Efficacy of Retinal Maturity Progress on Retinopathy of Prematurity Type 1 Patient Using Intravitreal Bevacizumab Injection Treatment: a Cross-Sectional Study DOI Creative Commons

Aulia Ramadhan

African Journal of Biomedical Research, Journal Year: 2024, Volume and Issue: unknown, P. 6111 - 6116

Published: Dec. 9, 2024

Background: Retinopathy of prematurity (ROP) is a developmental disease retinal blood vessels in premature newborn and remains major cause child blindness worldwide. This study aimed to analyze the efficacy several therapies on maturity progress ROP type 1 patients that have been carried out at Dr Soetomo General Academic Hospital. Method: present used analytical observational method with retrospective cross-sectional design. The secondary data was obtained from medical records Soetomo, who were diagnosed period 6 years. Data such as photocoagulation laser therapy, anti-vascular endothelial growth factor (VEGF) therapy using intravitreal bevacizumab (IVB) injection, vitrectomy therapy. Results: Analysis received showed no significant difference (p = 0.908, r 0.126). By contrast, only IVB injection results 0.034, 0.341). Patients had high cure rate (96.8%) health development, percentage development 3.2%. odd ratio 15.00 indicated 15 times greater chance than did not receive injection. Conclusion: findings use injections significantly improved success Thus, most effective this an

Language: Английский

Construction of a nomogram model to predict the risk of retinopathy of prematurity reactivate after intravitreal anti-vascular endothelial growth factor therapy: a retrospective study DOI Creative Commons
Ziyun Shen,

Qingfei Hao,

Tiantian Yang

et al.

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 7, 2025

To explore the risk factors for reactivate of retinopathy prematurity (ROP) after intravitreal injection anti-vascular endothelial growth factor (VEGF) and to construct a nomogram model predict ROP reactivate. A retrospective analysis was conducted on 185 children who underwent anti-VEGF treatment at First Affiliated Hospital Zhengzhou University from January 2017 October 2023. They were randomly divided into training set (129 cases) validation (56 ratio 7:3. The further group (n = 18) non-reactivate 111) based whether recurred treatment. Multivariable logistic regression used screen constructed using R software validated set. discrimination, calibration, clinical net benefit evaluated receiver operating characteristic curve (ROC curve), calibration curve, decision analysis, respectively. showed that number red blood cell transfusions, use pulmonary surfactant (PS) 2 times or more, preoperative fundus hemorrhage independent (P < 0.05). area under ROC (AUC) 0.810 (95% CI: 0.706-0.914), 0.756 0.639-0.873). Hosmer-Leme show goodness-of-fit test indicated good fit 0.31). Calibration suggested high predictive efficacy application value model. PS are these has value.

Language: Английский

Citations

0
Predictors of Length of Hospitalization for Neonatal Sepsis at Kenyatta Nation Hospital, Kenya: A Prospective Cross‐Sectional Study DOI Creative Commons

Athman Khaltuma Tisho,

Patrick Mbugua,

Rose Bosire

et al.

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 1, 2025

ABSTRACT Background and Aims Neonatal sepsis is a major cause of neonatal mortality worldwide. It remains detrimental bottleneck to the WHO goal eradicating preventable deaths for children below 5 years age by 2030. Though risk factors adverse clinical outcomes have been widely studied there no universal consensus. Length hospitalization considered an indicator outcome sepsis. Markedly, literature scarce regarding drivers extended in Kenya. Methodology This study determined predictors prolonged hospital stay at pediatric wards, KNH, was prospective cross‐sectional research carried out among 314 mother/neonate pairs. The neonates were confirmed Logistic regression analysis conducted determine maternal neonate status predictive duration hospitalization. Results median 11 days majority (52.9%) hospitalized more than days. findings identified that ≥ 35 (OR = 3.72, 95% CI: 1.61–8.59, p 0.03), UTI during pregnancy 1.82, 1.07–3.11, not breastfeeding 2.31, 1.29–4.14, 0.005), convulsion 2.03, 1.22–3.37, 0.01), jaundice 1.45, 1.10–1.91, 0.002), reduced movements 1.72, 1.08–2.72, 0.02), low birthweight 6.1, 2.48–14.99, < 0.001) preterm birth 3.1, 1.64–5.86, significant longer stay. Conclusion provide insights into can be monitored predict prognosis Besides, remedies target these variables mitigate severity

Language: Английский

Citations

0
The Impact of Low Birth Weight and Gestational Age on Premature Retinopathy Outcomes DOI Open Access
Çağrı MUTAF, Ali Hakim Reyhan, İrfan Uzun

et al.

Harran Üniversitesi Tıp Fakültesi Dergisi, Journal Year: 2025, Volume and Issue: 22(1), P. 26 - 31

Published: March 10, 2025

Background: The study aimed to investigate the incidence and treatment of retinopathy prematu-rity (ROP) in premature infants, focusing on its relationship with gestational age birth weight. Materials Methods: This retrospective analyzed 1101 infants a 34 weeks or less and/or weight 1700 grams less, screened for ROP between 2021 2023. Results: Fifty-five required treatment. was higher lower earlier groups. Among weighing 1000 56.1% developed ROP, compared 43% 1001-1250 gram category 28.1% 1251-1700 category. For age, 53.2% than 27 weeks, 26.8% 27-34 12.7% over ROP. Conclusions: Premature especially those very low early are at high risk necessitating comprehensive screening timely intervention.

Language: Английский

Citations

0
Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants DOI Creative Commons
Kirsten Glaser,

Christoph Härtel,

Claus Klingenberg

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(7), P. e2423933 - e2423933

Published: July 25, 2024

Importance Retinopathy of prematurity (ROP) is a major morbidity preterm infants causing visual impairment, including blindness, for which timely treatment vital and prevention key. Increasing evidence suggests that exposure to neonatal sepsis contributes ROP development. Objective To investigate the association between in 2 large-scale cohorts born at less than 29 weeks’ gestation. Design, Setting, Participants This retrospective cohort study was conducted using data from German Neonatal Network (GNN) Norwegian (NNN). The GNN involves 68 NNN includes 21 level III intensive care units. were gestation 22 weeks 0 days 28 6 enrolled January 1, 2009, December 31, 2022, 2018. Data analyzed February through September 2023. Exposure Single or multiple episodes culture-proven sepsis. Main Outcomes Measures Any treatment-warranted ROP. Results Among 12 794 (6043 female [47.2%] 6751 male [52.8%]; mean [SD] gestational age, 26.4 [1.5] weeks) 1844 (866 [47.0%] 978 [53.0%]; 25.6 weeks), (SD) birth weight 848 (229) g 807 (215) g, respectively. present 6370 (49.8%) 620 (33.6%) NNN, 840 (6.6%) 140 (7.6%) NNN. In both cohorts, there increasing rates with each episode (no sepsis: 572 10 658 [5.4%] 85 1492 (5.7%) NNN; 1 episode: 190 1738 [10.9%] 293 [9.9%] episodes: 53 314 [16.9%] 13 49 [26.5%] 3 25 84 [29.8%] [30.0%] NNN). After adjusting confounders dataset, number associated compared (1 adjusted odds ratio [aOR], 1.44 [95% CI, 1.27-1.63]; P &amp;lt; .001 OR, 1.60 1.31-1.96]; .001, respectively; 1.81 1.35-2.42]; 2.38 1.68-3.37]; 4.39 2.19-8.78]; 3.88 2.29-6.55]; respectively). These associations confirmed any by propensity score matching (for example, aOR 1.76 1.54-2.02]; vs 1.58 1.12-2.22]; = .007 episode). surgical NEC (multivariable analysis: aOR, 3.37 1.78-6.37]; .001). Conclusions Relevance found cohort, recurrent weeks.

Language: Английский

Citations

3
Retinopathy of Prematurity in Eight Portuguese Neonatal Intensive Care Units: Incidence, Risk Factors, and Progression—A Prospective Multicenter Study DOI Creative Commons
Mariza Fevereiro‐Martins, Ana Carolina Santos, Carlos Marques‐Neves

et al.

Children, Journal Year: 2024, Volume and Issue: 11(10), P. 1154 - 1154

Published: Sept. 24, 2024

Retinopathy of prematurity (ROP) is a retinal neovascular disease affecting preterm infants. Identifying risk factors for its development and progression critical effective screening prevention. This study aimed to analyze the incidence ROP identify key progression.

Language: Английский

Citations

2
Risk factors for severe retinopathy of prematurity stratified by birth weight and gestational age in privately insured infants DOI

John Moir,

Max J. Hyman, Dimitra Skondra

et al.

Journal of American Association for Pediatric Ophthalmology and Strabismus, Journal Year: 2024, Volume and Issue: 28(6), P. 104049 - 104049

Published: Nov. 15, 2024

Language: Английский

Citations

2
Enhancing the Retinopathy Of Prematurity Risk Profile Through Placental Evaluation of Maternal and Fetal Vascular Malperfusion DOI Creative Commons
Salma El Emrani,

Esther J. S. Jansen,

Jelle J. Goeman

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(11), P. 9 - 9

Published: Sept. 4, 2024

To determine the independent effect of uteroplacental malperfusion on development retinopathy prematurity (ROP).

Language: Английский

Citations

1
Retinopathy of prematurity comes full circle DOI
Alistair R. Fielder, Graham E. Quinn, Parag K. Shah

et al.

Archives of Disease in Childhood Fetal & Neonatal, Journal Year: 2024, Volume and Issue: unknown, P. fetalneonatal - 327003

Published: April 11, 2024

Language: Английский

Citations

0
Genetic risk and retinopathy of prematurity: homing in on a target? DOI

Abdelhakim Morsy,

Brian K. Stansfield

Pediatric Research, Journal Year: 2024, Volume and Issue: unknown

Published: June 11, 2024

Language: Английский

Citations

0
Early-Onset Sepsis as an Early Predictor for Retinopathy of Prematurity: A Meta-analysis DOI Creative Commons
Salma El Emrani, Lotte E. van der Meeren,

Esther J. S. Jansen

et al.

American Journal of Perinatology, Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Neonatal sepsis has been established as a risk factor for retinopathy of prematurity (ROP) but previous meta-analyses have predominately focused on late-onset (LOS). This meta-analysis aims to explore the association between early-onset (EOS) and ROP.

Language: Английский

Citations

0