DHA-enriched phosphatidylserine ameliorates cyclophosphamide-induced liver injury via regulating the gut-liver axis

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 140, P. 112895 - 112895

Published: Aug. 11, 2024

Language: Английский

---

Integrative metabolomics and gut microbiota analyses reveal the protective effects of DHA-enriched phosphatidylserine on bisphenol A-induced intestinal damage

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 117, P. 106229 - 106229

Published: May 7, 2024

The protective effects of docosahexaenoic acid-enriched phosphatidylserine (DHA-PS, 50 or 100 mg/kg) on bisphenol A (BPA)-induced intestinal damage were assessed. biochemical indices, pathological examination, non-targeted metabolomics integrated with gut microbiota analysis, and immunofluorescence analysis used to investigate the DHA-PS its underlying regulatory mechanism. treatment improved pathology tract increased expression levels Claudin-1, Occludin, ZO-1. In addition, also notably decreased interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, antioxidant enzymes activities. Moreover, relative abundances Akkermansia, Alistipes, Butyricicoccus, Coriobacteriaceae_UCG-002, Enterorhabdus, Lachnospiraceae_UCG-006. alleviated BPA-induced by regulating kynurenine pathway tryptophan, lipid, arachidonic acid metabolisms. Overall, this study suggested that could alleviate enhancing barrier integrity, improving microbial composition metabolites, inhibiting TLR4/NF-κB pathways.

Language: Английский

---

Docosahexaenoic acid-enriched diet improves the flesh quality of freshwater fish (Megalobrama amblycephala): Evaluation based on nutritional value, texture and flavor

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140518 - 140518

Published: July 19, 2024

Language: Английский

---

Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 172, P. 116250 - 116250

Published: Feb. 5, 2024

Non-alcoholic fatty liver disease (NAFLD) is a substantial global health issue owing to its high prevalence and the lack of effective therapies. Fermentation medicinal herbs has always been considered feasible strategy for enhancing efficacy in treating various ailments. This study aimed investigate potential benefits Lactobacillus casei-fermented Amomum xanthioides (LAX) on NAFLD high-fat diet model. HFD-fed C57BL6/j mice were administered with 200 mg/kg LAX or unfermented (AX) 100 metformin 6 weeks from 4th week. The 10-week HFD-induced alterations hepatic lipid accumulation inflammation significantly attenuated by dominantly (more than AX metformin), which evidenced pathohistological findings, contents, inflammatory cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)− IL-1β, oxidative parameters such as reactive oxygen species (ROS) malondialdehyde (MDA), molecular changes reversely between lipogenic proteins glycerol-3-phosphate acyltransferase (GPAM) sterol regulatory element-binding protein (SREBP)− 1, lipolytic peroxisome proliferator-activated receptor (PPAR-α) AMP-activated kinase (AMPK)-α tissues. In addition, abnormal serum (triglyceride, total cholesterol LDL-cholesterol) notably ameliorated LAX. conclusion, these findings support promising plant-derived remedy NAFLD.

Language: Английский

---

Supplementation of Micro- and Macronutrients—A Role of Nutritional Status in Non-Alcoholic Fatty Liver Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4916 - 4916

Published: April 30, 2024

Non-alcoholic fatty liver disease (NAFLD) is a condition in which the pathological cumulation of fat with coexisting inflammation and damage hepatic cells leads to progressive dysfunctions liver. Except for commonly well-known major causes NAFLD such as obesity, dyslipidemia, insulin resistance, or diabetes, an unbalanced diet imbalanced nutritional status should also be taken into consideration. In this narrative review, we summarized current knowledge regarding micro- macronutrient patients suffering from considering various diets supplementation chosen supplements. We aimed summarize indicating impairments may associated onset progression at same time evaluating potential therapy targets that could facilitate healing process. above-mentioned objectives, one most important aspects review was highlight possible strategies taking care account challenges opportunities micronutrient patients. The research indicates vitamins (e.g., vitamin A, B complex, C, D) well elements zinc alleviate symptoms NAFLD. However, there still lack sufficient data healthy ranges dosages; thus, further high importance matter.

Language: Английский

---

Silymarin mediates the gut-liver axis pathway to alleviate Carassius auratus hepatic lipid metabolism disorders caused by carbonate exposure

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2025, Volume and Issue: 55, P. 101457 - 101457

Published: Feb. 27, 2025

Language: Английский

---

Differential effects of ellagic acid on non-alcoholic fatty liver disease in mice: grouped by urolithin A-producing capacity

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Ellagic acid (EA) exhibits protective effects on non-alcoholic fatty liver disease (NAFLD). However, the ability to produce urolithins and health benefits associated with EA consumption differ considerably among individuals. Therefore, different of high-fat high-fructose diet (HFFD)-induced NAFLD, considering variability in urolithin-producing ability, were explored. Our results showed that could effectively reduce body weight, lipid accumulation insulin resistance, improve oxidative stress inflammation NAFLD mice. The metabolomics analysis indicated metabolism disorder induced by HFFD was obviously improved mainly through regulation unsaturated biosynthesis amino metabolism. In particular, improvement effect mice high urolithin A production better than their low counterparts. Moreover, treatment reshaped gut microbiota imbalance caused HFFD. Specifically, compared model group, lower abundances Faecalibaculum (by 95.11%), Ruminococcus_torques_group 208.14%), Clostridium_sensu_stricto_1 449.37%), Ileibacterium 172.64%), while higher Verrucomicrobia Akkermansia 425.0%) observed high-UroA-producing group (p < 0.05). This study provided new insights into EA's anti-NAFLD effectiveness suggested response capacity greatly determined performance alleviating development NAFLD.

Language: Английский

---

Identification of key genes involved in the alleviative effects of Polysaccharide of Atractylodes macrocephala Koidz on high-fat diet-induced nonalcoholic fatty liver disease in mice

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 116, P. 106201 - 106201

Published: April 23, 2024

Non-alcoholic fatty liver disease (NAFLD) is increasingly prevalent, but treatment options are limited. Previous studies have demonstrated the hepatoprotective effects of Polysaccharide Atractylodes macrocephala Koidz (PAMK) against injury induced by various causes, its potential in alleviating NAFLD remains unknown. This study aimed to investigate PAMK improving and regulatory on gene transcription during process. The results indicated that Highfatdiet (HFD) could induce mice, was found alleviate symptoms mitigate caused HFD. Transcriptome analysis revealed affects both metabolic inflammatory pathways, suggesting dual impact maintaining homeostasis suppressing inflammation progression. biochemical markers, key genes cholesterol pathway, glucose (GLU), factors further role metabolism inflammation.

Language: Английский

---

Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113154 - 113154

Published: Sept. 14, 2024

Language: Английский

---

DHA-enriched phosphatidylserine alleviates bisphenol A-induced liver injury through regulating glycerophospholipid metabolism and the SIRT1-AMPK pathway

Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34835 - e34835

Published: July 1, 2024

To investigate the alleviating effect and mechanism of docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) on bisphenol A (BPA)-induced liver injury in mice, murine model was established by gavage BPA (5 mg/kg) or co-administration DHA-PS (50 mg/kg 100 for 6 weeks. The results showed that after administration DHA-PS, index, serum levels AST, ALT, TC, TG, NEFA, LDL-C mice were significantly decreased, while HDL-C increased. LPS, IL-6, IL-1β, TNF-α, MDA tissues effectively down-regulated, IL-10, SOD, GSH-Px, CAT up-regulated. H&E Oil Red O staining damage notably repaired lipid deposition reduced administration. Furthermore, metabolomics immunohistochemical studies revealed mainly regulates glycerophospholipid metabolism SIRT1-AMPK pathway to improve metabolic disorders caused BPA. Therefore, could potentially alleviate BPA-induced through suppressing inflammation oxidative stress, modulating disorders.

Language: Английский

---