Phytosomes: nature’s secret to enhanced bioavailability DOI Creative Commons

M Surendra Kumar,

K. Dhivya,

Dasari Lokesh

et al.

Journal of Applied Pharmaceutical Research, Journal Year: 2024, Volume and Issue: 12(6), P. 88 - 99

Published: Dec. 31, 2024

Background: Medicinal herbs have long been used for treating various ailments, with plant-derived compounds recognized their therapeutic benefits and minimal side effects compared to conventional medicines. However, issues the bioavailability of active herbal components limited effectiveness. Phytosomes, or herbosomes, are a drug delivery technology that enhances absorption these plant-based compounds, providing potential solution maximizing medicinal efficacy ingredients. Method: Phytosome complexes synthesized by combining plant extracts phospholipids in specific molar ratios, typically 1:1, create more stable bioavailable formulation. Common preparation methods include solvent evaporation, supercritical fluid extraction, lyophilization. Each technique is optimized improve stability, solubility, action phytosomes. Results discussion: has shown significant improvements phytochemicals, such as silymarin curcumin, enhancing pharmacological effects. Applications phytosomes span areas, including cancer treatment, rheumatism, wound healing, respiratory conditions. Studies indicate absorption, targeted delivery, effectively managing complex diseases reduced Conclusion: Phytosomes represent promising advancement natural medicine addressing challenges associated compounds. The improved formulation techniques broad applications suggest bright future phytosome-based therapies, especially areas where treatments may limitations. Further research development phytosome could lead enhanced clinical outcomes expand use remedies modern medicine.

Language: Английский

Recent Advances in Metal–Organic Framework-Based Anticancer Hydrogels DOI Creative Commons
Preeti Kush, Ranjit Singh, Parveen Kumar

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 76 - 76

Published: Jan. 18, 2025

Cancer is the second leading cause of death globally and estimated number new cancer cases deaths will be ∼30.2 million 16.3 million, respectively, by 2040. These numbers massive, physical, emotional, financial burdens to society healthcare system that lead further research for a better more effective therapeutic strategy manage cancer. Metal–organic frameworks (MOFs) are promising alternative approaches efficient drug delivery theranostics owing their unique properties direct transportation drugs into cells followed controlled release, but they suffer from certain limitations like rigidity, poor dispersibility, fragility, aggregation probability, limited surface accessibility. Therefore, MOFs were conjugated with polymeric hydrogels, formation MOF-based hydrogels abundant absorption sites, flexibility, excellent mechanical properties. This review briefly describes different strategies used synthesis characterization hydrogels. Further, we place special emphasis on recent advances in cancers. Finally, conclude challenges future perspectives We believe this help researchers develop augmented anticancer effects, enabling management even without adverse effects.

Language: Английский

Citations

1
Phytosomes: A Promising Nanocarrier System for Enhanced Bioavailability and Therapeutic Efficacy of Herbal Products DOI Creative Commons
Marjan Talebi,

Kimia Shahbazi,

Mohammad Sedigh Dakkali

et al.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100779 - 100779

Published: March 1, 2025

Language: Английский

Citations

1
Transforming cancer treatment: The potential of nanonutraceuticals DOI Creative Commons
Girish Kumar, Tarun Virmani,

Vaishnavi Chhabra

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 667, P. 124919 - 124919

Published: Nov. 7, 2024

Language: Английский

Citations

5
Emerging phytochemical-based nanocarriers: redefining the perspectives of breast cancer therapy DOI
Gulshan Sharma,

Rohil Panwar,

Sangeeta Saini

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

Citations

0
Preparing a Phytosome for Promoting Delivery Efficiency and Biological Activities of Methyl Jasmonate-Treated Dendropanax morbifera Adventitious Root Extract (DMARE) DOI Creative Commons
Fengjiao Xu,

Shican Xu,

Yang Li

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1273 - 1273

Published: Oct. 10, 2024

(1) Background: Methyl jasmonate-treated

Language: Английский

Citations

2
Phytosomes: nature’s secret to enhanced bioavailability DOI Creative Commons

M Surendra Kumar,

K. Dhivya,

Dasari Lokesh

et al.

Journal of Applied Pharmaceutical Research, Journal Year: 2024, Volume and Issue: 12(6), P. 88 - 99

Published: Dec. 31, 2024

Background: Medicinal herbs have long been used for treating various ailments, with plant-derived compounds recognized their therapeutic benefits and minimal side effects compared to conventional medicines. However, issues the bioavailability of active herbal components limited effectiveness. Phytosomes, or herbosomes, are a drug delivery technology that enhances absorption these plant-based compounds, providing potential solution maximizing medicinal efficacy ingredients. Method: Phytosome complexes synthesized by combining plant extracts phospholipids in specific molar ratios, typically 1:1, create more stable bioavailable formulation. Common preparation methods include solvent evaporation, supercritical fluid extraction, lyophilization. Each technique is optimized improve stability, solubility, action phytosomes. Results discussion: has shown significant improvements phytochemicals, such as silymarin curcumin, enhancing pharmacological effects. Applications phytosomes span areas, including cancer treatment, rheumatism, wound healing, respiratory conditions. Studies indicate absorption, targeted delivery, effectively managing complex diseases reduced Conclusion: Phytosomes represent promising advancement natural medicine addressing challenges associated compounds. The improved formulation techniques broad applications suggest bright future phytosome-based therapies, especially areas where treatments may limitations. Further research development phytosome could lead enhanced clinical outcomes expand use remedies modern medicine.

Language: Английский

Citations

0