Protective role of 2-aminothiazole derivative against ethanol-induced teratogenic effects in-vivo zebrafish DOI

S Madesh,

Gokul Sudhakaran,

Karthikeyan Ramamurthy

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116601 - 116601

Published: Oct. 1, 2024

Language: Английский

Molecular Dynamics Simulation Reveals Structural Insights into Isozyme Selectivity of Carbonic Anhydrase XII Inhibitors in Hypoxic Tumor Microenvironment DOI
Venkatesan Saravanan, P. Sivashanmugam, Bharath Kumar Chagaleti

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 753, P. 151471 - 151471

Published: Feb. 11, 2025

Language: Английский

Citations

1
Combined effects of vitamin D3 and dioxopiperidinamide derivative on lipid homeostasis, inflammatory pathways, and redox imbalance in non‐alcoholic fatty liver disease in vivo zebrafish model DOI

Santhanam Sanjai Dharshan,

Karthikeyan Ramamurthy,

S. Kaliraj

et al.

Biotechnology and Applied Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract Liver damage and metabolic dysfunctions, the defining features of non‐alcoholic fatty liver disease (NAFLD), are marked by inflammation, oxidative stress, excessive hepatic fat accumulation. The current therapeutic approaches for NAFLD limited, necessitating exploring novel treatment strategies. Dioxopiperidinamide derivatives, particularly DOPA‐33, have shown effective anti‐inflammatory antioxidant properties, potentially offering benefits against NAFLD. This study investigated combined potential vitamin D 3 (Vit ) DOPA‐33 in treating network pharmacology analysis identified key targets modulated Vit D3 emphasizing their mechanisms action. In NAFLD‐induced zebrafish models, significantly reduced lipid accumulation, apoptosis, demonstrating superior efficacy over individual treatments. also lowered reactive oxygen species (ROS) levels, decreased damage, enhanced defense mechanisms. Moreover, behavioral analyses showed improved locomotion weight gain treated zebrafish. Biochemical revealed lower triglycerides (TG) glucose levels with markers. Furthermore, histological indicated steatosis expression lipogenesis‐related genes inflammatory mediators. Finally, high‐performance liquid chromatography (HPLC) confirmed a significant reduction cholesterol indicating effectiveness combination therapy addressing NAFLD‐related dyslipidemias. These findings suggest that + pathways involved metabolism, stress promising approach

Language: Английский

Citations

7
Rational design of some 1,3,4 trisubstituted pyrazole-thiazole derivatives to serve as MtInhA inhibitors using QSAR, ADMET, Molecular Docking, MM-GBSA, and Molecular Dynamics Simulations approach DOI Creative Commons

Neha M. Mhetre,

Aniket L. Bhatambrekar,

D. Priya

et al.

Chemical Physics Impact, Journal Year: 2024, Volume and Issue: 9, P. 100769 - 100769

Published: Nov. 3, 2024

Language: Английский

Citations

5
Chalcone derivative enhance poultry meat preservation through quorum sensing inhibition against Salmonella (Salmonella enterica serovar Typhi) contamination DOI
S.P. Ramya Ranjan Nayak,

Pratik Pohokar,

Anamika Das

et al.

Food Control, Journal Year: 2025, Volume and Issue: unknown, P. 111155 - 111155

Published: Jan. 1, 2025

Citations

0
Exposure to bisphenol A and sodium nitrate found in processed meat induces endocrine disruption and dyslipidemia through PI3K/AKT/SREBP pathway in zebrafish larvae DOI
S.P. Ramya Ranjan Nayak, Anamika Das,

Karthikeyan Ramamurthy

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109887 - 109887

Published: Feb. 1, 2025

Language: Английский

Citations

0
Investigating the genomic and biochemical effects of dalapon on antioxidant systems in zebrafish, Danio rerio DOI
Mehtap Bayır, Abdulkadir Bayır, Burcu Naz Uzun

et al.

Toxicology Mechanisms and Methods, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: March 12, 2025

This research explored the effects of dalapon exposure on expression various genes, including cat, sod1, sod2, sod3a, sod3b, gpx1a, gpx3, gpx4a, gpx4b, gpx7, gpx8, gpx9, gstr, g6pd, and gsr, along with activities related antioxidant enzymes (AEs), such as CAT, SOD, GPX, G6PD, GST, GR in zebrafish. Kidney liver tissues were analyzed to assess oxidative stress levels. Results indicated that both concentration (25 50 ppm) duration had a significant effect AE gene expression. RT-PCR analysis suggested changes among dalapon-exposed zebrafish might indicate rapid response pesticide-induced stress. Moreover, GST increased at specified concentrations. In contrast, prolonged exceeding 72 h led significantly higher malondialdehyde levels kidney compared control group. These findings enhance our understanding role provide important insights for developing aquaculture breeding programs focused improving fish tolerance. Furthermore, phylogenetic conserved synteny confirmed enzyme genes are orthologous those found other model organisms, medaka stickleback. Consequently, these results could be beneficial vertebrate species.

Language: Английский

Citations

0
Comparative in-silico study on the antimalarial, anti-HIV, and diuretic properties of a series of substituted bis-2-hydroxy-1,4-naphthoquinone derivatives DOI Creative Commons
Siuli Sen, Koushik Nandan Dutta,

Malita Sarma Borthakur

et al.

Discover Chemistry., Journal Year: 2025, Volume and Issue: 2(1)

Published: March 20, 2025

Language: Английский

Citations

0
Nano‐Encapsulated Coumarin Derivative, CS‐QM2 Inhibits Neoplasm Growth: Experimented in Zebrafish Model DOI Open Access

S Madesh,

Raghul Murugan, A. C. SAU

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(4)

Published: March 27, 2025

Cancer remains a significant global health challenge with limited therapeutic success, prompting the need for innovative treatment strategies. This study investigates anticancer potential of nano-encapsulated metal derivatives (CS-QM2) using zebrafish model chemically induced cellular neoplasia. Characterization CS-QM2 nanoparticles revealed successful synthesis high entrapment efficiency and enhanced drug release under acidic conditions. Zebrafish embryos exposed to 7,12-Dimethylbenz[a]anthracene (DMBA) exhibited malformations, macrophage accumulation, abnormal tissue growth, which were markedly reduced by treatment. significantly increases intracellular ROS, resulting in higher LPO induces apoptosis neoplasm tissues. Furthermore, alters tumor microenvironment, reducing accumulation decreasing neutral lipid droplets, disrupting TAM metabolic support limiting their protumorigenic activities. Biochemical assays demonstrated restored activities antioxidant enzymes SOD, CAT, GSH. Gene expression analysis showed upregulation suppressor genes (cas3, p53) downregulation inflammatory (cox-2, nf-kb). Histological assessment SEM confirmed occurrence abnormalities. These findings suggest that effectively inhibit growth modulate microenvironment through oxidative stress induction gene regulation.

Language: Английский

Citations

0
Anti-inflammatory and antioxidative effects of Perilla frutescens-derived extracellular vesicles: Insights from Zebrafish models DOI

Jinghong Huang,

Linxin Chen, Wenhua Li

et al.

Molecular Immunology, Journal Year: 2025, Volume and Issue: 182, P. 126 - 138

Published: April 22, 2025

Language: Английский

Citations

0
Toxicity and therapeutic property of dioxopiperidin derivative SKT40 demonstrated in-vivo zebrafish model due to inflammatory bowel disease DOI

B Aswinanand,

S.P. Ramya Ranjan Nayak,

S Madesh

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2024, Volume and Issue: 284, P. 109990 - 109990

Published: July 30, 2024

Language: Английский

Citations

3