A mesoscale connectome-based model of conscious access in the macaque monkey DOI Creative Commons
Ulysse Klatzmann, Seán Froudist‐Walsh,

Daniel P. Bliss

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Feb. 22, 2022

Abstract A growing body of evidence suggests that conscious perception a sensory stimulus coincides with all-or-none activity across multiple cortical areas, phenomenon called ‘ignition’. In contrast, the same stimulus, when undetected, induces only transient activity. this work, we report large-scale model macaque cortex based on recently quantified structural mesoscopic connectome data. We use to simulate detection task, and demonstrate how dynamical bifurcation mechanism produces ignition-like events in network. The predicts feedforward excitatory transmission is primarily mediated by fast AMPA receptors ensure rapid signal propagation from associative areas. greater proportion inter-areal feedback projections local recurrent excitation depend slow NMDA receptors, ignition distributed frontoparietal Our predicts, counterintuitively, fast-responding areas contain higher ratio compared association show slow, sustained validate prediction using cortex-wide in-vitro receptor autoradiography Finally, can account for various behavioral physiological effects linked consciousness. Together, these findings clarify neurophysiological mechanisms access primate support concept gradients densities along hierarchy contribute cognitive functions.

Language: Английский

A dynamic bifurcation mechanism explains cortex-wide neural correlates of conscious access DOI Creative Commons
Ulysse Klatzmann, Seán Froudist‐Walsh,

Daniel P. Bliss

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(3), P. 115372 - 115372

Published: March 1, 2025

Language: Английский

Citations

1
Three cortical streams for somatosensory information processing DOI Creative Commons
Meiqi Niu, Seán Froudist‐Walsh,

Yujie Hou

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract The somatosensory cortex processes information hierarchically, transforming sensory input into appropriate responses. This hierarchy, in turn, provides a fundamental principle for the organization of anatomical and functional properties across cortex. While local hierarchy has been studied, comprehensive model that fully illustrates transmission fine detail remains lacking. In this study, we examine multimodal connectivity patterns entire macaque by integrating from receptor covariance (RC) structural (SC) or (FC). Our findings not only reveal hierarchical relationships but also propose processing streams. model, area 3bl serves as initial cortical stage signals, projecting to areas 3al, 1, 2. From there, signals follow three major pathways: ventrally SII complex, medially medial SI TSA, posteriorly association parietal lobe. Further analysis shows RC is closely linked SC FC addition displays unique characteristics likely relate modalities. study deepens our understanding brain different modalities links structural, chemoarchitectonic,

Language: Английский

Citations

0
A mesoscale connectome-based model of conscious access in the macaque monkey DOI Creative Commons
Ulysse Klatzmann, Seán Froudist‐Walsh,

Daniel P. Bliss

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Feb. 22, 2022

Abstract A growing body of evidence suggests that conscious perception a sensory stimulus coincides with all-or-none activity across multiple cortical areas, phenomenon called ‘ignition’. In contrast, the same stimulus, when undetected, induces only transient activity. this work, we report large-scale model macaque cortex based on recently quantified structural mesoscopic connectome data. We use to simulate detection task, and demonstrate how dynamical bifurcation mechanism produces ignition-like events in network. The predicts feedforward excitatory transmission is primarily mediated by fast AMPA receptors ensure rapid signal propagation from associative areas. greater proportion inter-areal feedback projections local recurrent excitation depend slow NMDA receptors, ignition distributed frontoparietal Our predicts, counterintuitively, fast-responding areas contain higher ratio compared association show slow, sustained validate prediction using cortex-wide in-vitro receptor autoradiography Finally, can account for various behavioral physiological effects linked consciousness. Together, these findings clarify neurophysiological mechanisms access primate support concept gradients densities along hierarchy contribute cognitive functions.

Language: Английский

Citations

9