SIRT3 Regulates H3K9Ac Modification to Affect DDIT4 Involved in Abnormal Hepatic Lipid Metabolism in Male Offspring of Paternal High‐Fat Diet

Journal of Food Biochemistry, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Studies indicate that the male environment and feeding patterns may impact offspring. In this study, a paternal high‐fat diet (HFD) model was established to investigate lipid metabolism of We found HFD‐F1 mice exhibited abnormal hepatic gluconeogenesis in intraperitoneal pyruvate tolerance test (IPPTT) increased deposition liver. Additionally, contents triglyceride (TG) low‐density lipoprotein cholesterol (LDL‐C) plasma liver tissues were significantly elevated mice. Transcriptome analysis revealed upregulation genes involved adipogenesis, such as Ddit4 , downregulation oxidative phosphorylation‐related like Nmrk1 . Western blotting confirmed decreased SIRT3 expression, DDIT4 reduced AKT phosphorylation AML12 cells, knockdown Sirt3 led expression phosphorylation, while overexpression had opposite effect vitro. Notably, H3K9Ac Furthermore, changes influenced levels H3K9Ac. ChIP‐qPCR assays demonstrated significant increase binding promoter conclusion, our findings highlight role SIRT3‐H3K9Ac‐DDIT4‐AKT pathway mediating offspring HFD. These results provide new mechanistic insights into epigenetic regulation molecular basis dysregulation suggest potential targets for therapeutic intervention.

Language: Английский

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Preconception and/or preimplantation exposure to a mixture of environmental contaminants altered fetoplacental development and placental function in a rabbit model.

Environmental Research, Journal Year: 2024, Volume and Issue: 262, P. 119829 - 119829

Published: Aug. 22, 2024

Language: Английский

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A systematic review exploring evidence for adolescent understanding of concepts related to the developmental origins of health and disease

Journal of Developmental Origins of Health and Disease, Journal Year: 2023, Volume and Issue: 14(6), P. 755 - 762

Published: Dec. 1, 2023

Abstract The developmental origins of health and disease (DOHaD) framework has highlighted the importance early life period on risk in later with impacts that can span generations. A primary focus to date been around maternal ‘First Thousand Days’ as a key window whereby an adverse environment have lasting both mother offspring. More recently, impact paternal gathered increasing traction for programming. However, date, adolescents, next generation parents, attracted less attention DOHaD although many behavioural traits become entrained during adolescence track into adulthood. This systematic review examined literature focused identifying adolescent understanding concepts. Consistent across eligible articles was overall DOHaD-related concepts adolescents low. Three themes emerged: 1. Individual-level awareness (cognitive engagement action themselves); 2. Interpersonal communication social family wider community); 3. Health literacy promotion stage. These findings highlight need develop strategic approaches increase are not only appealing but also support sustained changes behaviour. Investment today’s potential act NCD ‘circuit breaker’ thus will yield significant dividends future

Language: Английский

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Paternal age and first trimester placental size and growth: The Rotterdam Periconceptional Cohort

Placenta, Journal Year: 2024, Volume and Issue: 150, P. 1 - 7

Published: March 22, 2024

Despite a noticeable trend of delayed fatherhood, less is known about the impact paternal age on paternally programmed placenta. We hypothesize that aging affects seminal quality and as such induces ageing-related epigenetic alterations influence placental growth. Our main aim to investigate associations between first trimester (vascular) growth trajectories.

Language: Английский

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Understanding DOHaD Concepts Among New Zealand Adolescents: A Qualitative Exploration of Knowledge, Intervention Windows, and Information Accessibility

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(12), P. 1556 - 1556

Published: Nov. 25, 2024

The Developmental Origins of Health and Disease (DOHaD) framework has highlighted the role maternal paternal health on disease risk in offspring across generations. Although adolescence is increasingly recognised as a key DOHaD window where interventions may have greatest impact breaking cycle non-communicable diseases, data around recognition this concept adolescents remain limited. Previous work by our group found that understanding DOHaD-related concepts among New Zealand was low, including some showing disagreement with concepts. This qualitative study aimed to explore perspectives understandings who responded survey using semi-structured focus groups interviews (n = 12). Four core themes were identified: 1. knowledge terminology; 2. different life course windows for interventions; 3. recognising information needs be accessible adolescents; 4. importance developing context-specific resources adolescents. Adolescents indicated they had not heard or related terminology. majority there many important stages potential interventions, strong emphasis opportunity. suggested more could done schools help promote awareness during later years schooling. development future contextually specific ensure increased uptake developmental window.

Language: Английский

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Paternal obesity decreases infant MSC mitochondrial functional capacity

AJP Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 327(4), P. E441 - E448

Published: Aug. 14, 2024

Paternal obesity decreases infant mesenchymal stem cell (MSC) basal and maximal respiration. Lower OXPHOS electron transport system capacity could be explained by lower complex I IV respiratory but not changes in expression MSC from fathers with obesity. altered mitochondrial functional are associated a greater weight-to-length ratio at birth.

Language: Английский

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