Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 123 - 123

Published: Feb. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Language: Английский

Lyopreservation and Nonionic Decellularization of Human Amnion Scaffolds for Enhancing Regeneration in Chronic Nonhealing Ulcers

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Chronic nonhealing ulcers are responsible for considerable morbidity, given the increasing prevalence of type II diabetes and other comorbid conditions that further worsen healing. This study introduced shelf-stable decellularized lyopreserved human amnion grafts treating difficult-to-heal wounds. The processing approach (comprising a unique combination nonionic surfactants trehalose lyopreservation) applied to develop these bioscaffolds maximized retention sulfated glycosaminoglycans while enhancing both tensile property hydrophilicity. Postprocessing, properties were found be similar skin (5.33 ± 2.45 MPa). Additionally, surface hydrophilicity was increased. It also exhibited optimum moisture transmissibility (evaluated as per BS EN 13726-2 standards), moist wound dressing (1625 375 g/m2/day). Biochemical attributes including total acid-soluble proteins (481.140 14.95 μg/mL) collagen (9.01 0.15 mg/mL) well retained compared fresh membrane. Notably, glycosaminoglycan content processed conserved (there only 21.14% reduction, which substantially lower than reduction achieved by conventionally used biological tissues). regenerative efficacy bioactive scaffolds evaluated through preclinical testing in diabetic rodent model. showed 50% time heal standard care dressings, supported increased vascular endothelial growth factor (VEGF) expression healed tissues. can collectively attributed conservation (GAGs) enhanced scaffold quality, play key roles promoting angiogenesis, tissue regeneration beds. As result, suited variety soft reconstruction applications serve culturing autologous cells, making them versatile tools medicine.

Language: Английский

Foam-Based Drug Delivery Systems for Skin Disorders: A Comprehensive Review

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(4)

Published: April 4, 2025

Language: Английский