The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications DOI Creative Commons

Jennifer Schild,

Aneta Kalvodová, Jarmila Zbytovská

et al.

International Journal of Cosmetic Science, Journal Year: 2024, Volume and Issue: 46(4), P. 526 - 543

Published: Aug. 1, 2024

Abstract Ceramides are a family of lipids constituted by sphingoid base and fatty acid. In the skin, they mainly present in stratum corneum where, with cholesterol free acids, constitute inter‐corneocyte lipids. With other lipid groups, play key role formation dense lamellar structures between adjacent corneocytes, collectively ensuring vital efficient barrier to water evaporation protection from foreign agents´ penetration. Changes ceramide level relative composition, potential impairment arrangement, have been evidenced different skin conditions diseases. Therefore, use suitably formulated ceramides has proposed for topical treatment help re‐structure damaged arrangement repair impaired function. Nonetheless, formulation products necessitates specific processes such as heating high temperature before their introduction final formula. this review on structure, skincare, we point out necessity rigorous process when formulating into product. We demonstrate counterproductive effects undissolved capacity formulas, assessed vitro models disrupted barrier.

Language: Английский

Nanotechnology strategies to address challenges in topical and cellular delivery of siRNAs in skin disease therapy DOI
Ana Vitória Pupo Silvestrini, Milena Finazzi Morais, Bryan Wender Debiasi

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115198 - 115198

Published: Feb. 9, 2024

Language: Английский

Citations

12
Insights into Dermal Permeation of Skin Oil Oxidation Products from Enhanced Sampling Molecular Dynamics Simulation DOI Creative Commons
Rinto Thomas, Praveen Ranganath Prabhakar, Douglas J. Tobias

et al.

The Journal of Physical Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

The oxidation of human sebum, a lipid mixture covering our skin, generates range volatile and semivolatile carbonyl compounds that contribute largely to indoor air pollution in crowded environments. Kinetic models have been developed gain deeper understanding this complex multiphase chemistry, but they rely partially on rough estimates kinetic thermodynamic parameters, especially those describing skin permeation. Here, we employ atomistic molecular dynamics simulations study the translocation selected oil products through model stratum corneum membrane. We find these be nontrivial, requiring extensive sampling with up microsecond simulation times, spite employing enhanced techniques. identify high degree order stochastic, long-lived temporal asymmetries membrane structure as leading causes for slow convergence free energy computations. demonstrate statistical errors due insufficient are substantial propagate permeabilities. These independent technique employed very likely precise model.

Language: Английский

Citations

1
A review of the mechanisms of abnormal ceramide metabolism in type 2 diabetes mellitus, Alzheimer’s disease, and their co-morbidities DOI Creative Commons

Yun Pan,

Jieying Li,

P.T. Lin

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 6, 2024

The global prevalence of type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD) is rapidly increasing, revealing a strong association between these two diseases. Currently, there are no curative medication available for the comorbidity T2DM AD. Ceramides structural components cell membrane lipids act as signal molecules regulating homeostasis. Their synthesis degradation play crucial roles in maintaining metabolic balance vivo , serving important mediators development neurodegenerative disorders. Abnormal ceramide metabolism disrupts intracellular signaling, induces oxidative stress, activates inflammatory factors, impacts glucose lipid homeostasis metabolism-related tissues like liver, skeletal muscle, adipose tissue, driving occurrence progression T2DM. connection changes levels brain, amyloid β accumulation, tau hyper-phosphorylation evident. Additionally, regulates survival apoptosis through related signaling pathways, actively participating Regulatory enzymes, their metabolites, pathways impact core pathological molecular mechanisms shared by AD, such insulin resistance response. Consequently, may become potential therapeutic target intervention paper comprehensively summarizes discusses role its metabolites pathogenesis well latest progress treatment with

Language: Английский

Citations

5
Regenerative Cosmetics: Skin Tissue Engineering for Anti-Aging, Repair, and Hair Restoration DOI Creative Commons
Paula Pleguezuelos-Beltrán,

Sara Herráiz-Gil,

Daniel Martínez‐Moreno

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(4), P. 121 - 121

Published: July 15, 2024

The quest for youthful, healthy skin and full, vibrant hair has long been a driving force in the dermocosmetics field. However, traditional approaches often struggle to address underlying causes of aging, damage, loss. Regenerative cosmetics powered by tissue engineering offer transformative alternative. This review explores emerging field using engineered tissues cosmetic purposes, focusing specifically on their potential anti-aging, repair, restoration applications. We discuss how these technologies aim rejuvenate aging promoting collagen production, reducing wrinkles, improving overall function. Additionally, use wound healing scar reduction is examined, highlighting improve appearance functionality damaged skin. Finally, we advance exciting prospects utilizing techniques regenerate follicles, potentially offering solutions loss denser growth.

Language: Английский

Citations

5
Integrating multi‐omics approaches in deciphering atopic dermatitis pathogenesis and future therapeutic directions DOI Open Access
Saeko Nakajima, Satoshi Nakamizo, Takashi Nomura

et al.

Allergy, Journal Year: 2024, Volume and Issue: 79(9), P. 2366 - 2379

Published: June 4, 2024

Atopic dermatitis (AD), a complex and heterogeneous chronic inflammatory skin disorder, manifests in spectrum of clinical subtypes. The application genomics has elucidated the role genetic variations predisposing individuals to AD. Transcriptomics, analyzing gene expression alterations, sheds light on molecular underpinnings Proteomics explores involvement proteins AD pathophysiology, while epigenomics examines impact environmental factors expression. Lipidomics, which investigates lipid profiles, enhances our understanding barrier functionalities their perturbations This review synthesizes insights from these omics approaches, highlighting collective importance unraveling intricate pathogenesis culminates by projecting future trajectories research, particularly promise multi-omics forging personalized medicine novel therapeutic interventions. Such an integrated strategy is poised transform comprehension management, steering towards more precise efficacious treatment modalities.

Language: Английский

Citations

4
Bioactive lipids in the skin barrier mediate its functionality in health and disease DOI Creative Commons
Anna Nicolaou, Alexandra C. Kendall

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 260, P. 108681 - 108681

Published: June 17, 2024

Our skin protects us from external threats including ultraviolet radiation, pathogens and chemicals, prevents excessive trans-epidermal water loss. These varied activities are reliant on a vast array of lipids, many which unique to skin, that support physical, microbiological immunological barriers. The cutaneous physical barrier is dependent specific lipid matrix surrounds terminally-differentiated keratinocytes in the stratum corneum. Sebum- keratinocyte-derived lipids cover skin's surface regulate microbiota. Meanwhile, signal between resident infiltrating immune cells, driving inflammation its resolution response other threats. Lipids particular importance include ceramides, crucial for corneum formation therefore functionality, fatty acids, contribute acidic pH microbiota, as well matrix, bioactive metabolites these involved cell signalling, inflammation, numerous processes. diverse complex maintain homeostasis healthy implicated diseases, unrelated systemic conditions with manifestations, processes such ageing. also gut-skin axis, signalling two sites. Therefore, provide valuable resource exploration processes, local disease development progression, accessible biomarker discovery disease, an opportunity fully understand relationship host Investigation could diagnostic prognostic biomarkers, help identify new targets interventions. Development improvement existing vitro silico approaches explore lipidome, advances lipidomics technologies, will facilitate ongoing progress research.

Language: Английский

Citations

4
Unlocking the role of Herbal Cosmeceutical in Anti-ageing and Skin Ageing Associated Diseases DOI
Prashant Kumar, Anurag Verma, Sumel Ashique

et al.

Cutaneous and Ocular Toxicology, Journal Year: 2024, Volume and Issue: 43(3), P. 211 - 226

Published: July 2, 2024

The process of skin ageing is a natural biological phenomenon characterised by the emergence wrinkles, age spots, sagging skin, and dryness over time. increasing significance in physical attractiveness has heightened skincare concerns. Anti-ageing cosmetics play pivotal role nurturing enhancing its quality, promoting overall health. Today, have evolved beyond mere aesthetics are now integral to individual wellness. contemporary quest for perpetual youth intensified, prompting deeper exploration into process. This comprehensive delves various elements involved ageing, encompassing cells such as stem endothelial cells, blood vessels, soft tissues, signalling pathways. molecular basis including biochemical factors like reactive oxygen species, damaged DNA, free radicals, ions, proteins (mRNA), scrutinised alongside relevant animal models. article critically analyzes outcomes utilising herbal components, emphasising their advantageous anti-ageing properties. contributing mechanistic perspectives, management approaches involving cosmeceutical, associated complications (especially cardiovascular diseases, Parkinson's, Alzheimer's, etc.) succinctly addressed. In addition, manuscript further summarises recent patented innovations toxicity cosmeceuticals disorders. Despite progress, research imperative unlock full potential components agents.

Language: Английский

Citations

4
Establishing a General Atomistic Model for the Stratum Corneum Lipid Matrix Based on Experimental Data for Skin Permeation Studies DOI Open Access
Navaneethan Radhakrishnan, Sunil C. Kaul, Renu Wadhwa

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 674 - 674

Published: Jan. 15, 2025

Understanding the permeation of drugs through intercellular lipid matrix stratum corneum layer skin is crucial for effective transdermal delivery. Molecular dynamics simulations can provide molecular insights into process. In this study, we developed a new atomistic model representing multilamellar arrangement lipids in space studies. The was built using ceramides extended conformation as backbone along with free fatty acids and cholesterol. properties equilibrated were agreement neutron scattering data hydration behavior previously reported literature. permeability molecules, such water, benzene estradiol, mechanism action enhancers, eucalyptol limonene, evaluated model. be reliably used studying small molecules gaining mechanistic enhancers.

Language: Английский

Citations

0
Unfolded protein responses: Dynamic machinery in wound healing DOI
Morgan Minjares,

Pattaraporn Thepsuwan,

Kezhong Zhang

et al.

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108798 - 108798

Published: Jan. 1, 2025

Language: Английский

Citations

0
Poly-γ-Glutamic Acid from a Novel Bacillus subtilis Strain: Strengthening the Skin Barrier and Improving Moisture Retention in Keratinocytes and a Reconstructed Skin Model DOI Open Access
Hyun Ju Ko,

SeoA Park,

Eunjin Shin

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 983 - 983

Published: Jan. 24, 2025

A novel Bacillus subtilis HB-31 strain was isolated from Gotjawal Wetland in Jeju Island, Republic of Korea. mucus substance produced by this identified as high-molecular-weight poly-γ-glutamic acid (γ-PGA) using NMR, Fourier transform infrared spectroscopy, and size-exclusion chromatography/multi-angle light scattering analyses. We evaluated whether γ-PGA strengthened the skin barrier keratinocytes a reconstructed model. In keratinocytes, treatment dose-dependently increased mRNA expression markers, including filaggrin, involucrin, loricrin, serine palmitoyl transferase, fatty synthase, 3-hydroxy-3-methylglutaryl coenzyme reductase. also enhanced hyaluronic synthesis upregulating synthase-1, -2, -3 levels promoted aquaporin 3 expression, which is involved hydration. model, topical application 1% elevated CD44, compared to control. These results suggest that newly can be used commercial production system γ-PGA, serve an effective ingredient for strengthening improving moisture retention. Further research needed explore long-term effects on health its treating conditions.

Language: Английский

Citations

0