Age-related macular degeneration

Nature Reviews Disease Primers, Journal Year: 2021, Volume and Issue: 7(1)

Published: May 6, 2021

Language: Английский

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Understanding the retinal basis of vision across species

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 21(1), P. 5 - 20

Published: Nov. 28, 2019

Language: Английский

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Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies

Investigative Ophthalmology & Visual Science, Journal Year: 2018, Volume and Issue: 59(4), P. AMD160 - AMD160

Published: Oct. 23, 2018

AMD is a major cause of legal blindness in older adults approachable through multidisciplinary research involving human tissues and patients. vascular-metabolic-inflammatory disease, which two sets extracellular deposits, soft drusen/basal linear deposit (BLinD) subretinal drusenoid (SDD), confer risk for end-stages atrophy neovascularization. Understanding how deposits form can lead to insights new preventions therapy. The topographic correspondence BLinD SDD with cones rods, respectively, suggest newly realized exchange pathways among outer retinal cells across Bruch's membrane the space, service highly evolved, eye-specific physiology. This review focuses on drusen/BLinD, summarizing evidence that ultrastructural component large apolipoprotein B,E-containing, cholesterol-rich lipoproteins secreted by pigment epithelium (RPE) offload unneeded lipids dietary segment origin create an atherosclerosis-like progression subRPE-basal lamina space. Clinical observations RPE cell culture system combine drusen/BLinD when secretions functional back up space impaired egress aged membrane-choriocapillary endothelium. drusen lifecycle includes growth, anterior migration atop drusen, then collapse, atrophy. Proof-of-concept studies humans animal models targeting "Oil Spill membrane" offers promise treating process early underlies both end-stages. A companion article addresses antecedents within biology macula.

Language: Английский

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Neural control of choroidal blood flow

Progress in Retinal and Eye Research, Journal Year: 2017, Volume and Issue: 64, P. 96 - 130

Published: Dec. 9, 2017

The choroid is richly innervated by parasympathetic, sympathetic and trigeminal sensory nerve fibers that regulate choroidal blood flow in birds mammals, presumably other vertebrate classes as well. parasympathetic innervation has been shown to vasodilate increase flow, the input vasoconstrict decrease both convey pain thermal information centrally act locally flow. As lies behind retina cannot respond readily retinal metabolic signals, its important for adjustments required either activity, fluctuations systemic pressure driving perfusion, possibly temperature. former two appear be mediated nervous systems, via central circuits responsive activity pressure, but ocular perfusion also influenced local autoregulatory myogenic mechanisms. Adaptive responses temperature may fibers. Impairments neural control of occur with aging, various or diseases such glaucoma, age-related macular degeneration (AMD), hypertension, diabetes, contribute pathology dysfunction these conditions, case AMD a precondition. present manuscript reviews findings mammals above-summarized understanding roles autonomic controlling importance regulation maintaining health.

Language: Английский

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Retina Metabolism and Metabolism in the Pigmented Epithelium: A Busy Intersection

Annual Review of Vision Science, Journal Year: 2021, Volume and Issue: 7(1), P. 665 - 692

Published: June 8, 2021

The outer retina is nourished from the choroid, a capillary bed just inside sclera. O2, glucose, and other nutrients diffuse out of choroid then filter through monolayer retinal pigment epithelium (RPE) cells to fuel retina. Recent studies energy metabolism have revealed striking differences between retinas RPE in ways that they extract fuels. purpose this review suggest evaluate hypothesis complementary metabolic roles make them depend on each for survival their abilities perform essential specialized functions.

Language: Английский

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Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(7)

Published: July 29, 2022

Oxidative stress and hypoxia in the retinal pigment epithelium (RPE) have long been considered major risk factors pathophysiology of age-related macular degeneration (AMD), but systematic investigation interplay between these two was lacking. For this purpose, we treated a human RPE cell line (ARPE-19) with sodium iodate (SI), an oxidative agent, together dimethyloxalylglycine (DMOG) which leads to stabilization hypoxia-inducible (HIFs), key regulators cellular adaptation hypoxic conditions. We found that HIF aggravated stress-induced death by SI iron-dependent ferroptosis identified as main mechanism. Ferroptotic depends on Fenton reaction where H2O2 iron react generate hydroxyl radicals trigger lipid peroxidation. Our findings clearly provide evidence for superoxide dismutase (SOD) driven production fostering indicated triggered SOD activity upon DMOG + treatment well reduced levels SOD2 knockdown. In addition, transporters involved non-transferrin-bound Fe2+ import intracellular were also upregulated. Consequently, chelation 2'2-Bipyridyl completely rescued cells. Taken together, show first time under conditions aggravates ferroptotic Thus, our study provides novel link hypoxia, metabolism AMD pathophysiology. Since accumulation altered are characteristic features retinas cells, culture model is suitable high-throughput screening new approaches against AMD.

Language: Английский

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Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism

Progress in Retinal and Eye Research, Journal Year: 2017, Volume and Issue: 64, P. 131 - 156

Published: Nov. 23, 2017

Language: Английский

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Paracentral acute middle maculopathy and the organization of the retinal capillary plexuses

Progress in Retinal and Eye Research, Journal Year: 2020, Volume and Issue: 81, P. 100884 - 100884

Published: Aug. 9, 2020

Language: Английский

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Paracentral Acute Middle Maculopathy and the Ischemic Cascade Associated With Retinal Vascular Occlusion

American Journal of Ophthalmology, Journal Year: 2018, Volume and Issue: 195, P. 143 - 153

Published: Aug. 3, 2018

Language: Английский

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Human Parafoveal Capillary Vascular Anatomy and Connectivity Revealed by Optical Coherence Tomography Angiography

Investigative Ophthalmology & Visual Science, Journal Year: 2018, Volume and Issue: 59(10), P. 3858 - 3858

Published: Aug. 1, 2018

Purpose: To assess the connection among arterioles, venules, and capillaries in three retinal capillary plexuses using optical coherence tomography angiography (OCTA). Methods: This was a prospective, cross-sectional, observational study including 20 eyes of 10 healthy subjects. En face cross-sectional OCTA images were segmented to superficial (SCP), middle (MCP), deep (DCP). Using thin slabs manual segmentation within plexuses, we examined connections between large-caliber vessels 3 × mm2 scan (arterioles venules) smaller each plexus. Results: Twenty subjects (5 females; average age 30.8 ± 6.3 years) included analysis. We identified vascular interconnections linking arterioles venules with plexus (SCP, MCP, DCP). found DCP crossed horizontal raphe. Conclusions: Our findings show that parafovea has its own feeding arteriolar supply draining supporting physiologic model which controls oxygenated blood match metabolic needs distinct neurovascular unit.

Language: Английский

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