Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 29, 2024
Osteoarthritis
(OA)
is
the
most
prevalent
cartilage
degenerative
and
low-grade
inflammatory
disease
of
whole
joint.
However,
there
are
currently
no
FDA-approved
drugs
or
global
regulatory
agency-approved
treatments
OA
modification.
Therefore,
it’s
essential
to
explore
novel
effective
therapeutic
strategies
for
OA.
In
our
study,
we
investigated
effects
AFK-PD,
a
pyridone
agent,
on
development
induced
by
destabilization
medial
meniscus
(DMM)
in
vivo
,
its
impact
function
chondrocytes
treated
with
IL-1β
vitro
.
Our
results
demonstrated
AFK-PD
alleviated
progression
through
inhibiting
degeneration,
articular
inflammation
osteophyte
formation.
Notably,
inhibited
chondrocyte
synovial
macrophage
M1
polarization,
leading
attenuation
inflammation.
Additionally,
promoted
anabolism
while
mitigating
catabolism
apoptosis,
effectively
degeneration.
Mechanistically,
suppressed
expression
key
signaling
molecules
involved
MAPK
pathway,
such
as
p-ERK1/2
p-JNK,
well
NF-κB
molecule
p-p65,
IL-1β-induced
chondrocytes.
These
findings
suggest
ameliorates
protecting
functions
macrophages.
Overall,
study
highlights
promising
candidate
treatment
Frontiers in Physiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 23, 2025
Introduction
Chronic
injury
to
the
rectus
femoris
muscle
induces
and
exacerbates
progression
of
knee
osteoarthritis
(KOA).
However,
lesion
characteristics
in
KOA
at
different
stages
have
not
been
fully
characterized.
The
aim
this
study
was
analyze
pattern
investigate
mechanism
by
which
ultrasound-guided
acupotomy
operations
can
prevent
control
KOA.
Methods
Early,
middle,
late-stage
rabbit
models
were
constructed
using
modified
Videman
method.
Ultrasonography
used
record
elastic
modulus
cross-sectional
area
muscle,
morphology
observe
ultramicroscopic
changes
assess
degree
fibrosis.
Additionally,
performed
on
model
KOA,
alterations
key
molecular
markers
fibrosis
determined
Western
Blot
qPCR
methods.
Results
As
disease
progressed,
rabbits
gradually
increased,
decreased,
increased.
In
contrast,
improved
after
intervention.
Conclusion
These
findings
highlight
gradual
increase
elasticity,
decrease
area,
increased
as
progressed.
Ultrasoundguided
shown
a
protective
effect
cartilage
delay
ameliorating
pathological
muscle.
may
involve
reducing
chronic
protecting
joint
homeostasis
attenuating
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Abstract
Osteoarthritis
(OA)
is
a
degenerative
disease
which
places
an
enormous
burden
on
society,
effective
treatments
are
still
limited.
As
non‐invasive
and
safe
physical
therapy,
low‐intensity
pulsed
ultrasound
(LIPUS)
can
alleviate
OA
progression,
but
the
underlying
mechanism
not
fully
understood,
especially
mechanical
transduction
between
LIPUS
organism.
In
this
pioneering
study,
biomechanical
effects
of
living
mice
chondrocytes
body
zebrafish
investigate
by
using
fluorescence
imaging
technology,
to
dynamically
“visualize”
its
invisible
stimuli
in
form
calcium
oscillations.
It
also
confirmed
that
maintains
cartilage
homeostasis
promoting
chondrocyte
autophagy
calcium‐dependent
manner.
addition,
ion
channels
screened
scRNA‐seq
confirm
mechanosensitive
channel
transient
receptor
potential
vanilloid
4
(TRPV4)
mediated
biological
chondrocytes.
Finally,
it
found
combination
pharmacologically
induced
LIPUS‐induced
Ca
2+
influx
enhances
cartilage‐protective
effect
LIPUS,
may
provide
new
insights
for
optimizing
treatment
OA.
Bone and Joint Research,
Journal Year:
2025,
Volume and Issue:
14(3), P. 199 - 207
Published: March 5, 2025
Osteoarthritis
(OA)
is
a
highly
prevalent
and
disabling
disease
with
an
unmet
therapeutic
need.
The
characteristic
cartilage
loss
alteration
of
other
joint
structures
result
from
complex
interaction
multiple
risk
factors,
mechanical
overload
consistently
playing
central
role.
This
generates
inflammatory
response
in
the
due
to
activation
innate
immune
chondrocytes,
which
occurs
through
various
cellular
mechanisms.
Moreover,
factors
associated
obesity,
being
overweight,
metabolic
syndrome
enhance
both
locally
systemically.
OA
only
cells
present
articular
cartilage,
are
therefore
inflamed
initiate
anabolic
process
attempt
repair
damaged
tissue,
ultimately
results
aberrant
dysfunctional
process.
Under
these
circumstances,
where
continues
be
subjected
chronic
stress,
proposing
treatment
that
stimulates
chondrocytes'
restore
tissue
structure
does
not
appear
target
high
likelihood
success.
In
fact,
drugs
proposed
for
have
yet
demonstrate
efficacy.
By
contrast,
strategies
focused
on
pharmacologically
managing
component,
at
systemic
levels,
shown
promise.
Therefore,
prioritizing
control
pro-inflammatory
pathways
presents
most
viable
promising
strategy
effective
management
OA.
As
research
continues,
this
approach
may
offer
best
opportunity
alleviate
burden
incapacitating
disease.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 2896 - 2896
Published: March 22, 2025
Links
between
cathepsin
K
and
the
pathophysiology
of
osteoarthritis
(OA)
can
be
established,
not
least
because
overabundance
in
serum
OA
patients
upregulation
degraded
cartilage
animal
models
OA.
Chondrocytes,
chondroclasts,
or
osteoclasts
contribute
to
accumulated
at
diseased
osteochondral
junction.
After
a
general
presentation
physiology,
as
well
its
degradation
processes,
we
describe
function
effect
on
via
type
II
collagen
cleavage.
An
overview
most
promising
inhibitors
is
then
presented,
together
with
their
vitro
effects.
Although
intensive
research
initially
focused
bone
resorption,
there
growing
interest
potential
these
drugs
prevent
degradation.
In
this
review,
summarize
pre-clinical
clinical
trials
that
support
use
treatment
To
date,
no
molecules
are
commercially
available,
although
few
have
undergone
trials,
but
believe
development
could
broaden
therapeutic
arsenal
for
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: May 6, 2025
Abstract
Intervertebral
disc
(IVD)
degeneration
is
the
leading
cause
of
low
back
pain
in
young
adults,
and
cartilaginous
endplate
(CEP)
likely
to
play
a
key
role
early
IVD
degeneration.
To
elucidate
effects
pro-inflammatory
cytokines
on
mechanobiology
CEP,
human
CEP
cells
were
seeded
into
2%
agarose,
dynamically
compressed
up
7%,
stimulated
with
tumor
necrosis
factor
(TNF).
It
was
hypothesized
that
dynamic
compression
would
be
sufficient
induce
anabolism,
while
stimulation
TNF
catabolism.
catabolic,
time-dependent
response
through
downregulation
anabolic
gene
expression
increased
secretion
proteins
associated
herniated
discs,
bacteria
inhibition,
pain.
However,
7%
strain
or
scaffold
material,
may
not
lead
full
activation
integrins
pathways,
demonstrated
part
unchanged
integrin
subunits
α
5
β
1
.
Experimental Gerontology,
Journal Year:
2024,
Volume and Issue:
197, P. 112611 - 112611
Published: Oct. 21, 2024
Sarcopenic
obesity
(SO)
and
osteoarthritis
(OA)
are
highly
prevalent
musculoskeletal
conditions
that
significantly
impair
health-related
quality
of
life.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(19), P. 10647 - 10647
Published: Oct. 3, 2024
In
the
past
30
years,
number
of
years
lived
with
disability
due
to
osteoarthritis
(OA)
has
doubled,
making
it
an
increasing
global
health
burden.
To
address
this
issue,
interventions
that
inhibit
progressive
pathology
driven
by
age-related
low-grade
inflammation,
primary
mechanism
OA,
are
being
actively
pursued.
Recent
investigations
have
focused
on
modulating
inflammatory
disease
as
a
therapeutic
target.
However,
no
agent
successfully
halted
disease’s
progression
or
reversed
its
irreversible
course.
Reynoutria
japonica
Houtt.
(RJ),
promising
East
Asian
herbal
medicine,
been
utilized
for
several
diseases
potent
anti-inflammatory
activity.
This
study
aims
determine
RJ’s
capacity
OA
symptoms
and
associated
exploring
potential
further
development.
vivo
in
vitro
experiments
demonstrated
anti-OA
activity
modulation
multifaceted
targets.
RJ
significantly
inhibited
pain,
gait
deterioration,
cartilage
destruction
monosodium
iodoacetate-induced
rat
model,
analgesic
effect
confirmed
acetic
acid-induced
writhing
model.
exhibited
consistent
against
multiple
targets
serum
model
lipopolysaccharide-induced
RAW
264.7
cells.
The
inhibition
cytokines,
including
interleukin-1β,
interleukin-6,
matrix
metalloproteinase-13,
tumor
necrosis
factor-α,
nitric
oxide
synthase
2,
suggests
alleviation
manifestations
relates
These
results
indicate
merits
investigation
disease-modifying
drug
candidate
targeting
OA’s
pathology.
characterize
pharmacological
properties
RJ,
future
studies
expanded
designs
warranted.
