Clinical Drug Investigation,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 28, 2025
Abstract
Background
The
coronavirus
disease
2019
(COVID-19)
pandemic
dramatically
impacted
healthcare
systems.
Objective
We
assessed
monthly
unintentional
pediatric
(<
18
years)
exposure
case
rate
trends
involving
selected
nonprescription
cold
and
cough
(CC),
as
well
analgesic
antipyretic
(AA)
drugs,
before
during
the
COVID-19
pandemic,
using
National
Poison
Data
System
(extracted
August
2023).
Methods
included
dextromethorphan,
guaifenesin,
phenylephrine,
pseudoephedrine
CC
acetaminophen,
naproxen,
ibuprofen,
acetylsalicylic
acid
AA
drugs;
statins
served
a
control.
performed
descriptive
analyses
single-product
cases
overall,
by
sex,
age.
interrupted
time
series
(ITS)
analyses,
modeling
associations
between
pandemic’s
immediate
sustained
effects,
adjusting
for
population
seasonality.
Results
Overall,
apart
from
control,
acid,
naproxen
rates
decreased
sharply
at
onset.
In
ITS
most
notably
children
<
6
years
old,
where
unintentional-general
unintentional-therapeutic
error
statistically
significantly
fell
1.8–12.6
per
million
During
gradually
increased
to
pre-pandemic
levels
within
1.5
years.
For
these
rose
0.1–0.6
month
compared
with
levels.
Monthly
patterns
6–12
old
mirrored
those
of
less
pronounced
level
trend
changes.
Conclusions
These
findings
underscore
need
continuously
adapting
public
health
strategies
ensure
drug
safety
prolonged
periods
emergencies.
Cureus,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 25, 2023
To
evaluate
the
accuracy
and
bias
of
ophthalmologist
recommendations
made
by
three
AI
chatbots,
namely
ChatGPT
3.5
(OpenAI,
San
Francisco,
CA,
USA),
Bing
Chat
(Microsoft
Corp.,
Redmond,
WA,
Google
Bard
(Alphabet
Inc.,
Mountain
View,
USA).
This
study
analyzed
chatbot
for
20
most
populous
U.S.
cities.Each
returned
80
total
when
given
prompt
"Find
me
four
good
ophthalmologists
in
(city)."
Characteristics
physicians,
including
specialty,
location,
gender,
practice
type,
fellowship,
were
collected.
A
one-proportion
z-test
was
performed
to
compare
proportion
female
recommended
each
national
average
(27.2%
per
Association
American
Medical
Colleges
(AAMC)).
Pearson's
chi-squared
test
determine
differences
between
chatbots
male
versus
recommendation
accuracy.Female
(1.61%)
(8.0%)
significantly
less
than
27.2%
practicing
(p<0.001,
p<0.01,
respectively).
fewer
(29.5%)
(p<0.722).
(73.8%),
(67.5%),
(62.5%)
gave
high
rates
inaccurate
recommendations.
Compared
academic
(17%),
medicine
or
combined
private
greater
all
chatbots.This
revealed
substantial
inaccuracy
chatbots'
They
struggled
recommend
reliably
accurately,
with
being
physicians
specialties
other
ophthalmology
not
near
desired
city.
showed
a
significant
tendency
against
recommending
ophthalmologists,
favored
medicine.
Current Diabetes Reports,
Journal Year:
2023,
Volume and Issue:
23(8), P. 207 - 216
Published: June 7, 2023
Abstract
Purpose
of
Review
Multiple
studies
report
an
increased
incidence
diabetes
following
SARS-CoV-2
infection.
Given
the
potential
global
burden
diabetes,
understanding
effect
in
epidemiology
is
important.
Our
aim
was
to
review
evidence
pertaining
risk
incident
after
COVID-19
Recent
Findings
Incident
by
approximately
60%
compared
patients
without
Risk
also
non-COVID-19
respiratory
infections,
suggesting
SARS-CoV-2-mediated
mechanisms
rather
than
general
morbidity
illness.
Evidence
mixed
regarding
association
between
infection
and
T1D.
associated
with
elevated
T2D,
but
it
unclear
whether
persistent
over
time
or
differs
severity
time.
Summary
diabetes.
Future
should
evaluate
vaccination,
viral
variant,
patient-
treatment-related
factors
that
influence
risk.
Proceedings of the National Academy of Sciences,
Journal Year:
2024,
Volume and Issue:
121(6)
Published: Feb. 1, 2024
In
the
United
States,
estimates
of
excess
deaths
attributable
to
COVID-19
pandemic
have
consistently
surpassed
reported
death
counts.
Excess
non-COVID-19
natural
causes
may
represent
unrecognized
deaths,
caused
by
health
care
interruptions,
and/or
from
pandemic’s
socioeconomic
impacts.
The
geographic
and
temporal
distribution
these
help
evaluate
which
explanation
is
most
plausible.
We
developed
a
Bayesian
hierarchical
model
produce
monthly
natural-cause
mortality
for
US
counties
over
first
30
mo
pandemic.
From
March
2020
through
August
2022,
1,194,610
occurred
nationally
[90%
PI
(Posterior
Interval):
1,046,000
1,340,204].
A
total
162,886
(90%
PI:
14,276
308,480)
were
not
COVID-19.
Overall,
15.8
every
100
deaths.
This
number
was
greater
in
nonmetropolitan
(36.0
deaths),
West
(Rocky
Mountain
states:
31.6
deaths;
Pacific
25.5
South
(East
Central
26.0
Atlantic
25.0
24.2
deaths).
contrast,
counts
metropolitan
New
England
Middle
states.
Increases
correlated
temporally
with
increases
same
prior
month.
suggests
that
many
during
States
World Journal of Surgery,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
ABSTRACT
Background
Necrotizing
fasciitis
(NF)
is
a
severe
and
rapidly
progressing
soft
tissue
infection
with
high
mortality
rates.
Despite
the
urgency
of
this
condition,
there
limited
research
on
long‐term
NF‐related
trends
in
United
States.
Objective
This
study
aims
to
analyze
adults
aged
25
older
States
from
2003
2020,
focusing
variations
by
sex,
race/ethnicity,
geographic
region.
Methods
deaths
were
identified
using
CDC
WONDER
database
through
ICD‐10
code
M72.6.
Crude
age‐adjusted
rates
(AAMRs)
calculated
across
demographic
groups
regions.
Temporal
assessed
joinpoint
regression,
providing
annual
percent
change
(APC)
Results
From
total
19,158
recorded,
marking
120.6%
increase,
rising
824
1842
2020.
The
overall
AAMR
increased
0.44
per
100,000
0.71
Males
consistently
had
higher
than
females
both
sexes
saw
sharp
rise
after
2015.
By
American
Indian
or
Alaska
Native
populations
exhibited
highest
rates,
followed
Black
African
individuals.
Regional
revealed
that
West
AAMR,
whereas
Northeast
recorded
lowest.
A
significant
was
observed
all
regions
2014.
Additionally,
urban–rural
analysis
indicated
large
central
metropolitan
areas
elevated
smaller
noncore
experienced
sharper
increases.
Conclusions
has
significantly
risen
since
2014,
distinct
disparities
based
race,
Contributing
factors
may
include
chronic
conditions,
healthcare
access
issues,
climate‐related
events.
Public
health
interventions
early
diagnosis,
timely
treatment,
addressing
inequities
are
essential
for
improving
outcomes
(highlighted
shows
corrections).
Cureus,
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 23, 2023
Background
This
study
estimates
the
burden
of
COVID-19
on
mortality
in
Germany.
It
is
expected
that
many
people
have
died
because
new
virus
who
otherwise
would
not
died.
Estimating
pandemic
by
number
officially
reported
COVID-19-related
deaths
has
been
proven
to
be
difficult
due
several
reasons.
Because
this,
a
better
approach,
which
used
studies,
estimate
calculating
excess
for
years.
An
advantage
such
an
approach
additional
negative
impacts
are
covered
as
well,
possible
pandemic-induced
strain
healthcare
system.
Methods
To
calculate
Germany
years
2020
2022,
we
compare
all-cause
(i.e.,
independently
underlying
causes)
with
statistically
deaths.
For
state-of-the-art
method
actuarial
science,
based
population
tables,
life
and
longevity
trends,
from
2022
if
there
had
no
pandemic.
Results
The
results
show
observed
was
close
respect
empirical
standard
deviation;
approximately
4,000
occurred.
By
contrast,
2021,
two
deviations
above
even
more
than
four
times
deviation
2022.
In
total,
year
2021
about
34,000
66,000
deaths,
yielding
cumulated
100,000
both
high
mainly
increase
age
groups
between
15
79
started
accumulate
only
April
onward.
A
similar
pattern
stillbirths
9.4%
second
quarter
19.4%
fourth
compared
previous
Conclusions
These
findings
indicate
something
must
happened
spring
led
sudden
sustained
mortality,
although
effects
during
early
so
far.
Possible
influencing
factors
explored
discussion.
BMC Public Health,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: Sept. 26, 2023
Abstract
Background
Delays
in
health
care
have
been
observed
the
U.S.
during
COVID-19
pandemic;
however,
prevalence
of
inability
to
get
needed
and
potential
disparities
access
yet
be
assessed.
Methods
We
conducted
a
nationally
representative,
online
survey
5,500
American
Indian/Alaska
Native,
Asian,
Black/African
American,
Latino
(English-
Spanish-speaking),
Native
Hawaiian/Pacific
Islander,
White,
multiracial
adults
between
12/2020–2/2021
(baseline)
8/16/2021–9/9/2021
(6-month
follow-up).
Participants
were
asked
“Since
start
pandemic,
was
there
any
time
when
you
did
not
medical
that
needed?”
Those
who
responded
“Yes”
about
type
reason
for
receiving
care.
Poisson
regression
used
estimate
association
sociodemographics
receive
care;
all
analyses
stratified
by
chronic
condition
status.
Chronic
conditions
included:
obstructive
pulmonary
disease
(COPD),
heart
conditions,
2
diabetes,
kidney
or
on
dialysis,
sickle
cell
disease,
cancer,
immunocompromised
state
(weakened
immune
system).
Results
Overall,
20.0%
participants
at
baseline
22.7%
follow-up
reported
getting
The
most
common
reasons
being
unable
included
fear
(baseline:
44.1%;
follow-up:
47.2%)
doctors
canceled
appointment
25.3%;
14.1%).
Routine
59.9%;
62.6%)
management
31.5%;
30.1%)
often
types
delayed
Fair/poor
self-reported
physical
significantly
associated
with
despite
status
(≥
1
condition:
aPR
=
1.36,
95%CI
1.04–1.78);
no
conditions:
1.52,
95%
CI
1.28–1.80).
likelihood
differed
some
instances
race/ethnicity,
age,
insurance
For
example,
uninsured
more
likely
1.76,
1.17–2.66);
1.25,
1.00–1.56).
Conclusions
one
fifth
follow-up.
may
exacerbate
existing
perpetuate
among
vulnerable
populations
received
pandemic.
American Journal of Public Health,
Journal Year:
2024,
Volume and Issue:
114(S1), P. S112 - S123
Published: Jan. 1, 2024
Objectives.
To
provide
initial
findings
from
Community
Engagement
Alliance
(CEAL),
a
multistate
effort
funded
by
the
National
Institutes
of
Health,
to
conduct
urgent
community-engaged
research
and
outreach
focused
on
COVID-19
awareness,
education,
evidence-based
response.
Methods.
We
collected
survey
data
(November
2020–November
2022)
21
CEAL
teams
29
state
regional
sites
spanning
19
US
states,
District
Columbia,
Puerto
Rico,
which
covered
priority
populations
served
trusted
sources
information
about
COVID-19,
including
prevention
behaviors,
vaccination,
clinical
trials.
Results.
A
disproportionate
number
respondents
were
Latino
(45%)
or
Black
(40%).
There
was
considerable
variability
between
regarding
information,
prevention,
vaccination.
For
example,
more
(70%)
reported
health
care
providers
as
source
than
any
other
(ranging
6%
87%
site).
Conclusions.
rapidly
developed
novel
infrastructure
engage
academic,
public
health,
community
organizations
address
COVID-19’s
impacts
underserved
communities.
provides
an
example
how
respond
in
future
emergencies
quickly
promote
trustworthy,
ways
that
advance
equity.
(Am
J
Public
Health.
2024;114(S1):S112–S123.
https://doi.org/10.2105/AJPH.2023.307504
)
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(5), P. 1356 - 1356
Published: Feb. 27, 2024
(1)
Background:
The
impact
of
armed
conflicts
on
public
health
is
undeniable,
with
psychological
stress
emerging
as
a
significant
risk
factor
for
cardiovascular
disease
(CVD).
Nevertheless,
contemporary
data
regarding
the
influence
war
CVD,
and
especially
acute
coronary
syndrome
(ACS),
are
scarce.
Hence,
aim
current
study
was
to
assess
repercussions
admission
prognosis
patients
admitted
tertiary
care
center
intensive
unit
(ICCU).
(2)
Methods:
All
ICCU
during
first
three
months
Israel–Hamas
(2023)
were
included
compared
all
same
period
in
2022.
primary
outcome
in-hospital
mortality.
(3)
Results:
A
total
556
(184
females
[33.1%])
median
age
70
(IQR
59–80)
included.
Of
them,
295
(53%)
war.
Fewer
Arab
more
ST-segment
elevation
myocardial
infraction
(STEMI)
(21.8%
vs.
13.2%,
p
<
0.001,
31.9%
24.1%,
=
0.04,
respectively),
whereas
non-STEMI
(NSTEMI)
frequently
pre-war
year
(19.3%
25.7%,
0.09).
In-hospital
mortality
similar
both
groups
(4.4%
3.4%,
0.71;
HR
1.42;
95%
CI
0.6–3.32,
0.4).
(4)
Conclusions:
During
war,
fewer
STEMI
ICCU.
groups.
BMC Health Services Research,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Jan. 4, 2024
Abstract
Background
The
coronavirus
disease
2019
(COVID-19)
pandemic
has
disrupted
healthcare
systems
throughout
the
world.
Many
patients
faced
delays
and
cancellation
of
care
due
to
scaled
back
services,
mobility
restrictions,
concerns
related
risk
infection.
present
study
aimed
assess
prevalence
factors
associated
with
avoidance
or
delay
medical
COVID-19
in
Armenia.
Methods
We
conducted
a
cross-sectional
telephone
survey
3,483
adults
across
used
stratified
two-stage
cluster
sampling
select
participants
from
different
age
groups
proportionate
their
size
population.
Logistic
regression
analysis
assessed
association
avoidance/delay
routine,
urgent/emergency,
any
care.
Results
mean
sample
was
49.5
(SD
=
14.8),
ranging
18
90.
About
9.9%
respondents
avoided/delayed
type
care;
whereas
5.5%
urgent/emergency
6.6%
routine
In
adjusted
analysis,
female
gender
higher
monthly
expenditures
were
Factors
delay/avoidance
included
perceived
threat
COVID-19.
Younger
age,
gender,
not
being
vaccinated
against
analysis.
Conclusion
Since
avoiding
delaying
might
increase
morbidity
mortality
conditions
COVID-19,
identifying
population
that
are
more
likely
avoid
is
important.
Targeting
such
educational
interventions
focusing
on
risks
using
versus
times
be
crucial.
Ensuring
provision
in-home
services
for
high-risk
help
address
important
needs
during
pandemic.