Mechanism and Therapeutic Targets of Circulating Immune Cells in Diabetic Retinopathy DOI Creative Commons
Bowen Zhao, Yin Zhao, Xufang Sun

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 210, P. 107505 - 107505

Published: Nov. 14, 2024

Diabetic retinopathy (DR) continues to be the leading cause of preventable vision loss among working-aged adults, marked by immune dysregulation within retinal microenvironment. Typically, retina is considered as an immune-privileged organ, where circulating cells are restricted from entry under normal conditions. However, during progression DR, this privilege compromised breach barrier and infiltrate retina. Increasing evidence suggests that vascular neuronal degeneration in DR largely driven infiltration cells, particularly neutrophils, monocyte-derived macrophages, lymphocytes. This review delves into mechanisms therapeutic targets associated with these cell populations offering a promising innovative approach managing disease.

Language: Английский

Shared signaling pathways and comprehensive therapeutic approaches among diabetes complications DOI Creative Commons
Moein Ebrahimi, Hamid Ahmadieh, Mozhgan Rezaei Kanavi

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 8, 2025

The growing global prevalence of diabetes mellitus (DM), along with its associated complications, continues to rise. When clinically detected most DM complications are irreversible. It is therefore crucial detect and address these early systematically in order improve patient care outcomes. current clinical practice often prioritizes by addressing one complication while overlooking others that could occur. proposed the commonly targeted cell types including vascular cells, immune glial fibroblasts mediate might share responses diabetes. In addition, impact be influenced other complications. Recognizing focusing on shared among impacted cellular constituents, will allow simultaneously all DM-related limit adverse treatment impacts. This review explores understanding pathological signaling mechanisms recognizes new concepts benefit from further investigation both basic settings. ultimate goal develop more comprehensive strategies, which effectively multiple organs

Language: Английский

Citations

1
A Triple‐Integrated 3D‐Printed Composite Scaffold of High‐Activity Peptide‐Metal Ion‐Bone Cement Facilitates Osteo‐Vascular Regenerative Repair of Diabetic Bone Defects DOI Open Access
Junwu Wang,

Yuhao Xia,

Zhuowen Hao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Hyperglycemia and its induced oxidative stress microenvironment present formidable challenges to the repair of diabetic bone defects. Herein, a novel TZGP (α‐TCP/ZnO/GM@P2) composite scaffold for defect is developed. Characterization results demonstrate that α‐TCP cement scaffold, ZnO nanoparticles, gelatin microspheres loaded with protecting P2 (a parathyroid hormone‐related peptide) achieve complementary advantages. The while meeting mechanical strength requirements cancellous bone, compensates deficiency bioactive peptides in inorganic scaffolds. Its biocompatibility enhanced, endowed antibacterial antioxidant properties. vitro vivo reveal releases active factors Zn 2+ , promotes cell proliferation recruitment high‐glucose microenvironment, reduces cellular reactive oxygen species accumulation, improves DNA injury mitochondrial homeostasis, induces osteogenic‐angiogenic differentiation. Compared conventional exhibits more excellent biodegradability, accelerates local tissue filling, accumulation vascular reconstruction Consequently, design strategy offers promising approach repairing

Language: Английский

Citations

1
Smart self-healing hydrogel wound dressings for diabetic wound treatment DOI

Yuelin Hu,

Dejia Xv,

Chaoming Xie

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Feb. 18, 2025

Diabetic wounds are difficult to treat clinically because they heal poorly, often leading severe complications such as infections and amputations. Hydrogels with smart self-healing properties show great promise for treating diabetic wounds. These hydrogels capable of continuously dynamically responding changes in the wound environment, feature improved mechanical qualities capacity self-heal damage. We explore latest developments healing this review. First, we systematically summarize obstacles then highlighted significance hydrogels, explaining their stimulus-responsive mechanisms design approaches, along applications addressing these challenges. Finally, discussed unresolved potential avenues future research. anticipate that review will facilitate continued refinement dressings, aiming broader clinical adoption.

Language: Английский

Citations

0
YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy DOI Creative Commons

Xiang Lei,

Xiu Jun Wang,

X. Zhang

et al.

Journal of Diabetes Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Phosphoglycerate dehydrogenase (PHGDH), which controls serine synthesis, has been linked to retinal disease. However, there are no clues about its involvement in the diabetic retinopathy (DR) progression. Therefore, we aimed investigate relationship between PHGDH, and DR their underlying molecular mechanisms. Differentially expressed genes were screened using bioinformatics tools. mice induced, histopathology was observed mice. Overexpression of PHGDH induced measure l-serine, ROS, MDA content retinas ARPE-19 cells transfected with overexpression exposed high glucose induce a vitro model, cell viability apoptosis assays, content, oxidative stress factor measurement conducted. The transcriptional regulation by YY2 explored ChIP dual-luciferase reporter assays. Finally, combined role regulating stress, ferroptosis investigated. expression reduced mice, alleviated progression promoting synthesis attenuating stress. bound promoter mediated repression. YY2-mediated repression caused disturbances leading stress-triggered ferroptosis. Our data prove that plays vital modulating expression, impairing expediting

Language: Английский

Citations

0
Effect of the Mediterranean Diet (MeDi) on the Progression of Retinal Disease: A Narrative Review DOI Open Access

Oualid Sbai,

Filippo Torrisi, Federico Pio Fabrizio

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3169 - 3169

Published: Sept. 19, 2024

Worldwide, the number of individuals suffering from visual impairment, as well those affected by blindness, is about 600 million and it will further increase in coming decades. These diseases also seriously affect quality life working-age individuals. Beyond characterization metabolic, genetic, environmental factors related to ocular pathologies, important verify how lifestyle may participate induction molecular pathways underlying these diseases. On other hand, scientific studies are contributing investigations whether could intervene modulating pathophysiological cellular responses, including production metabolites neurohormonal factors, through intake natural compounds capable interfering with mechanisms that lead Nutraceuticals promising ameliorating complications disease such inflammation neurodegeneration. Moreover, characterize nutritional patterns and/or be beneficial against certain The adherence Mediterranean diet (MeDi) proposed a intervention for prevention amelioration several eye Several characteristic micronutrients MeDi, vitamins, carotenoids, flavonoids, omega-3 fatty acids, adjuvants In this review, we focus on analyze effects MeDi diabetic retinopathy, macular degeneration, glaucoma. analysis knowledge field requested order provide direction recommendations interventions aimed prevent ameliorate

Language: Английский

Citations

4
Nintedanib abrogates patient vitreous-induced Akt activation and tube formation of human retinal microvascular endothelial cells DOI
Qiang Li, Xiaoping Zhou,

Yanhui Yang

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 94, P. 102817 - 102817

Published: March 1, 2025

Language: Английский

Citations

0
Mechanism and Therapeutic Targets of Circulating Immune Cells in Diabetic Retinopathy DOI Creative Commons
Bowen Zhao, Yin Zhao, Xufang Sun

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 210, P. 107505 - 107505

Published: Nov. 14, 2024

Diabetic retinopathy (DR) continues to be the leading cause of preventable vision loss among working-aged adults, marked by immune dysregulation within retinal microenvironment. Typically, retina is considered as an immune-privileged organ, where circulating cells are restricted from entry under normal conditions. However, during progression DR, this privilege compromised breach barrier and infiltrate retina. Increasing evidence suggests that vascular neuronal degeneration in DR largely driven infiltration cells, particularly neutrophils, monocyte-derived macrophages, lymphocytes. This review delves into mechanisms therapeutic targets associated with these cell populations offering a promising innovative approach managing disease.

Language: Английский

Citations

1