Drug and Alcohol Dependence, Journal Year: 2020, Volume and Issue: 212, P. 107985 - 107985
Published: April 27, 2020
Language: Английский
Cells, Journal Year: 2020, Volume and Issue: 9(5), P. 1196 - 1196
Published: May 12, 2020
Targeting peroxisome proliferator-activated receptors (PPARs) has received increasing interest as a potential strategy to treat substance use disorders due the localization of PPARs in addiction-related brain regions and ability PPAR ligands modulate dopamine neurotransmission. Robust evidence from animal models suggests that agonists at both PPAR-α PPAR-γ isoforms can reduce positive negative reinforcing properties ethanol, nicotine, opioids, possibly psychostimulants. A reduction voluntary consumption ethanol following treatment with seems be most consistent finding. However, human is limited scope so far been less promising. There have no published trials for alcohol disorder, despite compelling preclinical evidence. Two smoking cessation drugs found effect on nicotine-related outcomes. The agonist pioglitazone showed some promise reducing heroin, cocaine craving two laboratory studies one pilot trial, yet other outcomes were unaffected. Potential explanations discordance between evidence, such potency selectivity sex-related variability physiology, are discussed.
Language: Английский
Citations
32
Social Cognitive and Affective Neuroscience, Journal Year: 2020, Volume and Issue: 15(7), P. 789 - 801
Published: July 1, 2020
Abstract Several studies have suggested that females and males differ in reward behaviors their underlying neural circuitry. Whether human sex differences extend across behavioral levels for both rewards punishments remains unclear. We studied a community sample of 221 young women men who performed monetary incentive task known to engage the mesoaccumbal pathway salience network. Both stimulus (behavioral relevance) valence (win vs loss) varied during task. In response high- low-salience stimuli presented task, showed greater subjective arousal ratings, accuracy skin conductance responses (P < 0.006, Hedges’ effect size g = 0.38 0.46). subsample with functional magnetic resonance imaging (n 44), exhibited responsiveness nucleus accumbens, midbrain, anterior insula dorsal cingulate cortex 0.02, 0.86 1.7). Behavioral, autonomic sensitivity did not by sex, indicating were similar men. These results reveal novel robust reward- punishment-related traits, behavior, activity responses. convergent suggest neurobehavioral basis sexual dimorphism observed system, including reward-related disorders.
Language: Английский
Citations
31
CNS Drugs, Journal Year: 2018, Volume and Issue: 32(5), P. 421 - 435
Published: May 1, 2018
Language: Английский
Citations
32
Medicines, Journal Year: 2022, Volume and Issue: 9(3), P. 19 - 19
Published: March 1, 2022
Background: Novel psychoactive substances (NPS) are compounds of natural and synthetic origin, similar to traditional drugs abuse. NPS involved in a contemporary trend whose origin lies thinner balance between legitimate therapeutic drug research legislative control. The resulted from the replacement MDMA by cathinones ‘ecstasy’ during 2000s. most common cannabinoids cathinones. Interestingly, last 50 years, these two classes have been object scientific for set health conditions. Methods: Searches were conducted online database PubMed using boolean equations. Results: Synthetic displayed protective effects inflammatory, neurodegenerative oncologic pathologies, activating immune system reducing inflammation. act similarly amphetamine-type stimulants can be used depression chronic fatigue. Conclusions: Despite advances this field research, pharmacological application is being jeopardized fatalities associated with their recreational use. This review addresses achievements toxicological data, ending reflection on Illicit control frames.
Language: Английский
Citations
15
Journal of Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Background: Migraine and cluster headache are two primary disorders for which conventional treatments limited. Classic psychedelic substances such as lysergic acid diethylamide (LSD) psilocybin potentially promising new treatment candidates these conditions. Aims: The aim of the present study was to investigate possible relationship between lifetime use classic psychedelics frequent bad headaches in a large British cohort sample. Methods: Using data ( N = 11,419) collected 1999–2000 part 1958 National Child Development Study, this cross-sectional used multiple logistic regression, controlling range potential confounders, test hypothesis that would be associated with lower odds having headaches. Results: Lifetime 25% (adjusted ratio 0.75, 95% CI: 0.59–0.95, p 0.016). Conclusions: results add literature suggesting future prophylactic option disorders.
Language: Английский
Citations
0
International Journal of Developmental Neuroscience, Journal Year: 2020, Volume and Issue: 80(5), P. 396 - 408
Published: May 16, 2020
Exposure to enriched environment (EE) has been indicated enhance cognitive functions, hippocampal neural plasticity, neurogenesis, long-term potentiation, and levels of the brain-derived neurotrophic factor (BDNF) in laboratory animals. Also, studies on sex-dependent effects exposure EE during adolescence adult functions are less. This is important because beneficial may be predominant stage. Therefore, present study was designed compare (PND21-PND60) novel objective recognition memory (NORM), anxiety-like behaviors, BDNF mRNA level male female rats. Assessment NORM behaviors done by task, open field (OF), elevated plus maze (EPM), respectively. The expression also evaluated quantitative RT-PCR. Our findings demonstrated that housing improves had a different effect both sexes. Additionally, our results an augmented hippocampus In conclusion, adolescent increases rats; thus, can mediate running exercise psychiatric traits.
Language: Английский
Citations
23
Current Pharmaceutical Design, Journal Year: 2020, Volume and Issue: 26(20), P. 2334 - 2352
Published: Feb. 6, 2020
As manifestations of excessive and uncontrolled intake, obesity drug addiction have generated much research aimed at identifying common neuroadaptations that could underlie both disorders. Much work has focused on changes in brain reward motivational circuitry can overexcite eating drug-taking behaviors. We suggest the regulation behaviors depends balancing excitation produced by stimuli associated with food rewards behavioral inhibition physiological "satiety" other signal when those are unavailable. Our main hypothesis is dysregulated use consequences diet- drug-induced degradations this inhibitory power. first outline a learning memory mechanism drug-intake, we describe data identifies hippocampus as substrate for mechanism. then present evidence obesitypromoting western diets (WD) impair operation process generate pathophysiologies disrupt hippocampal functioning. Next, parallel drugs abuse also same similar pathophysiologies. recent findings prior WD intake elevates self-administration, implications using (i.e., glucagon-like peptide- 1 agonists) enhance functioning to treat considered. conclude description how initiate "vicious-cycle" pathophysiology impaired hippocampal-dependent inhibition.
Language: Английский
Citations
21
Brain Sciences, Journal Year: 2022, Volume and Issue: 12(3), P. 388 - 388
Published: March 15, 2022
Gender differences in psychiatric disorders and drug use are well known. Cannabis is the most widely used illegal among young people. In recent years, its has been related to development of pathologies; however, few studies have incorporated gender perspective as yet. The present work analyses literature determine existence psychotic, depressive anxious symptoms associated with cannabis use. First, we describe misuse consequences, paying special attention adolescent subjects. Second, main disorders, such psychosis, depression, anxiety enumerated. Subsequently, discuss that evaluated association between appearance symptoms; moreover, consider possible explanations for identified differences. conclusion, referred this review reveal use, although direction not always clear. Future research necessary discern causal relationship symptoms, found.
Language: Английский
Citations
14
Behavioural Neurology, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 27
Published: April 20, 2022
Drug use and abuse are complex issues in that the basis of each may involve different determinants consequences, transition from one to other be equally multifaceted. A recent model addiction cycle (as proposed by Koob his colleagues) illustrates how drug-taking patterns impulsive (acute use) compulsive (chronic as a function various neuroadaptations leading downregulation DA systems, upregulation stress dysregulation prefrontal/orbitofrontal cortex. Although nature reinforcement initiation mediation these effects differ (positive vs. negative), role drug intake chronic) is well characterized. However, drugs have stimulus properties important their abuse. One such property aversive limit instead initiating maintaining it. Evidence comes both clinical preclinical populations. In support this position, present review describes (assessed primarily conditioned taste aversion learning), fact they occur concurrently with reward assessed combined aversion/place preference designs, (in balance rewarding effects), dissociation affective can affected ways same manipulations, impact parametric, experiential, subject factors on consequent potential.
Language: Английский
Citations
14
Cell Reports, Journal Year: 2023, Volume and Issue: 42(6), P. 112553 - 112553
Published: May 23, 2023
Understanding mesolimbic dopamine adaptations underlying vulnerability to drug relapse is essential inform prognostic tools for effective treatment strategies. However, technical limitations have hindered the direct measurement of sub-second release in vivo prolonged periods time, making it difficult gauge weight that these abnormalities determining future incidence. Here, we use fluorescent sensor GrabDA record, with millisecond resolution, every single cocaine-evoked transient nucleus accumbens (NAc) freely moving mice during self-administration. We reveal low-dimensional features patterned are strong predictors cue-induced reinstatement cocaine seeking. Additionally, report sex-specific differences cocaine-related responses related a greater resistance extinction males compared females. These findings provide important insights into sufficiency NAc signaling dynamics-in interaction sex-for recapitulating persistent seeking and vulnerability.
Language: Английский
Citations
8