Nutrition Bulletin,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 10, 2024
There
is
growing
interest
in
the
role
of
oxylipins
pathophysiology
several
diseases.
This
accompanied
by
a
limited
but
evolving
evidence
base
describing
augmented
oxylipin
concentrations
range
complications
including
cardiovascular
disease,
obesity,
liver
disease
and
neurological
disorders.
Despite
this,
literature
profiles
blood
multiple
organs
inconsistent
mechanisms
which
these
are
altered,
relationships
between
localised
tissue
circulating
poorly
understood.
Inflammation
immune
response
associated
with
requires
communication
across
physiological
systems.
For
example,
inflammation
comorbidities
obesity
extend
beyond
adipose
affect
vascular,
hepatobiliary
digestive
systems
amongst
others.
Communication
implicated
progression
as
well
maintenance
homeostasis.
emerging
for
mechanism
organ
crosstalk
orchestrating
system
responses
Herein,
we
review
to
support
describe
via
cardiosplenic
gut-link
axis.
In
addition,
regulation,
gut
microbiome
modification
using
nutritional
intervention.
Finally,
future
perspectives
addressing
challenges
measurement
interpretation
research
focus
on
host
genome
modifier
dietary
lipid
npj Biofilms and Microbiomes,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Jan. 13, 2025
Sebaceous
free
fatty
acids
are
metabolized
by
multiple
skin
microbes
into
bioactive
lipid
mediators
termed
oxylipins.
This
study
investigated
correlations
between
oxylipins
and
on
the
superficial
of
pre-pubescent
children
(N
=
36)
adults
100),
including
pre-
25)
post-menopausal
females
25).
Lipidomics
metagenomics
revealed
that
Malassezia
restricta
positively
correlated
with
oxylipin
9,10-DiHOME
adult
negatively
its
precursor,
9,10-EpOME,
skin.
Co-culturing
keratinocytes
demonstrated
a
link
pro-inflammatory
cytokines
IL-1β
IL-6
production.
We
also
observed
strong
other
microbial
taxa,
highlighting
life
stage
differences
in
sebum
production
community
composition.
Our
findings
imply
complex
host-microbe
communication
system
mediated
metabolism
occurring
human
skin,
warranting
further
research
role
health
disease
paving
way
towards
novel
therapeutic
targets
treatments.
Consumer
product
chemicals
pose
an
environmental
risk
to
public
health.
Exposure
during
pregnancy
consumer
chemicals,
particularly
phthalates
and
phenols,
may
increase
the
susceptibility
disorders
by
dysregulating
inflammation
oxidative
stress.
However,
existing
studies
rely
on
downstream
nonmodifiable
markers
of
these
processes.
Oxylipins
are
oxidized
lipids
that
act
as
key
upstream
drivers
Importantly,
oxylipins
responsive
therapeutic
interventions
thus
potentially
modifiable.
Using
recent
advances
in
lipidomics
statistical
approaches
address
both
individual
chemical
biomarkers
their
mixtures,
we
determined
associations
between
early
exposure
a
large
prospective
cohort.
Overall,
our
results
revealed
among
produced
across
several
biosynthetic
pathways,
suggesting
pattern
indicative
dysregulated
elevated
levels
Phthalate
metabolites
were
primary
associations,
for
low
molecular
weight
phthalates,
often
used
personal
care
products.
found
similar
biomarker
phthalate
replacement
is
increasingly
Our
study
provides
observational
evidence
specific
physiological
pathways
be
including
legacy
replacements.
Molbank,
Journal Year:
2025,
Volume and Issue:
2025(1), P. M1978 - M1978
Published: March 4, 2025
A
new
oxylipin
(1)
was
isolated
from
cyanobacteria
collected
at
Tokyo
Bay,
Japan.
The
structure
of
1
elucidated
based
on
spectroscopic
data
including
1D
and
2D
NMR,
as
well
high-resolution
mass
spectrometry.
to
be
(S)-2-hydroxy-3-(((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)propyl
(E)-8-hydroperoxyhexadec-6-enoate.
Brain Sciences,
Journal Year:
2025,
Volume and Issue:
15(3), P. 293 - 293
Published: March 11, 2025
Background:
Astrocytes
play
a
key
role
in
the
inflammatory
process
accompanying
various
neurological
diseases.
Extracellular
ATP
accompanies
processes
brain,
but
its
effect
on
lipid
mediators
(oxylipins)
astrocytes
remains
elusive.
Metformin
is
hypoglycemic
drug
with
an
anti-inflammatory
that
has
been
actively
investigated
context
of
therapy
for
neuroinflammation,
mechanisms
action
are
not
fully
elucidated.
Therefore,
we
aimed
to
characterize
effects
markers
and
oxylipin
profiles;
determine
dependence
these
adaptation
high
glucose
levels;
evaluate
possibility
modulating
using
metformin.
Methods:
We
estimated
ATP-mediated
response
primary
rat
cultured
at
normal
(NG,
5
mM)
(HG,
22.5
concentrations
48
h
before
stimulation.
Cell
responses
were
assessed
by
monitoring
changes
expression
(TNFα,
IL-6,
IL-10,
IL-1β,
iNOS,
COX-2)
synthesis
oxylipins
(41
compounds),
assayed
ultra-high-performance
liquid
chromatography
tandem
mass
spectrometry
(UPLC-MS/MS).
Intracellular
pathways
analyzing
phosphorylation
p38;
ERK
MAPK;
transcription
factors
STAT3
NF-κB;
enzymes
mediating
synthesis,
COX-1
cPLA2.
Results:
The
stimulation
cells
does
affect
pro-inflammatory
markers,
increases
activities
p38
MAPKs,
activates
shifting
profiles
toward
increase
compounds
(PGD2,
PGA2,
12-HHT,
18-HEPE).
reduced
HG
astrocytes.
potentiated
ATP-induced
(11-HETE,
PGD2,
15-HETE,
13-HDoHE,
15-HETrE),
which
was
predominantly
evident
NG
cells.
Conclusions:
Our
data
provide
new
evidence
showing
induces
release
oxylipins,
metformin
enhances
effects.
These
results
should
be
considered
development
therapeutic
approaches
astrocyte
function
pathologies.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7827 - 7827
Published: July 17, 2024
Oxidative
stress
has
been
known
about
in
biological
sciences
for
several
decades;
however,
the
understanding
of
this
concept
evolved
greatly
since
its
foundation.
Over
past
years,
reactive
oxygen
species,
once
viewed
as
solely
deleterious,
have
become
recognized
intrinsic
components
life.
In
contrast,
antioxidants,
initially
believed
to
be
cure-all
remedies,
failed
prove
their
efficacy
clinical
trials.
Fortunately,
research
on
health-promoting
properties
antioxidants
ongoing.
Subsequent
years
showed
that
former
assumption
all
acted
similarly
was
oversimplified.
Redox-active
compounds
differ
chemical
structures,
electrochemical
properties,
mechanisms
action,
and
bioavailability;
therefore,
protecting
against
oxidative
also
varies.
review,
we
discuss
changing
perception
sources,
emphasizing
everyday-life
exposures,
particularly
those
dietary
origin.
Finally,
posit
a
better
physicochemical
outcomes
is
crucial
fully
utilize
beneficial
impact
health.
