Cognitive impairment after long COVID-19: current evidence and perspectives

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: July 31, 2023

COVID-19, caused by the SARS-CoV-2 virus, is a respiratory infectious disease. While most patients recover after treatment, there growing evidence that COVID-19 may result in cognitive impairment. Recent studies reveal some individuals experience deficits, such as diminished memory and attention, well sleep disturbances, suggesting could have long-term effects on function. Research indicates contribute to decline damaging crucial brain regions, including hippocampus anterior cingulate cortex. Additionally, identified active neuroinflammation, mitochondrial dysfunction, microglial activation patients, implying these factors be potential mechanisms leading Given findings, possibility of impairment following treatment warrants careful consideration. Large-scale follow-up are needed investigate impact function offer support clinical rehabilitation practices. In-depth neuropathological biological can elucidate precise provide theoretical basis for prevention, intervention research. Considering risks reinfection, it imperative integrate basic research data optimize preservation patients' quality life. This integration will also valuable insights responding similar public health events future. perspective article synthesizes discussing outlining future directions.

Language: Английский

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Incidence of diabetes after SARS-CoV-2 infection in England and the implications of COVID-19 vaccination: a retrospective cohort study of 16 million people

The Lancet Diabetes & Endocrinology, Journal Year: 2024, Volume and Issue: 12(8), P. 558 - 568

Published: July 23, 2024

Some studies have shown that the incidence of type 2 diabetes increases after a diagnosis COVID-19, although evidence is not conclusive. However, effects COVID-19 vaccine on this association, or effect other subtypes, are clear. We aimed to investigate association between and 2, 1, gestational non-specific diabetes, COVID- 19 vaccination, up 52 weeks diagnosis.

Language: Английский

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Demographic Trends and Disparities in Mortality Related to Coexisting Heart Failure and Diabetes Mellitus Among Older Adults in the United States between 1999 and 2020: A Retrospective Population-based Cohort Study from the CDC WONDER Database

International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2024, Volume and Issue: 23, P. 200326 - 200326

Published: Aug. 24, 2024

Heart Failure (HF) and Diabetes Mellitus (DM) often coexist, each condition independently increases the likelihood of developing other. While there has been concern regarding increasing burden disease for both conditions individually over last decade, a comprehensive examination mortality trends demographic regional disparities needs to be thoroughly explored in United States (US).

Language: Английский

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Prevalence and factors associated with severe fatigue 2 years into the COVID-19 pandemic: a cross-sectional population-based study in Geneva, Switzerland

BMJ Open, Journal Year: 2025, Volume and Issue: 15(1), P. e089011 - e089011

Published: Jan. 1, 2025

Objectives This study aims (1) to assess the prevalence of severe fatigue among general population Geneva, 2 years into COVID-19 pandemic and (2) identify non-pandemic factors associated with fatigue. Design Cross-sectional population-based survey conducted in Spring 2022. Setting General adult Switzerland. Participants 6870 participants, randomly selected from population, included Specchio-COVID-19 cohort study, were invited answer an online health survey. Outcome cofactor measure Prevalence was measured by Chalder Fatigue Questionnaire a cut-off score≥4 out 11. We assessed ratios considering sociodemographic factors, behavioural characteristics (body mass index, depression, recent diagnosis chronic disease or allergy, acute event, smoking status, physical activity sleep quality) self-reported infections. Results A total 4040 individuals participated (participation rate 59%, 58% women, mean age 53.2 (SD=14.1 years)). Overall 30.7% (95% CI=29.2%–32.1%). After adjusting for age, sex, educational level pre-existing comorbidities, following fatigue: aged 18–24 (adjusted ratio (aPR)=1.39 (1.10–1.76)) 25–34 (aPR=1.23 (1.05–1.45)), female sex (aPR=1.28 (1.16–1.41)), depression (aPR=2.78 (2.56–3.01)), occurrence events unrelated (aPR=1.51 (1.38–1.65)) infection past 12 months (aPR=1.41 (1.28–1.56)). further adjustment previous associations maintained except young age. Conclusions About one-third Geneva experienced fatigue, pandemic. Heightened adults is partly explained depressive symptoms. Recent substantially regardless severity co-occurrence disorder. Trial registration number CCER project ID 2020-00881.

Language: Английский

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Impact of the COVID-19 Pandemic and Control Measures on Screening and Diagnoses of Type 2 Diabetes in British Columbia

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(4), P. 519 - 519

Published: March 28, 2025

Introduction: In British Columbia (BC), Canada, COVID-19 and associated control measures impacted routine care for patients with diabetes. Some of these may have timely screening diagnosis type 2 We assessed the impact on diabetes in BC. Methods: used data from BC Cohort, which includes healthcare administrative all residents compared (≥40 yrs) (≥18 among adult population during pandemic period (1 April 2020–31 December 2022), 1 January 2016–31 March 2020 as a historical reference period. interrupted time series generalized additive models to evaluate policy diagnoses trends. Results: observed an initial decline mean number screenings diagnoses. third post-policy phase (January 2022–December there was 4.8% (−5.1, 15.4) increase while after reduction diagnoses, we significant 31.6% (17.8, 46.6) phase. Further stratification by age sex showed entire trends driven younger females 56.4% (25.1, 92.9) 58.7% (38.2, 81.3) increment 18–29 40–49 groups, respectively. Conclusions: The reduced followed upward trend later important clinical public health implications. research is needed understand post-pandemic females.

Language: Английский

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Early-childhood body mass index and its association with the COVID-19 pandemic, containment measures and islet autoimmunity in children with increased risk for type 1 diabetes

Diabetologia, Journal Year: 2024, Volume and Issue: 67(4), P. 670 - 678

Published: Jan. 12, 2024

Abstract Aims/hypothesis The aim of this study was to determine whether BMI in early childhood affected by the COVID-19 pandemic and containment measures, it associated with risk for islet autoimmunity. Methods Between February 2018 May 2023, data on autoimmunity were collected from 1050 children enrolled Primary Oral Insulin Trial, aged 4.0 months 5.5 years age. start defined as 18 March 2020, a stringency index used assess measures. Islet either development persistent confirmed multiple autoantibodies, or one more autoantibodies type 1 diabetes. Multivariate linear mixed-effect, logistic regression methods applied effect early-childhood measurements (BMI time-varying variable, at 9 age overweight age), Cox proportional hazard models risk. Results increased ( β = 0.39; 95% CI 0.30, 0.47) 0.44; 0.03, 0.84). During pandemic, higher positively 0.02; 0.00, 0.04 per 10 units increase), 0.13; 0.01, 0.25) 0.23; 0.43). A age-corrected developing up (HR 1.16; 1.01, 1.32 HR 1.68, 1.00, 2.82, respectively). Conclusions/interpretation Early-childhood during influenced level restrictions pandemic. Controlling elevated genetic susceptibility Graphical

Language: Английский

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Long COVID—ACOEM Guidance Statement

Journal of Occupational and Environmental Medicine, Journal Year: 2024, Volume and Issue: 66(4), P. 349 - 357

Published: Feb. 2, 2024

Abstract Persistent symptoms are common after acute COVID-19, often referred to as long COVID. Long COVID may affect the ability perform activities of daily living, including work. occurs more frequently in those with severe COVID-19. This guidance statement reviews pathophysiology COVID-19 and provides pragmatic approaches symptoms, syndromes, conditions occupational setting. Disability laws workers’ compensation also addressed.

Language: Английский

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Risk of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Among Patients with Type 2 Diabetes Mellitus on Anti-Hyperglycemic Medications

Clinical Epidemiology, Journal Year: 2024, Volume and Issue: Volume 16, P. 379 - 393

Published: May 1, 2024

Observed activity of metformin in reducing the risk severe COVID-19 suggests a potential use anti-hyperglycemic prevention post-acute sequelae SARS-CoV-2 infection (PASC). We assessed 3-month and 6-month PASC among patients with type 2 diabetes mellitus (T2DM) comparing users to sulfonylureas (SU) or dipeptidyl peptidase-4 inhibitors (DPP4i) users.

Language: Английский

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The Functions of SARS-CoV-2 Receptors in Diabetes-Related Severe COVID-19

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9635 - 9635

Published: Sept. 5, 2024

Angiotensin-converting enzyme 2 (ACE2) is considered a severe acute respiratory syndrome coronavirus (SARS-CoV-2) receptor of high importance, but due to its non-ubiquitous expression, studies other proteins that may participate in virus internalisation have been undertaken. To date, many alternative receptors discovered. Their functioning provide an explanation for some the events observed COVID-19 cannot be directly explained by model which ACE2 constitutes central point infection. Diabetes mellitus type (T2D) can induce development. Although mechanisms associated with lead increased SARS-CoV-2 virulence diabetes, such as basigin (CD147), glucose-regulated protein 78 kDa (GRP78), cluster differentiation 4 (CD4), transferrin (TfR), integrins α5β1/αvβ3, or co-receptors neuropilin (NRP2), vimentin, and even syalilated gangliosides also responsible worsening course. On hand, others play protective roles. Understanding how diabetes-associated via modification needs further extensive studies.

Language: Английский

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The Roles of Glutathione and Oxidative Stress in Diabetes and COVID-19

Published: July 24, 2024

Evidence suggests that COVID-19 infection increases the risk of type 1 (T1D) and 2 diabetes (T2D). Diabetes, in turn, susceptibility contributes to increased morbidity mortality. Oxidative stress (OxS) has emerged as a common factor driving pathogenesis caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2). The mechanistic links between OxS, T2D, have primarily been studied adults will be summarized this review. However, we suggest studying these interconnections children young is critical since early intervention optimal for improving outcomes. At height pandemic, was leading cause death people, people age group are susceptible elderly. Glutathione (GSH) primary water-soluble intracellular antioxidant can deficient both COVID-19. GSH tripeptide containing cysteine (CYS), glutamic acid (GLU), glycine (GLY). Strategies increase levels may beneficial helping manage COVID-19-induced well diabetes-induced risk. Dietary supplementation with GlyNAC it contains two metabolic precursors, i.e., n-acetyl-l-cysteine (NAC) GLY.

Language: Английский

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