Causality of unsaturated fatty acids and psoriasis a Mendelian randomization study DOI Creative Commons
Junchen Li, Qian Shen, Chenqi Guo

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 9, 2024

Background Many observational studies have identified a link between unsaturated fatty acids and psoriasis. However, they contain reverse causality confounding factors, there is no definite causal study Objectives Analysis of psoriasis by Mendelian randomization. Methods We used IEU Open GWAS Project, omega-3 PUFA omega-6 data from 114,999 subjects, MUFA 13,535 4,510 cases 212,242 controls were included. employed the inverse-variance weighted (IVW) method as primary analytical approach four additional MR methods. Moreover, we performed heterogeneity horizontal pleiotropy assessments using Cochrane’s Q MR-Egger intercept tests, respectively. Finally, sensitivity analyses to enhance our findings’ precision veracity. Results IVW results showed effect on ( p = 0.334; OR, 0.909; 95% CI, 0.748–1.104), cause 0.046; 1.174; 1.003–1.374), 0.032; 1.218; 1.018–1.457), in 0.695; 0.989; 0.937–1.044), 0.643; 1.013; 0.960–1.068), not 0.986; 1.000; 0.949–1.055). Heterogeneity, pleiotropy, reliable results. Conclusion found that circulating psoriasis, while do not. Treatments lower are effective After better understanding acid intake circulation, population can be advised regulate their diet.

Language: Английский

Acylated Flavonoids from Cucumis sativus Inhibit the Activity of Human Pancreatic Lipase DOI Creative Commons
Д. Н. Оленников, N. I. Kashchenko

Applied Biochemistry and Microbiology, Journal Year: 2023, Volume and Issue: 59(4), P. 530 - 538

Published: Aug. 1, 2023

Abstract Lipid metabolism disorders are a large group of diseases for the treatment which various strategies used, including use pancreatic lipase inhibitors that reduce intake and adsorption lipids. This study was first shows agricultural wastes cucumber ( Cucumis sativus ) can be source effective inhibitors. As result chromatographic separation metabolites in C. leaves, seven acylated flavonoids were identified, three new derivatives isovitexin characterized by UV, NMR spectroscopy mass spectrometry data as isovitexin-2"- O -glucoside-6"- -ferulate 1 ), - p -coumarate 2 -(6"- -feruloyl)-glucoside-6"- 3 ). The quantitative HPLC showed total content leaves Russian varieties amounted to 3.78–7.44 mg/g dry plant weight. Isolated compounds demonstrated ability inhibit human lipase; effectiveness compound greatest exceeded activity reference Orlistat. has shown useful biologically active phytocomponents with hypolipidemic activity.

Language: Английский

Citations

13
Milk polar lipids: Untapped potential for pharmaceuticals and nutraceuticals DOI

Aditi Pawar,

Ioannis Zabetakis,

Tanvi Gavankar

et al.

PharmaNutrition, Journal Year: 2023, Volume and Issue: 24, P. 100335 - 100335

Published: March 1, 2023

Language: Английский

Citations

11
Lipid analysis of meat from Bactrian camel (Camelus bacterianus), beef, and tails of fat-tailed sheep using UPLC-Q-TOF/MS based lipidomics DOI Creative Commons
Qingqing Li, Li Yang, Rongrong Li

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: March 2, 2023

Introduction As a source of low-cost and high-quality meat for human beings, the consumption camel was increasing, beef has similar texture nutritional characteristics with meat. Camel hump fatty-tails are important parts fat storage camels fat-tailed lambs, respectively, which were to adapt endure harsh environments. Considering their physiological functions, composition might be similar. Lipidomics is system-level analysis lipids method, play an role in determination quantification individual lipid molecular specie, food adulteration labeling. Methods A GC/MS used analyze fatty acids Xinjiang Bactrian meat, hump, beef, fatty-tails. UPLC-Q-TOF/MS based on lipidomics approach composition, characterize examine differences Results discussion The major four samples C16:0, C18:0, C18:1 cis , had significant low SFA content high MUFA content. total 342 species detected, 192, 64, 79 distinguishing found groups compared fatty-tails, respectively. Lipid metabolisms ether lipid, glycerophospholipid, glycerolipid, sphingolipid most influential pathways revealed by KEGG analysis. results contributed enrich information indicated that alternative method distinguish samples.

Language: Английский

Citations

11
The Antioxidant Effect of Dietary Bioactives Arises from the Interplay between the Physiology of the Host and the Gut Microbiota: Involvement of Short-Chain Fatty Acids DOI Creative Commons
Rossana Cuciniello, Francesco Di Meo, Stefania Filosa

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1073 - 1073

Published: May 10, 2023

The maintenance of redox homeostasis is associated with a healthy status while the disruption this mechanism leads to development various pathological conditions. Bioactive molecules such as carbohydrates accessible microbiota (MACs), polyphenols, and polyunsaturated fatty acids (PUFAs) are food components best characterized for their beneficial effect on human health. In particular, increasing evidence suggests that antioxidant ability involved in prevention several diseases. Some experimental data indicate activation nuclear factor 2-related erythroid 2 (Nrf2) pathway—the key homeostasis—is effects exerted by intake PUFAs polyphenols. However, it known latter must be metabolized before becoming active intestinal play role biotransformation some ingested components. addition, recent studies, indicating efficacy MACs, microbial population yield biologically metabolites (e.g., polyphenol metabolites, short-chain (SCFAs)), support hypothesis these factors responsible action physiology host. underlying mechanisms through which might influence have not been fully elucidated, but based SCFAs Nrf2 activators, contribution dietary bioactives cannot excluded. review, we aimed summarize main can modulate host’s directly or indirectly activate pathway. We discuss probiotic played alteration metabolism/composition gut generation potential Nrf2-ligands SCFAs) homeostasis.

Language: Английский

Citations

11
Causality of unsaturated fatty acids and psoriasis a Mendelian randomization study DOI Creative Commons
Junchen Li, Qian Shen, Chenqi Guo

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 9, 2024

Background Many observational studies have identified a link between unsaturated fatty acids and psoriasis. However, they contain reverse causality confounding factors, there is no definite causal study Objectives Analysis of psoriasis by Mendelian randomization. Methods We used IEU Open GWAS Project, omega-3 PUFA omega-6 data from 114,999 subjects, MUFA 13,535 4,510 cases 212,242 controls were included. employed the inverse-variance weighted (IVW) method as primary analytical approach four additional MR methods. Moreover, we performed heterogeneity horizontal pleiotropy assessments using Cochrane’s Q MR-Egger intercept tests, respectively. Finally, sensitivity analyses to enhance our findings’ precision veracity. Results IVW results showed effect on ( p = 0.334; OR, 0.909; 95% CI, 0.748–1.104), cause 0.046; 1.174; 1.003–1.374), 0.032; 1.218; 1.018–1.457), in 0.695; 0.989; 0.937–1.044), 0.643; 1.013; 0.960–1.068), not 0.986; 1.000; 0.949–1.055). Heterogeneity, pleiotropy, reliable results. Conclusion found that circulating psoriasis, while do not. Treatments lower are effective After better understanding acid intake circulation, population can be advised regulate their diet.

Language: Английский

Citations

4