Polymerizable Cholinium-Based Antibiotics for Polymer Carriers: Systems with Combined Load of Cloxacillin and Ampicillin DOI Creative Commons
Shadi Keihankhadiv, Dorota Neugebauer

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5973 - 5973

Published: Dec. 18, 2024

Single and dual-drug delivery systems (DDSs) based on linear choline polymers were designed through the controlled polymerization of a pharmaceutically functionalized monomer, i.e., [2-(methacryloyloxy)ethyl]trimethylammonium, with counterions cloxacillin (TMAMA/CLX), or its copolymerization [2-(methacryloyloxy)ethyl]trimethylammonium ampicillin (TMAMA/AMP), providing antibiotic properties. This strategy was effective in attaining well-defined copolymers 38–93 mol. % TMAMA content, which regulated by initial ratio to methyl methacrylate comonomer. The polymer compositions total monomer conversion (40–75%), resulting variable degree (DPn = 160–300) pharmaceutical anion contents (CLX− 51–80% AMP− 78–87%). In aqueous solution, formed particles sizes ranging between 274 380 nm for CLX− 288–348 CLX−/AMP− systems. vitro drug release, driven exchange anions phosphate ions phosphate-buffered saline (PBS), imitating physiological fluid, demonstrated release efficiencies 58–76% (10.5–13.6 µg/mL) single systems, 91–100% (12.9–15.1 97–100% (21.1–23.3 dual Compared conventional delivering antibiotics without carrier, choline-based DDS attained satisfactory levels loading content (co-)release from carriers, offering promising alternative delivery.

Language: Английский

Adaptive and intelligent polyurethane shape-memory polymers enabling next-generation biomedical platforms DOI Creative Commons

Tomy Muringayil Joseph,

Martin George Thomas, Debarshi Kar Mahapatra

et al.

Case Studies in Chemical and Environmental Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 101165 - 101165

Published: Feb. 1, 2025

Language: Английский

Citations

2
Tailor-Made Polysaccharides for Biomedical Applications DOI Creative Commons
Mohsen Khodadadi Yazdi, Farzad Seidi, Aleksander Hejna

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 4193 - 4230

Published: July 3, 2024

Polysaccharides (PSAs) are carbohydrate-based macromolecules widely used in the biomedical field, either their pure form or blends/nanocomposites with other materials. The relationship between structure, properties, and functions has inspired scientists to design multifunctional PSAs for various applications by incorporating unique molecular structures targeted bulk properties. Multiple strategies, such as conjugation, grafting, cross-linking, functionalization, have been explored control mechanical electrical conductivity, hydrophilicity, degradability, rheological features, stimuli-responsiveness. For instance, custom-made known worldwide tissue engineering, drug/gene delivery, regenerative medicine. Furthermore, remarkable advancements supramolecular engineering chemistry paved way mission-oriented biomaterial synthesis fabrication of customized biomaterials. These materials can synergistically combine benefits biology tackle important questions. Herein, we categorize summarize based on methods, explore main strategies customize chemical structures. We then highlight properties using practical examples. Lastly, thoroughly describe tailor-made PSAs, along current existing challenges potential future directions.

Language: Английский

Citations

9
Protein–Polymer Conjugates as Biocompatible and Recyclable ATRP Catalysts DOI
Lulu Chen, Vasco F. Batista, Henrik Karring

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Atom transfer radical polymerization (ATRP) is a leading method for creating polymers with precise control over molecular weight, yet its reliance on metal catalysts limits application in metal-sensitive and environmental contexts. Addressing these limitations, we have developed recyclable, biocompatible, robust, tunable ATRP catalyst composed of protein-polymer-copper conjugate, synthesized by polymerizing an

Language: Английский

Citations

1
Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing DOI Creative Commons
Neda Rostami, Mohammad Mahmoudi Gomari,

Edris Choupani

et al.

Small Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

The genetic material within cells plays a pivotal role in shaping the structure and function of living organisms. Manipulating an organism's genome to correct inherited abnormalities or introduce new traits holds great promise. Genetic engineering techniques offers promising pathways for precisely altering cellular genetics. Among these methodologies, clustered regularly interspaced short palindromic repeat (CRISPR), honored with 2020 Nobel Prize Chemistry, has garnered significant attention its precision editing genomes. However, CRISPR system faces challenges when applied vivo, including low delivery efficiency, off-target effects, instability. To address challenges, innovative technologies targeted precise have emerged. Engineered carrier platforms represent substantial advancement, improving stability, precision, reducing side effects associated editing. These facilitate efficient local systemic various tissues cells, immune cells. This review explores recent advances, benefits, CRISPR-based delivery. It examines carriers nanocarriers (polymeric, lipid-derived, metallic, bionanoparticles), viral particles, virus-like exosomes, providing insights into their clinical utility future prospects.

Language: Английский

Citations

5
Behind the scenes of green chemistry: Glories and shadows of atom transfer radical polymerization environmental impact (E-factor) DOI
Monika Flejszar, Kinga Ślusarczyk, Faustyna Stopyra

et al.

Polymer, Journal Year: 2024, Volume and Issue: 313, P. 127737 - 127737

Published: Oct. 22, 2024

Language: Английский

Citations

5
Breaking barriers: Smart vaccine platforms for cancer immunomodulation DOI Creative Commons
Mohammad Mahmoudi Gomari,

Taha Ghantabpour,

Nima Pourgholamamiji

et al.

Cancer Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need explore alternative approaches such as vaccines. Leveraging immune system's natural ability target and kill cells holds great therapeutic potential. However, development of vaccines is hindered by several challenges, including low stability, inadequate response activation, immunosuppressive tumor microenvironment, which limit their efficacy. Recent progress various fields, click chemistry, nanotechnology, exosome engineering, neoantigen design, offer innovative solutions these challenges. These achievements have led emergence smart vaccine platforms (SVPs), integrate protective carriers for messenger ribonucleic acid (mRNA) with functionalization strategies optimize targeted delivery. Click chemistry further enhances SVP performance improving encapsulation mRNA antigens facilitating precise delivery review highlights latest developments technologies therapy, exploring both opportunities challenges advancing transformative approaches.

Language: Английский

Citations

0
High efficient mechanically induced atom transfer radical polymerization in aqueous media facilitated by piezoelectric heterostructures DOI

Zhang Junle,

Shuo Xu, Wenjie Zhang

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113837 - 113837

Published: Feb. 1, 2025

Language: Английский

Citations

0
Trending green atom transfer radical polymerization (ATRP)‐modified lactic acid bacteria: application as a bioadsorbent to detoxicate aflatoxin B1 in grains DOI Open Access
Bingchen Wang, Yifan Wang, Lin Chen

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract BACKGROUND To address the severe health risks posed by aflatoxin B 1 (AFB ) in grain, this study employed polydopamine‐based atom transfer radical polymerization (p‐ATRP) and cytochrome C‐catalyzed (c‐ATRP) as cytocompatible modification techniques to coat surface of living Lactobacillus plantarum (LAB) cells with temperature‐sensitive polymer poly( N ‐isopropylacrylamide) (PNIPAAm). RESULTS Two novel bioadsorbents were synthesized. The incorporation PNIPAAm an ‘AFB vacuum cleaner’ layer significantly enhances LAB's adsorption efficiency enables temperature‐controlled desorption. Compared p‐ATRP, c‐ATRP uses C (from membrane protein) a biocatalyst replace necessary copper catalyst eliminating risk toxicity pollution. exceptional AFB capabilities LAB@PNIPAAm can be precisely modeled using Lagergren pseudo‐second‐order Freundlich frameworks, capacity attaining 74.88 ng mL −1 . Furthermore, displays unique temperature‐responsive properties, achieving 78% at 22 °C desorption rate 69% upon temperature elevation 37 °C. It is noteworthy that technology also stress resistance LAB. CONCLUSION These findings offer insights into engineering viable bacterial efficient bioremediation multiple pollutants complex environments. © 2025 Society Chemical Industry.

Language: Английский

Citations

0
Tailoring polymer architectures to drive molecular sieving in protein-polymer hybrids DOI Creative Commons
Kriti Kapil, Hironobu Murata, Lucca Trachsel

et al.

Sustainable Chemistry and Pharmacy, Journal Year: 2025, Volume and Issue: 45, P. 101988 - 101988

Published: March 14, 2025

Language: Английский

Citations

0
Entropy spontaneous ratiometric electrochemical aptasensor based on polymerization and AuNPs signal amplification for Acetamiprid residue analysis DOI Creative Commons
Wei‐Ming Li,

Yuzhen Jia,

Kunyilan Chen

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Acetamiprid (ACE), a next-generation chlorinated neonicotinoid insecticide, has been extensively employed for pest control. However, its excessive residues in food and the environment have raised significant concerns regarding human health. To address need simple, accurate, efficient ACE detection method, this study developed ratiometric electrochemical aptasensor utilizing dual signal amplification strategy involving atom transfer radical polymerization (ATRP) gold nanoparticles (AuNPs). Methylene blue (MB) served as internal reference signal, which was attached to aptamer-DNA1 (dsDNA) through electrostatic adsorption intercalation. Ferrocenyl methyl methacrylate (FMMA) polymerized into long chains via ATRP, generating significantly amplified electrical compared that of monomeric FMMA. AuNPs, known their bioconjugability, were linked DNA2 (AuNPs-DNA2), enhancing loading capacity expanding ATRP reaction sites. In presence ACE, MB decreased while FMMA polymer increased, achieving with limit (LOD) 19.26 pg/mL. This not only enhances selectivity but also mitigates influence background currents, offering novel effective approach real-world sample analysis.

Language: Английский

Citations

0