The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi DOI Creative Commons

Johanna Revol-Cavalier,

Alessandro Quaranta, John W. Newman

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 125(1), P. 1 - 90

Published: Dec. 16, 2024

The octadecanoids are a broad class of lipids consisting the oxygenated products 18-carbon fatty acids. Originally referring to production phytohormone jasmonic acid, octadecanoid pathway has been expanded include all Octadecanoids formed biosynthetically in mammals via cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) activity, as well nonenzymatically by photo- autoxidation mechanisms. While well-known mediators plants, their role regulation mammalian biological processes generally neglected. However, there have significant advancements recognizing importance these compounds involvement mediation inflammation, nociception, cell proliferation, immuno- tissue modulation, coagulation processes, hormone regulation, skin barrier formation. More recently, gut microbiome shown be source biosynthesis, providing additional biosynthetic routes including hydratase activity (e.g., CLA-HY, FA-HY1, FA-HY2). In this review, we summarize current field octadecanoids, propose standardized nomenclature, provide details preparation measurement, phase-I metabolic formation mammals, bacteria, fungi, describe relation pathophysiology potential use biomarkers health disease.

Language: Английский

Oxylipin profiling for clinical research: Current status and future perspectives DOI Creative Commons
Karol Parchem, Sophia Letsiou, Toni Petan

et al.

Progress in Lipid Research, Journal Year: 2024, Volume and Issue: 95, P. 101276 - 101276

Published: April 30, 2024

Oxylipins are potent lipid mediators with increasing interest in clinical research. They usually measured systemic circulation and can provide a wealth of information regarding key biological processes such as inflammation, vascular tone, or blood coagulation. Although procedures still require harmonization to generate comparable oxylipin datasets, performing comprehensive profiling circulating oxylipins large studies is feasible no longer restricted by technical barriers. However, it essential improve facilitate the interpretation complex profiles truly leverage their potential This requires regular updating our knowledge about metabolism mode action oxylipins, consideration all factors that may influence independently studied disease condition. review aims readers updated necessary metabolism, different forms circulation, current limitations deducing cellular effects from vitro bioactivity studies, confounding needed consider for proper profiles.

Language: Английский

Citations

14
Systematic Profile of Oxylipins in Myocardial Infarction by Liquid Chromatography–Tandem Mass Spectrometry DOI Open Access
Xin Tan,

Hui Ni,

Qin Li

et al.

Rapid Communications in Mass Spectrometry, Journal Year: 2025, Volume and Issue: 39(9)

Published: Jan. 30, 2025

ABSTRACT Rationale Oxylipins play an important role in inflammatory processes, accompanying the occurrence of myocardial infarction. Analyzing a wide panel oxylipins derived from more polyunsaturated fatty acids may provide valuable information to elucidate relationships between signaling mediator profile and infarction comprehensively. Methods An ultrahigh‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method for simultaneously measuring 74 50‐μL human samples with 10‐min chromatographic run easy operation has been developed validated. Results Accuracy precision were below 15% relative errors 99% quality control. Recoveries matrix effect considered acceptable. Potential effects different collecting tubes also assessed. We successfully utilized our approach measure plasma obtained 99 healthy individuals 302 patients. Conclusions Profiles discovered potential biomarkers clarified pathological characteristics oxylipin metabolism Our was rapid, accurate, precise, high throughput, low sample volume, operation, suitable large‐scale studies.

Language: Английский

Citations

0
Food oxylipins: Formation, distribution, analysis and implications for health DOI
D. Rajeswara Rao, Shimin Wu

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104968 - 104968

Published: March 1, 2025

Language: Английский

Citations

0
Oxylipins Derived from PUFAs in Cardiometabolic Diseases: Mechanism of Actions and Possible Nutritional Interactions DOI Open Access
Duygu Ağagündüz, Özge Yeşildemir, Emine Koçyiğit

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3812 - 3812

Published: Nov. 7, 2024

Oxylipins are oxidized fatty acids, both saturated and unsaturated, formed through pathways that involve singlet oxygen or dioxygen-mediated oxygenation reactions primarily produced by enzyme families such as cyclooxygenases, lipoxygenases, cytochrome P450. These lipid-based complex bioactive molecules pivotal signal mediators, acting in a hormone-like manner the pathophysiology of numerous diseases, especially cardiometabolic diseases via modulating plenty mechanisms. It has been reported omega-6 omega-3 oxylipins important novel biomarkers diseases. Moreover, collected literature noted diet dietary components, can modulate these oxygenated lipid products since they mainly derived from polyunsaturated acids (PUFAs) linoleic acid α-linolenic elongation desaturation pathways. This comprehensive review aims to examine their correlations how diets oxylipins. Also, some aspects developing new therapeutical utilization detailed this review.

Language: Английский

Citations

1
The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi DOI Creative Commons

Johanna Revol-Cavalier,

Alessandro Quaranta, John W. Newman

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 125(1), P. 1 - 90

Published: Dec. 16, 2024

The octadecanoids are a broad class of lipids consisting the oxygenated products 18-carbon fatty acids. Originally referring to production phytohormone jasmonic acid, octadecanoid pathway has been expanded include all Octadecanoids formed biosynthetically in mammals via cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) activity, as well nonenzymatically by photo- autoxidation mechanisms. While well-known mediators plants, their role regulation mammalian biological processes generally neglected. However, there have significant advancements recognizing importance these compounds involvement mediation inflammation, nociception, cell proliferation, immuno- tissue modulation, coagulation processes, hormone regulation, skin barrier formation. More recently, gut microbiome shown be source biosynthesis, providing additional biosynthetic routes including hydratase activity (e.g., CLA-HY, FA-HY1, FA-HY2). In this review, we summarize current field octadecanoids, propose standardized nomenclature, provide details preparation measurement, phase-I metabolic formation mammals, bacteria, fungi, describe relation pathophysiology potential use biomarkers health disease.

Language: Английский

Citations

1