Ultrasensitive Nano-Biosensors for Virus Detection DOI

Amany S. Hegazy,

Abdullah M. M. Elbadry,

Fatma E. Sayed

et al.

Published: Oct. 18, 2023

Viruses are among the most contagious infections and main cause of death globally. The lack effective clinical treatments for viruses highlights importance prompt correct diagnosis at earliest signs infection to stop pathogens from spreading quickly. From diagnostics therapies, development a sensitive focused detection system pathogenic viral agents is crucial. However, current traditional methods laborious time-consuming, require expensive equipment, qualified personnel. This clearly confirms need simple method detect virus low cost without sample pre-treatment, in other words: biosensors. A sensor with higher sensitivity selectivity has been developed achieve this goal by utilizing variety characteristics methodologies. Due their speed, cost-effectiveness, accuracy, sensitivity, selectivity, biosensors might be seen as tool improve point-of-care numerous diseases over conventional methods. Additionally, these have successfully applied identify broad range viruses, enabling administration appropriate medication. Diagnostic recently received significant support field nanotechnology thanks creation intelligent, miniature nano-biosensors that improved elevated process new level. challenges future prospects developing such ultrasensitive also taken into account before claiming nano-weapons ideal futuristic gold standard diagnosis. Because portability, toughness, affordability, an diagnostic agent different types viruses.

Language: Английский

Review on Healthcare Biosensing Nanomaterials DOI
Alok Tripathi, José Bonilla‐Cruz

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(7), P. 5042 - 5074

Published: March 31, 2023

Fast technological progress has sped up the growth of telemedicine, mobile e-health services, and healthcare monitoring, which, nowadays, are technologies in high demand medical field analytical sensing. Biosensing device design promoted forefront research topics wherein new sensing have been developed. In this regard, nanomaterials had a crucial role novel biosensors based on emerged as detective tools for several biomolecules. Most remarkably sensitive selective to detect cancer biomarkers, toxins foods, drugs, pathogenic microorganisms, cholesterol, pesticides, nucleic acids, glucose, heavy-metal contaminations, other bioanalytes under different platforms at extraordinarily low concentrations (nanomolar, picomolar, or femtomolar). A comprehensive review used biosensing is offered herein. Specifically, offers point view, highlighting covering exhaustively kinds (<500 nm) human diseases through biosensing. sense, we organize them into organic, inorganic, carbon-based, thus offering guide selecting best nanomaterial specific detection. Further, it provides roadmap real-time utilization commercial scale. Also, addresses some aspects use applications The discussed paper highlights immense potential implement nanocomposites initial examination point-of-care testing.

Language: Английский

Citations

56
A comprehensive review on enzyme-based biosensors: Advanced analysis and emerging applications in nanomaterial-enzyme linkage DOI
Rafael Leandro Fernandes Melo, Francisco Simão Neto, Dayana Nascimento Dari

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130817 - 130817

Published: March 11, 2024

Language: Английский

Citations

22
Innovations in Biosensor Technologies for Healthcare Diagnostics and Therapeutic Drug Monitoring: Applications, Recent Progress, and Future Research Challenges DOI Creative Commons
Mohamed Hemdan, Mohamed A. Ali, Ahmed S. Doghish

et al.

Sensors, Journal Year: 2024, Volume and Issue: 24(16), P. 5143 - 5143

Published: Aug. 8, 2024

This comprehensive review delves into the forefront of biosensor technologies and their critical roles in disease biomarker detection therapeutic drug monitoring. It provides an in-depth analysis various types applications, including enzymatic sensors, immunosensors, DNA elucidating mechanisms specific healthcare applications. The highlights recent innovations such as integrating nanotechnology, developing wearable devices, trends miniaturisation, showcasing transformative potential healthcare. In addition, it addresses significant sensitivity, specificity, reproducibility, data security challenges, proposing strategic solutions to overcome these obstacles. is envisaged that will inform decision-making, drive technological innovation, enhance global outcomes by synthesising multidisciplinary insights.

Language: Английский

Citations

22
Semiconductor Nanomaterials DOI
Monika Chauhan,

Ananya Bhatia,

Diwakar Chauhan

et al.

BENTHAM SCIENCE PUBLISHERS eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 26 - 49

Published: Oct. 6, 2024

The physical and chemical characteristics of semiconductor materials radically alter as their size is shrunk to the nanoscale, giving rise unusual traits because enormous surface area or quantum effect. Despite being at research stage right now, nanomaterials devices hold great promise for use in a variety sectors, including solar cells, nanoscale electronics, lightemitting nanodevices, laser technology, waveguides, pharmaceuticals, biosensors. semiconductors will undoubtedly experience substantial advancements nanotechnology continues advance. entire mechanism regulated with help band theory, which includes valence band, conduction an energy gap, also considered forbidden gaps. These when converted into nano sizes are corresponded nanoparticles, have potential accommodate various functionalities due reduced size, increases better function, adsorption, efficiency, other things discussed book chapter. This chapter focuses on some most important activities now underway problems that must be solved enhance nanostructures nanodevices based semiconductors.

Language: Английский

Citations

21
Novel Approaches to Enzyme-Based Electrochemical Nanobiosensors DOI Creative Commons
Nur Melis Kilic, Sima Singh, Gulsu Keles

et al.

Biosensors, Journal Year: 2023, Volume and Issue: 13(6), P. 622 - 622

Published: June 5, 2023

Electrochemistry is a genuinely interdisciplinary science that may be used in various physical, chemical, and biological domains. Moreover, using biosensors to quantify or biochemical processes critical medical, biological, biotechnological applications. Nowadays, there are several electrochemical for healthcare applications, such as the determination of glucose, lactate, catecholamines, nucleic acid, uric so on. Enzyme-based analytical techniques rely on detecting co-substrate or, more precisely, products catalyzed reaction. The glucose oxidase enzyme generally enzyme-based measure tears, blood, etc. among all nanomaterials, carbon-based nanomaterials have been utilized thanks unique properties carbon. sensitivity can up pM levels nanobiosensor, these sensors very selective, enzymes specific their substrates. Furthermore, frequently fast reaction times, allowing real-time monitoring analyses. These biosensors, however, drawbacks. Changes temperature, pH, other environmental factors influence stability activity enzymes, affecting reliability repeatability readings. Additionally, cost immobilization onto appropriate transducer surfaces might prohibitively expensive, impeding large-scale commercialization widespread use biosensors. This review discusses design, detection, nanobiosensors, recent applications studies evaluated tabulated.

Language: Английский

Citations

36
A review of cross-scale and cross-modal intelligent sensing and detection technology for food quality: mechanism analysis, decoupling strategy and integrated applications DOI
Wentao Huang,

Maosong Yin,

Jie Xia

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 151, P. 104646 - 104646

Published: July 20, 2024

Language: Английский

Citations

12
Real-Time Biosensing Bacteria and Virus with Quartz Crystal Microbalance: Recent Advances, Opportunities, and Challenges DOI

Farzaneh Bonyadi,

Murat Kavruk, Samet Uçak

et al.

Critical Reviews in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 54(8), P. 2888 - 2899

Published: May 16, 2023

Continuous monitoring of pathogens finds applications in environmental, medical, and food industry settings. Quartz crystal microbalance (QCM) is one the promising methods for real-time detection bacteria viruses. QCM a technology that utilizes piezoelectric principles to measure mass commonly used detecting chemicals adhering surface. Due its high sensitivity rapid times, biosensors have attracted considerable attention as potential method infections early tracking course diseases, making it tool global public health professionals fight against infectious diseases. This review first provides an overview biosensing method, including principle operation, various recognition elements biosensor creation, limitations then summarizes notable examples pathogens, focusing on microfluidic magnetic separation techniques pretreatment samples. The explores use sensors samples, such food, wastewater, biological also discusses nanoparticles sample preparation their integration into devices automated highlights importance accurate sensitive diagnosis need point-of-care approaches simplify reduce cost operation.

Language: Английский

Citations

17
Nanoparticles-assisted aptamer biosensing for the detection of environmental pathogens DOI
Kamal Rahimizadeh, Qurat ul ain Zahra, Suxiang Chen

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 117123 - 117123

Published: Sept. 16, 2023

Language: Английский

Citations

13
Rapid and Sensitive Biosensing of Salmonella Using Mechanical Step Rotation and Gold@platinum Nanozymatic Amplification DOI
Meixuan Li, Lei Wang,

Ai Xu

et al.

Journal of Analysis and Testing, Journal Year: 2024, Volume and Issue: 8(3), P. 262 - 269

Published: May 12, 2024

Language: Английский

Citations

4
Detecting Bacteria with Ultralow Concentrations by Enzymatic Cascade Reaction–Amplifying Strategy DOI

Qingzhi Peng,

Huakun Wan,

Zhenguo Yu

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(37), P. 14826 - 14834

Published: Sept. 4, 2024

Bacteria can cause infectious diseases even at ultralow concentrations (<1 CFU/mL). It is important to rapidly identify bacterial contamination concentrations. Herein, FITC-labeled gelatinase-sensitive nanoparticles (GNPs@FITCs) and NFM@GNP@FITCs are designed fabricated as concentration bacteria detection platforms based on an enzymatic cascade reaction-amplifying strategy. Bacterial secretions could trigger the dissociation of GNPs@FITCs release FITC, with gelatinase used model secretion. The detectable signal be amplified effectively by gelatinase-triggered reaction. was evaluated change in fluorescence density. results showed that for identifying qualitatively, when lower than 1 CFU/mL. Moreover, method has better timeliness convenience, compared national standards. As solid films, have long-term storage stability GNPs@FITCs. potential applications GNPs@FITC were proved detecting pathogenic food. All great screening qualitatively.

Language: Английский

Citations

3