Studies on lactose utilization by the microalga Graesiella emersonii in the 3N-BBM-V model medium

European Journal of Phycology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: March 21, 2025

Language: Английский

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Polyunsaturated Fatty Acids Improved Long Term Prognosis by Reducing Oxidative Stress, Inflammation, and Endothelial Dysfunction in Acute Coronary Syndromes

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(4), P. 154 - 154

Published: April 1, 2025

Background: Oxidative stress, inflammation, and endothelial dysfunction are important processes in the progression of atherosclerosis occurrence acute coronary syndromes (ACSs). Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) present marine organisms have capacity to reduce all these and, at same time, emergence ACSs. Aim: To evaluate role PUFAs therapy on parameters oxidative inflammatory syndrome, dysfunction, long-term prognosis syndromes. Methods: One thousand one hundred forty patients were admitted Clinic County Emergency Hospital Brasov with ACS enrolled a prospective study. The study was divided into four groups related type treatment added optimal medical (OMT). effect associated OMT determined by measuring dynamics following parameters: (a) stress—total antioxidant status (TAS), oxidated low density lipoprotein cholesterol antibodies (Ab anti-ox-LDL), IgG anti-Myeloperoxidase (IgG Ab anti-MPO); (b) syndrome—C-reactive protein fibrinogen; (c) dysfunction—flow mediated dilation (FMD) von Willebrand factor (vWf) activity, from baseline 6 months follow-up. Clinical events followed 5 years cardiovascular sudden death, Non-ST ST segment elevation ACS, stent thrombosis restenosis, stroke, readmission hospital for heart failure. Results: In groups, significantly decreased Regarding clinical events, significant reduction risk death incidence in-stent failure, observed PUFA-treated comparison control groups. Conclusions: syndromes, resulted decrease also improvement prognosis.

Language: Английский

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The Omega-3 Index in Military Personnel: A Systematic Review

Military Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

ABSTRACT Introduction Long-chain n-3 polyunsaturated fatty acids (LC PUFA), primarily eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), have received considerable interest from the scientific community as a dietary strategy to enhance physical performance, recovery, neuroprotection in addition well-established role of supporting cardiovascular health. Given that military personnel are routinely subjected psychologically physiologically (e.g., cardiovascular, musculoskeletal) stressful environments, LC PUFA intake may represent simple, yet meaningful, nutritional intervention support Warfighter health fitness. Dietary EPA + DHA, via fish or supplement, can be reliably tracked using omega-3 index (O3i), which is relative amount DHA red blood cells (RBC) expressed percentage total acids. The purpose this systematic review was establish baseline O3i status active duty with intent providing actionable evidence-based nutrition recommendations. Materials Methods Three databases (PubMed, Google Scholar, Omega-3 Clinical Study Database) were searched systematically. A 645 articles screened, 11 studies (13 observations) eligible for inclusion. Non-RBC plasma) converted validated equations. Data reported pooled mean analyzed based on service type Army, Air Force). Results Based composed 3,615 personnel, average 3.18% (95% CI: 3.15, 3.21) ranged 2.47% 4.62%. Most observations an <4% (76.9%). Army (combined), U.S. only, Special Forces had <4%, whereas Austrian Force between 4% 5%. Conclusions Military without exception, exhibit suboptimal O3i. Achieving optimal low cost, modifiable risk factor used conjunction traditional medicine appropriate training mission performance personnel. what we know about PUFAs present it paramount Defense organizations acknowledge evidence implement policies strategies promote change. CLINICAL TRIAL REGISTRATION None, but registration (PROSPERO): CRD42023410361

Language: Английский

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Factors Influencing Omega‐3 Knowledge and Consumption Among Saudi Adults: A Cross‐Sectional Study

Advances in Public Health, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Low consumption of omega‐3 polyunsaturated fatty acids (PUFAs) is a significant dietary risk factor for mortality, ranking sixth globally and fourth in Middle Eastern countries. This study was to evaluate Saudi adults’ knowledge awareness omega‐3, identify associated factors. Methods: cross‐sectional survey involved 477 adults, 59% whom were female. An online semistructured questionnaire developed assess participants’ consumption. The consisted three parts: demographical information, 14 questions about their main food sources frequency content validated piloted, demonstrating acceptable internal consistency with Cronbach’s alpha 0.80. Results: average score 7.5 ± 2.9 all participants. Females had significantly higher than males (mean 7.9 2.6, 6.9 3.4, respectively) mean difference 0.70 (95% CI: 0.18, 1.23; p = 0.008). Using regression model, negative association found between BMI category waist circumference, scores ( 0.004, P 0.048, respectively). Conversely, education, family monthly income, physical activity positively < 0.001, 0.011, 0.007). Omega‐3 supplement consumers compared nonconsumers at (−1.76; 95% −2.31, −1.22; 0.001). oily fish intermediate groups consumed less once/month, only 14% the sample meeting recommended intake fish. Barriers affecting “lack accessibility,” “cost,” “dislike taste or smell fish.” Conclusion: findings this highlight need develop culture‐specific campaigns on particularly regarding marine sources. also provides insight into barriers causing low that addressing.

Language: Английский

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Enhanced Absorption of Omega-3 Fatty Acids from a Novel Krill Oil-Derived Phospholipid Formulation Compared to Fish Oil Ethyl Esters: A Randomized, Two-Way Crossover Pharmacokinetic Study

PharmaNutrition, Journal Year: 2024, Volume and Issue: 30, P. 100417 - 100417

Published: Nov. 2, 2024

Language: Английский

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Omega-3 fatty acid regulation of lipoprotein lipase and FAT/CD36 and its impact on white adipose tissue lipid uptake

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 20, 2024

Lipid uptake by white adipose tissue (WAT) is critically important for storage of excess energy and to protect peripheral tissues from ectopic lipid deposition. When WAT becomes dysfunctional (i.e., with obesity), it characterized impaired increased lipolysis which, together, promote whole-body dyslipidemia. Omega-3 polyunsaturated fatty acids (N-3 PUFA) are widely studied their triacylglycerol (TAG)-lowering properties cardiometabolic health benefits. One potential mechanism underlying these benefits the modification uptake; however, there gaps in our understanding regarding specific mechanisms which N-3 PUFA function. Evidence date suggests that TAG clearance increasing lipoprotein lipase (LPL) activity abundance acid transporters. Specifically, have been shown increase LPL through gene transcription modifications endogenously produced regulators such as apolipoprotein C-II/III angiopoietin-like proteins. This review presents discusses available vitro vivo research provide a comprehensive overview regulation healthy obese contexts. Additionally, we highlight areas where more necessary better understand contribution relation TAG-lowering associated PUFA.

Language: Английский

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Fads2 knockout mice reveal that ALA prevention of hepatic steatosis is dependent on delta-6 desaturase activity

Journal of Lipid Research, Journal Year: 2024, Volume and Issue: unknown, P. 100642 - 100642

Published: Sept. 1, 2024

Language: Английский

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Thraustochytrids and Algae as Sustainable Sources of Long-Chain Omega-3 Fatty Acids for Aquafeeds

Sustainability, Journal Year: 2024, Volume and Issue: 16(21), P. 9142 - 9142

Published: Oct. 22, 2024

There is limited ability to biosynthesize long-chain omega-3 fatty acids such as EPA and DHA in food webs leading humans. Seafood the key source of ω3 LC-PUFA, with aquaculture expected meet rising global demand; however, marine fish have a high dietary requirement for themselves. This was traditionally met using unsustainable oil meal, but supply environmental concerns dictated research on replacements. Among industrial sources DHA, microalgae especially thraustochytrids stand out resources concentrations. Although unicellular, are not they photosynthetic instead microheterotrophs. removes light facilitates yields monoculture production single-cell oils. The availability, concentrations, usually one or other essential acid permits calibration dose, which useful their effects mainly been considered together medical research. different cell function precursors bioactive compounds. Using thraustochytrids, microalgae, heterotrophic dinoflagellates, importance has investigated. optimizing growth early life stages scallops finfish preferentially incorporated into membrane phospholipids. microheterotrophs can contribute treatment wastewater waste gas, further enhancing sustainability reducing costs aquaculture.

Language: Английский

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Recent studies confirm the utility of the omega-3 index

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

The Omega-3 Index (O3I) was proposed 20 years ago as not only a marker of body omega-3 fatty acid status, but more importantly, risk factor for fatal coronary heart disease. purpose this review is to document the continued and growing use metric in nutrition research.

Language: Английский

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Omega-3 Fatty Acids and Muscle Strength—Current State of Knowledge and Future Perspectives

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4075 - 4075

Published: Nov. 27, 2024

Omega-3 polyunsaturated fatty acids (n-3 PUFAs), specifically the most biologically active (eicosapentaenoic acid (EPA) and docosahexaenoic (DHA)), have well-documented health-promoting effects, including, but not limited to, controlling inflammatory processes in human body supporting cardiovascular cognitive health visual processes. There is also some evidence pointing to potential of EPA DHA preserve and/or enhance muscle strength. Muscle strength plays a crucial role preventing age-related decline skeletal mass function subsequent impaired functionality daily lives elderly. It has significant physical performance by aiding effectiveness training elements, such as vertical jumps, sprinting, changes direction, rate force development, anaerobic conditioning. Previous studies indicated that supplementation with n-3 PUFAs may small effect on preserving increasing both healthy adults However, number published this topic limited. The goal narrative review summarize effects identify limitations previous that, if addressed, will help confirm or exclude beneficial humans.

Language: Английский

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