Poison Turned Panacea: Arsenic Trioxide Loaded Hydrogel for Inhibiting Scar Formation in Wound Healing DOI
Xinyue Xu, Youwei Wang, Changhao Han

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(10), P. 6533 - 6544

Published: Sept. 16, 2024

Without intervention, the natural wound healing process can often result in scarring, which have detrimental effects on both physical and mental well-being of patients. Therefore, it is crucial to develop biomaterials that promote without scarring. Regulating Yes-associated protein-1/PDZ-binding motif (YAP/TAZ) signaling pathway possible reduce excessive fibrosis fibroblasts proliferation vascular endothelial cells, ultimately impacting scar formation. Arsenic trioxide (ATO), an ancient drug with medicinal toxic properties, has shown promise regulating this pathway. An ATO-loaded hydrogel dressing (ATO@CS/SA) was created facilitate scarless healing, utilizing chitosan (CS) sodium alginate (SA) prevent direct contact ATO tissue minimize potential side effects. In vitro studies demonstrated low concentrations did not impact cell viability even promoted migration. Co-culturing cells led decreased expression levels YAP TAZ. Animal over a 90-day period revealed significant inhibition formation system. Histological experiments further confirmed TAZ responsible for outcome. conclusion, when administered at appropriate dose, be repurposed from traditional poison therapeutic agent, effectively suppressing blood vessel offering novel approach scar-free treatment.

Language: Английский

Applications and prospects of biomaterials in diabetes management DOI Creative Commons
Wei‐jie Guan, Liang Zhang

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 7, 2025

Diabetes is a widespread metabolic disorder that presents considerable challenges in its management. Recent advancements biomaterial research have shed light on innovative approaches for the treatment of diabetes. This review examines role biomaterials diabetes diagnosis and treatment, as well their application managing diabetic wounds. By evaluating recent developments alongside future obstacles, highlights promising potential care, underscoring importance enhancing patient outcomes refining methodologies.

Language: Английский

Citations

0
Extraction, purification, structural features, biological activities, and applications of polysaccharides from Opuntia ficus-indica (L.) Mill. (cactus): a review DOI Creative Commons

Xudong Liu,

Xing Yan, Guijun Liu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 12, 2025

Cactus has attracted increasing attention from researchers due to its rich nutritional, edible, and medicinal value. contains abundant polysaccharides, polyphenols, vitamins, amino acids, minerals, more. Among them, polysaccharides are considered as important bioactive components in cactus. In the past period, have been isolated cactus through various methods their structures also studied. Some vivo vitro experimental results indicate that promoting wound healing, anti-inflammatory, immune regulation, anti-glycosylation, antioxidant effects. This article reviews research progress extraction, purification, structural characteristics, biological activities of recent years. addition, relationship between structure activity was discussed. review provides basis latest information for in-depth development application multiple fields such medicine functional foods.

Language: Английский

Citations

0
Spectro-Thermal Characterization, DFT Calculations and Antimicrobial Activities of Oxime Ligand and Its Mn(II) & Co(II) Metal Complexes DOI Open Access
Reema Chand, M.F. Ahmed,

Bibhesh K. Singh

et al.

Journal of Advanced Chemical Sciences, Journal Year: 2025, Volume and Issue: 11(1), P. 832 - 837

Published: March 16, 2025

An appropriate conventional method was employed to synthesize a new oxime-based ligand, 2,4-dihydroxybenzaldehyde oxime, and its transition metal (II) complexes with Mn Co ions. The coordination behavior, bonding nature, crystal structures of these were elucidated using spectroscopic techniques, including FT-IR, UV-Visible, powder X-ray diffraction. UV-Visible spectral analysis suggests that both exhibit an octahedral geometry. Additionally, molecular modeling through Density Functional Theory (DFT) calculations provided detailed insights into their electronic properties, stability trends, potential reactivity. optimized structural parameters, bond lengths angles, determined DFT the B3LYP functional 6-31G**, 6-311G**(d,p), LanL2DZ basis sets.

Language: Английский

Citations

0
Bioactive Hydrogels (Bio‐HyGs): Emerging Trends in Drug Delivery and Wound Healing Applications DOI Open Access
Natesan Thirumalaivasan, Kuppusamy Kanagaraj, Senthilkumar Nangan

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)

Published: March 31, 2025

ABSTRACT This review on bioactive Hydrogels (Bio‐HyGs) synthesizes current advancements in their design and utilization, particularly emphasizing roles drug delivery wound healing. Bio‐HyGs, including gelatin methacrylate (GM), polyethylene glycol (PEG), poly(vinyl alcohol) (PVA), are highlighted for effectiveness treating chronic wounds like diabetic pressure ulcers, leveraging moisture retention tissue regeneration capabilities. These hydrogels designed the controlled release of compounds such as vascular endothelial growth factor (VEGF) platelet‐derived (PDGF), thereby facilitating healing without need initial cell seeding. The also covers embedded with antimicrobial agents silver nanoparticles quaternized chitosan, which crucial managing infected wounds. Additionally, thermoresponsive that respond to temperature changes application self‐assembling peptides 3D printing discussed contributions mimicking biological tissues, enhance both aims provide a comprehensive understanding structural functional modifications exploring potential transforming clinical outcomes treatment systems.

Language: Английский

Citations

0
Evaluation of the Pro-Angiogenic Effect in Chicken Embryo Chorioallantoic Membrane (CAM) Model and the In Vivo Wound Healing Potential of the Moroccan Polysaccharide-Rich Algae Osmundea pinnatifida DOI Open Access

Bengaly Zakaria,

Malek Eleroui, Ben Saad Hajer

et al.

Published: Oct. 23, 2024

Various methods have been studied to speed up the wound healing process. Promoting rapid development of blood vessels, also known as angiogenesis, is essential this significantly accelerates skin regeneration. This study identified a polysaccharide from red alga Osmundea pinnatifida (PSOP) that promotes angiogenesis and healing. Firstly, we analyzed structural characteristics PSOP using various techniques such UV-visible spectrum, Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (X-RD), scanning electron microscopy (SEM), high-performance liquid chromatography coupled refractive index detector (HPLC-RID). We evaluated antioxidant properties in vitro tests for DPPH free radical scavenging capacity, iron reduction capacity (RPA), total (TAC). Additionally, observed significant increase new vessel formation chorioallantoic membrane model (CAM assay) fertilized hen egg, indicating pro-angiogenic effect PSOP. Furthermore, tested wound-healing potential hydrogel vivo excision wounds Wistar rat model. The results showed notable acceleration closure an improvement tissue regeneration collagen deposition quality within 11 days, strong activity Our computational suggested units bind cyclooxygenase 2 (COX-2) vascular endothelial growth factor (VEGF) with acceptable affinities interactions, which might explain beneficial seen experimental assays. findings support treatment due its potential.

Language: Английский

Citations

1
Advances in Mesenchymal Stem Cell Therapy and Natural Antioxidants for Hepatic Fibrosis: A Comprehensive Review DOI
Abeer Kazmi, Tahira Sultana

Deleted Journal, Journal Year: 2024, Volume and Issue: 2, P. 100016 - 100016

Published: March 1, 2024

Liver damage resulting from the administration of various allopathic drugs and their associated toxicity has become a major health problem, leading to hepatic fibrosis, cirrhosis, metabolic disorders. This epidemic condition liver disease represents global cause death morbidity. Although orthotopic transplantation remains vital treatment option for fibrotic conditions, its efficacy is limited by organ scarcity risk immunological rejection. Consequently, alternative therapeutic approaches are urgently needed. Cell-based therapy utilizing mesenchymal stem cells (MSCs) garnered considerable interest as promising modality. MSCs exhibit immunomodulatory properties can differentiate into hepatocytes, thus facilitating regeneration damaged hepatocytes increasing residual hepatocyte proliferation while inhibiting activation or apoptosis stellate cells. However, despite potential benefits, transplanted often low survival rates due inadequate oxidative inflammatory stress resistance. Plants harbor diverse array bioactive compounds known possess hepatoprotective antioxidant properties. Nanomaterials play crucial role in regenerative medicine providing targeted delivery agents scaffolds tissue engineering. In treating liver, nanomaterials help mitigate fibrosis progression promote through controlled release anti-fibrotic growth factors. review highlights synergistic cell-based therapy, natural antioxidants, differentiation factors, nanotechnology combating advancing medicine. These combined offer avenues effectively conditions promoting regeneration.

Language: Английский

Citations

0
Poison Turned Panacea: Arsenic Trioxide Loaded Hydrogel for Inhibiting Scar Formation in Wound Healing DOI
Xinyue Xu, Youwei Wang, Changhao Han

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(10), P. 6533 - 6544

Published: Sept. 16, 2024

Without intervention, the natural wound healing process can often result in scarring, which have detrimental effects on both physical and mental well-being of patients. Therefore, it is crucial to develop biomaterials that promote without scarring. Regulating Yes-associated protein-1/PDZ-binding motif (YAP/TAZ) signaling pathway possible reduce excessive fibrosis fibroblasts proliferation vascular endothelial cells, ultimately impacting scar formation. Arsenic trioxide (ATO), an ancient drug with medicinal toxic properties, has shown promise regulating this pathway. An ATO-loaded hydrogel dressing (ATO@CS/SA) was created facilitate scarless healing, utilizing chitosan (CS) sodium alginate (SA) prevent direct contact ATO tissue minimize potential side effects. In vitro studies demonstrated low concentrations did not impact cell viability even promoted migration. Co-culturing cells led decreased expression levels YAP TAZ. Animal over a 90-day period revealed significant inhibition formation system. Histological experiments further confirmed TAZ responsible for outcome. conclusion, when administered at appropriate dose, be repurposed from traditional poison therapeutic agent, effectively suppressing blood vessel offering novel approach scar-free treatment.

Language: Английский

Citations

0