Evaluation of antimicrobial, antioxidant, and anti-inflammatory abilities of sustainably synthesized Co3O4 NPs

Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 56, P. 103025 - 103025

Published: Jan. 29, 2024

Language: Английский

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Synthesis and characterization of marine seagrass (Cymodocea serrulata) mediated titanium dioxide nanoparticles for antibacterial, antibiofilm and antioxidant properties

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 189, P. 106595 - 106595

Published: Feb. 20, 2024

Language: Английский

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Fabrication and Characterization of Cymodocea serrulata Extract-Mediated Silica Nanoparticles with Antioxidant Properties

National Academy Science Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

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Metabolic Changes of Active Components of Important Medicinal Plants on the basis of Traditional Chinese Medicine under Different Environmental Stresses

Current Organic Chemistry, Journal Year: 2023, Volume and Issue: 27(9), P. 782 - 806

Published: May 1, 2023

Abstract: Traditional Chinese medicine is an ancient system of wellness and health that has been used in almost all countries the world, specially Asia for thousands years. : The growth, development, final yield chemical compounds medicinal plants can be negatively influenced by different kinds biotic abiotic stresses. Abiotic stress signals are (Mineral salts, heavy metal, aerosols, gaseous toxins, pesticides, pollutants), salinity (salt), temperature (Heat, cold), radiation (Ionisation radiation, light UV), water (Flooding, drought) mechanical (Submergence, wind, soil movement). Relevant literature obtained using keywords “Traditional Medicine”, “Abiotic Stress”, “Biotic “Ginseng”, “Ginger”, “Goji berry”, “Astragalus”, “Ginkgo”, “Artemisia annua L.”, “LC-MS”, “GC-MS”, “NMR” scientific information, namely “Web Science”, “PubMed”, “SciFinder”, “Elsevier”. Some plants’ secondary metabolites under growth conditions Camptothecin (Camptotheca acuminata), Capsaicin (Capsicum sp.), Rosmarinic acid (Salvia miltiorrhiza), Codeine (Papaver somniferum), Resveratrol (Grapes, groundnut), Artemisinin (Artemesia annua), Allicin (Allium sativum), Rohitukine (Dysoxylum binectariferum), Stevioside (Stevia rebaudiana), Andrographolide (Andrographis paniculata), Saikosaponins (Bupleurum chinense), Sennosides (Cassia augustifolia), Rutin (Dimorphandra mollis), Valepotriates (Valeria species), Indole alkaloids (Catharanthus roseous), Furanocoumarins (Bituminaria bituminosa). aim this article a survey active metabolic changes some most important traditional (TCM) both Future research needed to evaluate effects stresses on medicine, more surveys roles LC-MS, GC-MS NMR techniques better understanding components plants.

Language: Английский

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Antioxidant activity, cytotoxicity assay, and evaluation of bioactive compounds using GC-MS and HPTLC-based bioassay in the extracts of Osbeckia stellata var. crinita (Benth. ex Naudin) grown in Manipur, India

Kuwait Journal of Science, Journal Year: 2024, Volume and Issue: 51(3), P. 100229 - 100229

Published: April 4, 2024

In the present study, we aimed to investigate antioxidant, cytotoxicity activities, and phytochemical profiling of O. stellata extracts. Qualitative tests showed presence different groups phytochemicals, mainly in polar solvents. Methanolic hydroalcoholic extracts high total phenolic flavonoid contents. The antioxidant activity was determined by using 2,2-Diphenyl-1-picrylhydrazyl (DPPH), metal chelating, reducing power assay where methanolic (IC50: 24.76 ± 2.78 μg/mL), 29.59 3.44 aqueous 33.72 1.97 μg/mL) significantly potential. Significant observed extract. As extract better gas chromatography–mass spectrometry (GC-MS) analysis identified 41 bioactive compounds, 17 major compounds had medicinal value. High-performance thin layer chromatography (HPTLC) bioassay-guided combined with Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) nuclear magnetic resonance (NMR) spectroscopy characterized gallic caffeic acid as free radical scavengers. This study evidences that has potent anti-cancer properties, which may render oxidative stress-related disease be used for drug development human health benefits.

Language: Английский

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Synthesis of Zinc Oxide Nanoparticles From Cymodocea Serrulata Leaf Extract and Their Biological Activities

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: March 4, 2024

Introduction The utilization of Cymodocea serrulata for the eco-friendly synthesis zinc oxide nanoparticles, which contain distinguishable nanostructures, presents a cost-effective and environmentally sustainable alternative producing nanoparticles. production process nanoparticles are rich in phytochemicals, can serve as stabilizing reducing agents. Zinc easily pass through bacterial cell walls reach all cellular components. C. serrulata, is small submerged angiosperm commonly found tidal coastal environments. Aim Analysis biological activities made from leaf extract. Materials Methods Dry leaves were ground into powder, was then placed conical flask filled with water. Subsequently, color mixture turned black. Next, 20 mm piece ZnO dissolved 60 ml sample distilled water to prepare metal solution. Following this, wavelength scan ranging 200 700 nm conducted using ultraviolet (UV) spectroscopy. After shaking solution an hour, final reading taken across UV spectrum. synthetic should also be centrifuged remove any pellets subsequently dried hot air oven. Result Using nanoscale profiling, average particle size measured less than 100 nm, specifically spectrum analysis revealed notable absorbance value 47.0 at different angles within peak height. range observed between 250 350 nm. Conclusion antibacterial properties NPs have been demonstrated vitro investigations, indicating their potential application vivo studies.

Language: Английский

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Antimicrobial, antioxidant, anticancer, and antithrombotic, competency of saponins from the root of Decalepis hamiltonii

Environmental Research, Journal Year: 2023, Volume and Issue: 231, P. 116096 - 116096

Published: May 10, 2023

Language: Английский

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Seagrass Meadows: Prospective Candidates for Bioactive Molecules

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4596 - 4596

Published: Sept. 27, 2024

Seagrass meadows consist of angiosperms that thrive fully submerged in marine environments and form distinct ecosystems. They provide essential support for many organisms, acting as nursery grounds species economic importance. Beyond their ecological roles, seagrasses associated microbiomes are rich sources bioactive compounds with the potential to address numerous human healthcare challenges. Seagrasses produce molecules responding physical, chemical, biological environmental changes. These activities can treat microbe-borne diseases, skin diabetes, muscle pain, helminthic wounds. also offer secondary metabolites be used societal benefits. Despite results on presence derivatives, only a few studies have explored functional therapeutic properties from seagrass. With increasing spread epidemics pandemics worldwide, demand alternative drug discovery has become an indispensable area research. present reliable natural source, making this opportune moment further exploration pharmacological minimal side effects. This review provides comprehensive overview biochemical, phytochemical, biomedical applications globally over last two decades, highlighting prospective areas future research identifying applications.

Language: Английский

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Antidiabetic, Genoprotective Potential, and Phytoconstituents of Cymodocea serrulata (R. Brown): In vivo, Drug Target Prediction, and ADME Studies

Thalassas An International Journal of Marine Sciences, Journal Year: 2025, Volume and Issue: 41(1)

Published: Feb. 1, 2025

Language: Английский

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Antidiabetic Bioactive Compounds from Juglans regia L. Fruit Endocarp: Isolation, Characterization, and In Silico Molecular Dynamics Simulations

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(14)

Published: April 1, 2025

Abstract This study explores the antidiabetic potential of bioactive compounds isolated from Juglans regia Linn. fruit endocarp fractions. The ethanolic extract was screened for α ‐amylase inhibition, revealing chloroform fraction as most potent (18.45 ± 0.76%), followed by n ‐hexane (12.65 0.52%) and results were compared to acarbose (21.84 1.67%). These further supported nonenzymatic glycosylation hemoglobin assay. Five employing column chromatography both fractions structurally characterized using ¹H NMR ¹ 3 C spectroscopy. Density functional theory (DFT) analysis confirmed their stability reactivity. Molecular docking, molecular dynamics (MD) simulations, MM/GBSA calculations revealed that 2 5 displayed strong interactions with human pancreatic (PDB: 4GQR) 2D60), respectively. quantified binding free energies, reinforcing these interactions, while MD simulations validated dynamic behavior complexes over time, confirming stable inhibitors. ADMET favorable pharmacokinetic toxicity profiles, suggesting promising candidates diabetes treatment. provides a foundation drug development targeting management.

Language: Английский

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