Antibacterial TiO2 nanoparticles and hydroxyapatite loaded carboxymethyl cellulose bio-nanocomposite scaffold for wound dressing application

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130835 - 130835

Published: April 1, 2025

Language: Английский

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Exudate management nonwovens loaded with Cirsium japonicum DC extract for enhanced hemostatic and wound healing

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114673 - 114673

Published: April 1, 2025

Language: Английский

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Electroactive Electrospun Nanofibrous Scaffolds: Innovative Approaches for Improved Skin Wound Healing

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract The incidence and burden of skin wounds, especially chronic complex have a profound impact on healthcare. Effective wound healing strategies require multidisciplinary approach, advances in materials science bioengineering paved the way for development novel dressing. In this context, electrospun nanofibers can mimic architecture natural extracellular matrix provide new opportunities healing. Inspired by bioelectric phenomena human body, nanofibrous scaffolds with electroactive characteristics are gaining widespread attention gradually emerging. To end, review first summarizes basic process healing, causes current status clinical treatment, highlighting urgency importance dressings. Then, biological effects electric fields, preparation materials, manufacturing techniques (EEN) discussed. latest progress EEN enhancing is systematically reviewed, mainly including treatment monitoring. Finally, scaffold to enhance emphasized, challenges prospects summarized.

Language: Английский

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Ambient Humidity-Dependent Tensile Behavior and Shape Memory Properties of Cinnamoyl Photo-Cross-Linked Poly(2-ethyl-2-oxazoline) Nanofibers

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Electrospun, water-stable nanofiber membranes made from hydrophilic, biocompatible poly(2-ethyl-2-oxazoline) (PEtOx) networks hold significant promise in biomedical applications, particularly wound management. However, their mechanical behavior under varying environmental conditions remains poorly understood. This work provides an in-depth analysis of the tensile properties photo-cross-linked cinnamoyl-modified high-molar-mass PEtOx (PEtOx-Cin) with ambient humidity, assessing practical handling prior to application as dressings, while exploring shape memory basis for potential humidity-actuated closure. Cinnamoyl modification and cross-linking PEtOx-Cin mats significantly improve moisture stability, accelerate sorption, raise glass transition temperature (Tg) through newly formed covalent intermolecular bonds. At higher relative humidity (%RH) 25 65%RH, sorption induces plasticization, shifting Tg below room transforming brittle highly ductile elastomeric. glass-to-rubber enables humidity-stimulated behavior, revealing excellent temporary fixity at low rapid recovery original upon exposure high humidity. The presented findings advance understanding cross-linked membranes, further optimization is needed enhance stability improved handling, they underscore unique next-generation closure dressings.

Language: Английский

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Magnetron Sputtered Carboxymethyl Chitosan Nonwovens as Antibacterial and Exudate Management Dressings

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

ABSTRACT Excessive exudate within the wound can readily result in fluid retention and bacterial infection. Carboxymethyl chitosan (CMCS) nonwoven effectively absorb excess exudate, providing a moist environment for healing. However, CMCS shows poor antimicrobial activity neutral or weakly alkaline environment, absorbent gel property of makes its wet antibacterial modification very difficult. Therefore, Zn‐coated dressings (Zn@CMCS) with management properties were prepared by template‐assisted magnetron sputtering. The Zn 5 @CMCS sputtering time min have excellent air permeability (> 6000 mm/s), high swelling degree (~2500%), superior transition properties. Moreover, exhibits significant against Staphylococcus aureus Escherichia coli . Additionally, benefiting from low coating area (~18%), cytocompatibility. This study provides insights into nonwet

Language: Английский

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Shark skin and mussel-inspired polyurethane hydrogel sponge for wounds with infection and exudate

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137658 - 137658

Published: April 1, 2025

Language: Английский

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A novel multi-functional PVA- alginate hydrogel with dynamic bond crosslinking for infected wound repair

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123636 - 123636

Published: April 1, 2025

Language: Английский

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A novel polyurethane-based silver foam dressing with superior antimicrobial action for management of infected chronic wounds

Biomedical Materials, Journal Year: 2024, Volume and Issue: 20(1), P. 015005 - 015005

Published: Nov. 7, 2024

Wound healing is a complex and dynamic process supported by several cellular events. Around 13 million individuals globally suffer from chronic wounds yearly, for which dressings with excellent antimicrobial activity cell viability (>70%, as per ISO 10993) are needed. Excessive use of silver can cause cytotoxicity has been linked to increasing resistance. In this study, HDI Ag foam was synthesized using safer hexamethylene diisocyanate-based prepolymer (HDI prepolymer) instead commonly used diisocyanates like TDI MDI substantially lower content than that incorporated in other foams. vitro characteristics the were evaluated comparison leading clinically foam-based dressings. All underwent detailed characterization accordance industrially accepted BS EN 13726 standards. The exhibited highest efficiency against

Language: Английский

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Harnessing the Interactions of Wound Exudate Cells with Dressings Biomaterials for the Control and Prognosis of Healing Pathways

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(9), P. 1111 - 1111

Published: Aug. 23, 2024

The global socioeconomic challenge generated by wounds requires an understanding of healing and non-healing pathways in patients. Also, the interactions occurring between wound dressing biomaterials with cells relevant to process have not been sufficiently investigated, thus neglecting role that composition can play healing. Through study six cases acute surgical wounds, present work analyses early (24 h post-surgery) biochemical cellular components (i) Atrauman, a device made knitted woven synthetic polymeric fibre when used as primary dressing, (ii) Melolin, hydrocolloid engineered two layers cellulose non-woven fibres secondary dressing. A pathway towards could be observed those where endoglin-expressing M2 macrophages were retained Atrauman at interface bed. On contrary, Melolin absorbed these cell phenotypes its mesh resulted slower or deteriorating process. data obtained indicate subtraction progenitor may impair analysis retrieved dressings for biomarkers expressed become additional tool determine patient’s prognosis.

Language: Английский

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Antioxidant hydrogel from poly(aspartic acid) and carboxymethylcellulose with quercetin loading as burn wound dressing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137323 - 137323

Published: Nov. 7, 2024

Language: Английский

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