Exploring the role of NLRP3 infalmmasome in diabetes: a literature review and bibliometric analysis DOI Creative Commons
Yi Jer Tan, Shaotao Chen,

Tianjiao Gao

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Diabetes has emerged as the foremost public health challenge of 21st century, with a notable shift towards managing it through an inflammatory lens. This study seeks to investigate role NLRP3 infalmmasome in diabetes over past ten years, leveraging bibliometric analysis pinpoint prevailing trends, underscore critical focal points, and establish roadmap for subsequent research endeavors.

Language: Английский

Retinal Pigment Epithelium Under Oxidative Stress: Chaperoning Autophagy and Beyond DOI Open Access
Yu. V. Markitantova, V. N. Simirskii

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1193 - 1193

Published: Jan. 30, 2025

The structural and functional integrity of the retinal pigment epithelium (RPE) plays a key role in normal functioning visual system. RPE cells are characterized by an efficient system photoreceptor outer segment phagocytosis, high metabolic activity, risk oxidative damage. dysfunction is common pathological feature various diseases. Dysregulation cell proteostasis redox homeostasis accompanied increased reactive oxygen species generation during impairment lysosomal mitochondrial failure, accumulation waste lipidic protein aggregates. They inducers can trigger specific pathways death. Autophagy serves as important mechanism endogenous defense system, controlling survival under conditions cellular responses stress through degradation intracellular components. Impairment autophagy process itself result In this review, we summarize classical types stress-induced with emphasis on mediated molecular chaperones. Heat shock proteins, which represent hubs connecting life supporting cells, play special these mechanisms. Regulation stress-counteracting essential strategy for protecting against damage when preventing degenerative disease progression.

Language: Английский

Citations

2
Practical Applications of Artificial Intelligence Diagnostic Systems in Fundus Retinal Disease Screening DOI Creative Commons

Qingquan Wei,

Lifang Chi,

Meiling Li

et al.

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 1173 - 1180

Published: Feb. 28, 2025

This study aims to evaluate the performance of a deep learning-based artificial intelligence (AI) diagnostic system in analysis retinal diseases, assessing its consistency with expert diagnoses and overall utility screening applications. A total 3076 patients attending our hospital underwent comprehensive ophthalmic examinations. Initial assessments were performed using AI, Comprehensive AI Retinal Expert (CARE) system, followed by thorough manual reviews establish final diagnoses. comparative was conducted between AI-generated results evaluations senior ophthalmologists assess reliability feasibility context screening. : The demonstrated sensitivity 94.12% specificity 98.60% for diabetic retinopathy (DR); 89.50% 98.33% age-related macular degeneration (AMD); 91.55% 97.40% suspected glaucoma; 90.77% 99.10% pathological myopia; 81.58% 99.49% vein occlusion (RVO); 88.64% 99.18% detachment; 83.33% 99.80% hole; 82.26% 99.23% epiretinal membrane; 94.55% 97.82% hypertensive retinopathy; 99.74% myelinated fibers; 75.00% 99.95% retinitis pigmentosa. Additionally, exhibited notable other prevalent conditions, including DR, glaucoma, myopia, retinopathy. AI-assisted exhibits high majority suggesting potential as valuable tool practices. Its implementation is particularly beneficial grassroots community healthcare settings, facilitating initial efforts enhancing efficacy tiered care, important implications broader clinical adoption.

Language: Английский

Citations

0
Significance of Macrophage-Mediated Inflammatory Response in Ocular Inflammatory Complications DOI Creative Commons

Stacey J. McMahon,

T. D. Spector,

Kota V. Ramana

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(3)

Published: March 18, 2025

Immune cells such as macrophages play a significant role in ocular inflammation by activating or inhibiting several cellular pathways. Systemic infections and autoimmune diseases could activate releasing various pro-inflammatory cytokines, chemokines, growth factors, which reach the eyes through blood-retina barrier cause immune inflammatory responses. In addition, environmental pollutants, allergens, eye injuries also an response. Further, response generated recruit additional enhance The leads to tissue damage dysfunction affects vision. Macrophages are generally implicated clearance of pathogens debris, generate reactive oxygen species, initiate However, uncontrolled responses tissues, leading complications uveitis, scleritis, diabetic retinopathy, retinitis. Recent studies describe individual cytokines mediation specific diseases. this article, we discussed potential impact their mediated on development possible treatment strategies.

Language: Английский

Citations

0
Regulated cell death in age-related macular degeneration: regulatory mechanisms and therapeutic potential DOI Creative Commons
Lele Zhang,

Jia-Mei Yu,

Zhaochuan Fan

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101285 - 101285

Published: March 1, 2025

Language: Английский

Citations

0
The Regulatory Role of NcRNAs in Pyroptosis and Disease Pathogenesis DOI

Shaocong Wang,

Xinzhe Chen, Kun Wang

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

Citations

0
Mechanism and Therapeutic Targets of Circulating Immune Cells in Diabetic Retinopathy DOI Creative Commons
Bowen Zhao, Yin Zhao, Xufang Sun

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 210, P. 107505 - 107505

Published: Nov. 14, 2024

Diabetic retinopathy (DR) continues to be the leading cause of preventable vision loss among working-aged adults, marked by immune dysregulation within retinal microenvironment. Typically, retina is considered as an immune-privileged organ, where circulating cells are restricted from entry under normal conditions. However, during progression DR, this privilege compromised breach barrier and infiltrate retina. Increasing evidence suggests that vascular neuronal degeneration in DR largely driven infiltration cells, particularly neutrophils, monocyte-derived macrophages, lymphocytes. This review delves into mechanisms therapeutic targets associated with these cell populations offering a promising innovative approach managing disease.

Language: Английский

Citations

1
Run-Mu-Ling Granules Mitigate Ocular Surface Inflammatory Injury Associated with Dry Eye by Suppressing the NLRP3/GSDMD-Mediated Pyroptosis Pathway DOI Creative Commons
Dan Luo,

Hongguang Ji,

X.X. Yan

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 10769 - 10784

Published: Dec. 1, 2024

Run-Mu-Ling granules (RMLG), a traditional Chinese medicinal formula, are used to treat dry eye (DE); however, the underlying mechanism remains poorly understood. This study aimed elucidate potential molecular mechanisms by which RMLG alleviates ocular surface inflammation in DE.

Language: Английский

Citations

1
Loneliness and social isolation are associated with an increased risk of glaucoma: a UK Biobank cohort study DOI Creative Commons
Xinyu Zhu, Bo Li, Xinyu Zhang

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 5, 2024

Abstract Background Loneliness and social isolation have been found to be associated with various health-related outcomes. Our study aimed evaluate the association of loneliness risk glaucoma. Methods A total 373,330 participants from UK Biobank without glaucoma at recruitment were included in this study. Self-reported questionnaires used define isolation. Incident events identified by hospital inpatient admissions self-reported data. COX proportional hazards models adjusted for sociodemographic, lifestyle, factors estimate hazard ratios (HRs) 95% CIs. Results During a median follow-up 13.1 (interquartile range: 12.3–13.9) years, 6,489 developed After adjusting confounding factors, (yes vs. no: HR: 1.16; CI: 1.04–1.30; P = 0.009) 1.08; 1.01–1.16; 0.033) an increased Conclusions In population-based prospective cohort study, higher

Language: Английский

Citations

0
Machine learning-based identification and validation of immune-related biomarkers for early diagnosis and targeted therapy in diabetic retinopathy DOI

Yulin Tao,

Minqi Xiong,

Yingchuan Peng

et al.

Gene, Journal Year: 2024, Volume and Issue: 934, P. 149015 - 149015

Published: Oct. 18, 2024

Language: Английский

Citations

0
Exploring the role of NLRP3 infalmmasome in diabetes: a literature review and bibliometric analysis DOI Creative Commons
Yi Jer Tan, Shaotao Chen,

Tianjiao Gao

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Diabetes has emerged as the foremost public health challenge of 21st century, with a notable shift towards managing it through an inflammatory lens. This study seeks to investigate role NLRP3 infalmmasome in diabetes over past ten years, leveraging bibliometric analysis pinpoint prevailing trends, underscore critical focal points, and establish roadmap for subsequent research endeavors.

Language: Английский

Citations

0