,
while
olaparib
inhibits
epithelial
parthanatos
(a
form
programmed
cell
death)
suppressing
poly(ADP‐ribose)
polymerase
1
(PARP1)
activation.
This
strategy
significantly
reduces
bacterial
translocation,
slows
enhances
survival
thus
presenting
promising
therapeutic
approach
for
sepsis
clinical
applications.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2343 - 2343
Published: July 19, 2024
Hesperetin
(HT)
is
a
type
of
citrus
flavonoid
with
various
pharmacological
activities,
including
anti-tumor,
anti-inflammation,
antioxidant,
and
neuroprotective
properties.
However,
the
role
mechanism
HT
in
ulcerative
colitis
(UC)
have
been
rarely
studied.
Our
study
aimed
to
uncover
beneficial
effects
its
detailed
UC.
Experimental
was
induced
by
2.5%
dextran
sodium
sulfate
(DSS)
for
seven
days.
ameliorated
DSS-induced
mice,
showing
marked
improvement
weight
loss,
colon
length,
colonic
pathological
severity,
levels
TNFα
IL6
serum.
A
combination
informatics,
network
pharmacology,
molecular
docking
identified
eight
key
targets
multi-pathways
influenced
As
highlight,
experimental
validation
demonstrated
that
PTGS2,
marker
ferroptosis,
along
other
indicators
ferroptosis
(such
as
ACSL4,
Gpx4,
lipid
peroxidation),
were
regulated
vivo
vitro.
Additionally,
supplement
increased
diversity
gut
microbiota,
decreased
relative
abundance
Proteobacteria
Gammaproteobacteria,
restored
bacteria
(Lachnospiraceae_NK4A136_group
Prevotellaceae_UCG-001).
In
conclusion,
an
effective
nutritional
against
suppressing
modulating
microbiota.
Brazilian Journal of Medical and Biological Research,
Journal Year:
2025,
Volume and Issue:
58
Published: Jan. 1, 2025
Coptisine
(COP),
a
naturally
occurring
alkaloid,
is
recognized
for
its
varied
pharmacological
impacts
and
supportive
function
in
intestinal
well-being.
However,
the
role
of
COP
to
protect
colonic
epithelium
colitis
has
not
been
extensively
investigated.
The
objective
this
study
was
assess
efficacy
ameliorating
by
investigating
histopathology,
mucosal
barrier
function,
transient
receptor
potential
(TRP)
signaling
pathways
mice
with
colon
disease
compared
control
group,
thereby
elucidating
underlying
mechanisms
action.
results
demonstrated
marked
improvement
diarrhea
bleeding,
an
general
behavioral
competencies
mice,
decrease
activity
index
(DAI)
scores.
Histopathological
analysis
indicated
reduction
inflammation
enhancement
function.
Our
research
identified
that
protein
expressions
TRP
family
including
cation
subfamily
M
member
8
(TRPM8),
vanilloid
1
(TRPV1),
ankyrin
(TRPA1)
were
significantly
upregulated
treatment.
Compared
model,
markedly
downregulated
cytosolic
phospholipase
A2
(cPLA2)
levels,
while
upregulating
calcitonin
gene-related
peptide-1
(CGRP-1)
expressions.
revealed
enhanced
modulating
cPLA2/TRPM8/CGRP-1
pathway,
thus
shedding
light
on
mechanism
which
mitigates
mucosa.
These
findings
provided
new
insights
as
therapeutic
agent
ulcerative
(UC).
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(10), P. 1334 - 1334
Published: Oct. 6, 2024
:
The
role
of
the
gut
microbiome
in
development
and
progression
many
diseases
has
received
increased
attention
recent
years.
Boron,
a
trace
mineral
found
dietary
sources,
attracted
interest
due
to
its
unique
electron
depletion
coordination
characteristics
chemistry,
as
well
potential
modulating
microbiota.
This
study
investigates
effects
inorganic
boron
derivatives
on
microbiota
mice.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1369 - 1369
Published: Nov. 8, 2024
Inflammatory
bowel
diseases
(IBD)
pose
a
growing
public
health
challenge
with
unclear
etiology
and
limited
efficacy
of
traditional
pharmacological
treatments.
Alternative
therapies,
particularly
antioxidants,
have
gained
scientific
interest.
This
systematic
review
analyzed
studies
from
MEDLINE,
Cochrane,
Web
Science,
EMBASE,
Scopus
using
keywords
like
“Inflammatory
Bowel
Diseases”
“Antioxidants.”
Initially,
925
publications
were
identified,
after
applying
inclusion/exclusion
criteria—covering
July
2015
to
June
2024
murine
models
or
clinical
trials
in
humans
evaluating
natural
synthetic
substances
affecting
oxidative
stress
markers—368
articles
included.
comprised
344
animal
24
human
studies.
The
most
investigated
antioxidants
polyphenols
active
compounds
medicinal
plants
(n
=
242;
70.3%).
found
strong
link
between
inflammation
IBD,
especially
on
nuclear
factor
kappa
B
erythroid
2-related
2
pathways.
However,
it
remains
whether
occurs
first
IBD.
Lipid
peroxidation
was
the
studied
damage,
followed
by
DNA
damage.
Protein
damage
rarely
investigated.
relationship
gut
microbiota
examined
103
Human
markers
scarce,
reflecting
major
research
gap
IBD
treatment.
PROSPERO
registration:
CDR42022335357
CRD42022304540.
