Mechanistic Insights into the Pharmacological Significance of Silymarin

Molecules, Journal Year: 2022, Volume and Issue: 27(16), P. 5327 - 5327

Published: Aug. 21, 2022

Medicinal plants are considered the reservoir of diverse therapeutic agents and have been traditionally employed worldwide to heal various ailments for several decades. Silymarin is a plant-derived mixture polyphenolic flavonoids originating from fruits akenes Silybum marianum contains three flavonolignans, silibinins (silybins), silychristin silydianin, along with taxifolin. Silybins major constituents in silymarin almost 70–80% abundance accountable most observed activity. has also acknowledged ancient period utilized European Asian systems traditional medicine treating liver disorders. The contemporary literature reveals that significantly as neuroprotective, hepatoprotective, cardioprotective, antioxidant, anti-cancer, anti-diabetic, anti-viral, anti-hypertensive, immunomodulator, anti-inflammatory, photoprotective detoxification agent by targeting cellular molecular pathways, including MAPK, mTOR, β-catenin Akt, different receptors growth factors, well inhibiting numerous enzymes gene expression apoptotic proteins inflammatory cytokines. Therefore, current review aims recapitulate update existing knowledge regarding pharmacological potential evidenced vast cellular, animal, clinical studies, particular emphasis on its mechanisms action.

Language: Английский

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Promising bioactive properties of quercetin for potential food applications and health benefits: A review

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Nov. 30, 2022

Naturally occurring phytochemicals with promising biological properties are quercetin and its derivatives. Quercetin has been thoroughly studied for antidiabetic, antibacterial, anti-inflammatory, anti-Alzheimer's, anti-arthritic, antioxidant, cardiovascular, wound-healing properties. Anticancer activity of against cancer cell lines also recently revealed. The majority the Western diet contains derivatives, therefore consuming them as part a meal or food supplement may be sufficient people to take advantage their preventive effects. Bioavailability-based drug-delivery systems have heavily studied. Fruits, seeds, vegetables, bracken fern, coffee, tea, other plants all contain quercetin, do natural colors. One naturally antioxidant is whose anticancer effects discussed in detail. It several that could make it an effective anti-cancer agent. Numerous researches shown plays substantial suppression cells breast, colon, prostate, ovary, endometrial, lung tumors. current study includes concise explanation quercetin's action mechanism potential health applications.

Language: Английский

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Recent Advances in Nanoformulations for Quercetin Delivery

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1656 - 1656

Published: June 5, 2023

Quercetin (QUE) is a flavonol that has recently received great attention from the research community due to its important pharmacological properties. However, QUE's low solubility and extended first-pass metabolism limit oral administration. This review aims present potential of various nanoformulations in development QUE dosage forms for bioavailability enhancement. Advanced drug delivery nanosystems can be used more efficient encapsulation, targeting, controlled release QUE. An overview primary nanosystem categories, formulation processes, characterization techniques are described. In particular, lipid-based nanocarriers, such as liposomes, nanostructured-lipid carries, solid-lipid nanoparticles, widely improve absorption increase antioxidant activity, ensure sustained release. Moreover, polymer-based nanocarriers exhibit unique properties improvement Absorption, Distribution, Metabolism, Excretion, Toxicology (ADME(T)) profile. Namely, micelles hydrogels composed natural or synthetic polymers have been applied formulations. Furthermore, cyclodextrin, niosomes, nanoemulsions proposed alternatives administration via different routes. comprehensive provides insight into role advanced

Language: Английский

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Improvement of Therapeutic Value of Quercetin with Chitosan Nanoparticle Delivery Systems and Potential Applications

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3293 - 3293

Published: Feb. 7, 2023

This paper reviews recent studies investigating chitosan nanoparticles as drug delivery systems for quercetin. The therapeutic properties of quercetin include antioxidant, antibacterial and anti-cancer potential, but its value is limited by hydrophobic nature, low bioavailability fast metabolism. Quercetin may also act synergistically with other stronger drugs specific disease states. encapsulation in increase value. Chitosan are a popular candidate preliminary research, the complex nature makes standardisation difficult. Recent have used in-vitro, in-vivo experiments to study alone or combination another active pharmaceutical ingredient encapsulated nanoparticles. These were compared administration non-encapsulated formulation. Results suggest that nanoparticle formulations better. In-vivo animal models simulated type required be treated. types diseases breast, lung, liver colon cancers, mechanical UVB-induced skin damage, cataracts general oxidative stress. reviewed included various routes administration: oral, intravenous transdermal routes. Although toxicity tests often included, it believed loaded needs further researched, especially when not orally administered.

Language: Английский

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Potential of nanoemulsions for accelerated wound healing: innovative strategies

International Journal of Surgery, Journal Year: 2023, Volume and Issue: 109(8), P. 2365 - 2377

Published: May 9, 2023

Wounds represent various significant health concerns for patients and also contribute major costs to healthcare systems. Wound healing comprises of overlapped coordinated steps such as homeostasis, inflammation, proliferation, remodeling. In response the failure many strategies in delivering intended results including wound closure, fluid loss control, exhibiting properties durability, targeted delivery, accelerated action, along with histocompatibility, numerous nanotechnological advances have been introduced. To understand magnitude therapy, this systematic updated review discussing effectiveness nanoemulsions has undertaken. This portrays mechanisms associated healing, factors delayed technologies utilized treat wounds effectively. While are available, attracted tremendous attention scientists globally research therapy due their long-term thermodynamic stability bioavailability. Nanoemulsions not only aid tissue repair, but considered an excellent delivery system synthetic natural actives. Nanotechnology provides several pivotal benefits improved skin permeation, controlled release, stimulation fibroblast cell proliferation. The role preparation techniques highlighted special emphasis on mechanistic insights. article illustrates recent advancements utilization treatment. An adequate literature search conducted using keywords ‘Nanoemulsions healing’, ‘Wound nanoemulsions’, ‘Herbal actives therapy’, ‘Natural oils treatment’ etc., from PubMed, Science Direct, Google Scholar databases. Referred original publications English language accessed till April 2022 included, whereas nonEnglish papers, unpublished data, nonoriginal papers were excluded study.

Language: Английский

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Lipids Fortified Nano Phytopharmaceuticals: A Breakthrough Approach in Delivering Bio-actives for Improved Therapeutic Efficacy

Pharmaceutical Nanotechnology, Journal Year: 2024, Volume and Issue: 13(1), P. 70 - 89

Published: Jan. 26, 2024

Phytopharmaceuticals, derived from natural sources, manifest tremendous potential for therapeutic applications. Nevertheless, effective delivery of these bio-actives presents significant challenges. A breakthrough in fortifying phytopharmaceuticals within phosphatidylcholine is a promising remedy to overcome solubility, permeability, and other related drawbacks. This intrinsic lipid, which obtained both synthetic confers numerous benefits, encompassing heightened augmented bioavailability, enhanced stability. The conjugation with enables improved dermal permeation, absorption, targeted distribution, the possibility synergistic results, eventually improving efficacy. Additionally, use enriched route overcoming limitations imposed by conventional techniques, encouraging more treatments. review provides thorough analysis phosphatidylcholine- incorporated as nanomedicine variables that significantly affect their Moreover, elaborates on how improves tissue distribution boosts phytopharmaceuticals. Further, underscores significance nano-formulation strategies, analytical methodologies, forthcoming prospects propel this field forward. Furthermore, emphasizes inherent innovative approach while highlighting importance additional research endeavors collaborative initiatives unlock benefits phosphatidylcholinefortified phytopharmaceuticals, enhancing patient well-being.

Language: Английский

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Nanoparticle-Encapsulated Plant Polyphenols and Flavonoids as an Enhanced Delivery System for Anti-Acne Therapy

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 209 - 209

Published: Feb. 4, 2025

This study conducted a literature review by searching for articles related to the treatment of skin infections/wrinkles using nano-delivery systems containing natural compounds. The search was in various databases published last 10 years, with strict inclusion and exclusion criteria. Of 490 found, 40 were considered relevant. Acne vulgaris is common dermatological disorder characterised inflammation sebaceous glands, often resulting development pimples, cysts, scarring. Conventional treatments, including antibiotics topical retinoids, frequently demonstrate limitations such as side effects, resistance, insufficient absorption. Recent advancements nanotechnology have enabled creation innovative drug-delivery that enhance effectiveness reduce adverse effects anti-acne medications. Polyphenols flavonoids, bioactive compounds notable anti-inflammatory, antioxidant, antibacterial properties, are recognised their therapeutic acne treatment. However, practical application hindered solubility, stability, bioavailability. incorporation these into nanoparticle-based delivery has shown promise resolving challenges. Various nanoparticle platforms, lipid-based nanoparticles, polymeric solid lipid evaluated ability improve controlled release, targeted polyphenols flavonoids skin. advent polyphenol flavonoid-loaded nanoparticles marks new therapy era.

Language: Английский

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The Significance of Quercetin-Loaded Advanced Nanoformulations for The Management of Diabetic Wounds

Nanomedicine, Journal Year: 2023, Volume and Issue: 18(4), P. 391 - 411

Published: Feb. 1, 2023

Quercetin is a well-known plant flavanol that exhibits multiple biological activities, including antioxidant, anti-inflammatory and anticancer activities. The role of quercetin in wound healing has been widely explored by range researchers different models. However, the physicochemical properties, such as solubility permeability, this compound are low, which ultimately limits its bioavailability on target site. To overcome these limitations for successful therapy, scientists have developed nanoformulations provide effective therapeutic potential. In review, broad mechanism acute chronic wounds covered. A compilation recent advances horizon via incorporated with several advanced nanoformulations.

Language: Английский

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Advancements in wound healing: integrating biomolecules, drug delivery carriers, and targeted therapeutics for enhanced tissue repair

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(4)

Published: April 1, 2024

Language: Английский

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Quercetin as a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues

BioMed Research International, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 37

Published: Feb. 29, 2024

Despite tremendous advances in the prevention and treatment of infectious diseases, only few antiparasitic drugs have been developed to date. Protozoan infections such as malaria, leishmaniasis, trypanosomiasis continue exact an enormous toll on public health worldwide, underscoring need discover novel antiprotozoan drugs. Recently, there has explosion research into properties quercetin, one most abundant flavonoids human diet. In this review, we tried consolidate current knowledge antiprotozoal effects quercetin provide fruitful avenues for future research. Quercetin exerts potent activity against a broad spectrum pathogens Leishmania spp., Trypanosoma Plasmodium Cryptosporidium Trichomonas Toxoplasma gondii. addition its immunomodulatory roles, disrupts mitochondrial function, induces apoptotic/necrotic cell death, impairs iron uptake, inhibits multiple enzymes involved fatty acid synthesis glycolytic pathways, suppresses DNA topoisomerases, downregulates expression various heat shock proteins these pathogens. vivo studies also show that is effective reducing parasitic loads, histopathological damage, mortality animals. Future should focus designing drug delivery systems increase oral bioavailability quercetin. Incorporating nanocarrier would be promising approach manage localized cutaneous infections. Nevertheless, clinical trials are needed validate efficacy treating protozoan

Language: Английский

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