Molecular Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
19(6), P. 1687 - 1703
Published: Feb. 14, 2022
Self-assembly
of
amphiphilic
macromolecules
has
provided
an
advantageous
platform
to
address
significant
issues
in
a
variety
areas,
including
biology.
Such
soft
nanoparticles
with
hydrophobic
core
and
hydrophilic
corona,
referred
as
micelles,
have
been
extensively
investigated
for
delivering
lipophilic
therapeutics
by
physical
encapsulation.
Polymeric
vesicles
or
polymersomes
similarities
morphology
liposomes
continue
play
essential
role
understanding
the
behavior
cell
membranes
and,
addition,
offered
opportunities
designing
smart
nanoformulations.
With
evolution
synthetic
methodologies
macromolecular
precursors,
construction
such
assemblies
can
now
be
modulated
tailor
their
properties
match
desired
needs.
This
review
brings
into
focus
current
state-of-the-art
design
using
miktoarm
star
polymers
through
detailed
analysis
synthesis
tuned
lengths
varied
polymeric
arms,
self-assembly,
applications
drug
delivery.
Chemical Communications,
Journal Year:
2022,
Volume and Issue:
58(38), P. 5683 - 5716
Published: Jan. 1, 2022
Molecular
polymer
bottlebrushes
are
densely
grafted,
individual
macromolecules
with
nanoscale
proportions.
The
last
decade
has
seen
an
increased
focus
on
this
material
class,
especially
in
nanomedicine
and
for
biomedical
applications.
This
Feature
Article
provides
overview
of
major
developments
area
to
highlight
the
many
opportunities
that
these
architectures
bring
nano-bio
research.
article
covers
aspects
bottlebrush
synthesis
summarises
their
use
drug
gene
delivery,
imaging,
as
theranostics
prototype
materials
correlate
nanoparticle
structure
composition
biological
function
behaviour.
Areas
future
research
discussed.
ACS Applied Polymer Materials,
Journal Year:
2023,
Volume and Issue:
6(1), P. 1 - 27
Published: Nov. 30, 2023
Biofouling
caused
by
nonspecific
adsorption
of
biomolecules
and
organisms
such
as
proteins,
cells,
bacteria
to
material
surfaces
is
a
significant
challenge
for
numerous
important
applications.
An
effective
approach
addressing
this
problem
coat
antifouling
polymers
on
the
impart
demanded
properties
repel
biological
adhesion.
In
review,
we
summarized
recent
advances
in
surface
polymer
brushes
which
have
emerged
past
decade,
with
focus
origin
brushes,
approaches
key
factors
that
impact
properties,
common
used
construction
applications
variety
fields.
Langmuir,
Journal Year:
2024,
Volume and Issue:
40(5), P. 2439 - 2464
Published: Jan. 27, 2024
For
over
two
decades,
polymer
brushes
have
found
wide
applications
in
industry
and
scientific
research.
Now,
brush
research
has
been
a
significant
focus
the
community
of
science.
In
this
review
paper,
we
give
an
introduction
to
synthesis,
self-assembly,
one-dimensional
(1D)
on
backbones,
two-dimensional
(2D)
flat
surfaces,
three-dimensional
(3D)
spherical
particles.
Examples
synthesis
different
substrates
are
provided.
Studies
formation
surface
nanostructures
solid
surfaces
also
reviewed
article.
Multicomponent
able
self-assemble
into
micelles
(s-micelles).
If
s-micelles
linked
through
cleavable
linkages,
can
be
cleaved
from
substrates,
hierarchical
structures.
The
by
coassembly
"free"
chains
(coassembly
approach)
or
polymerization-induced
self-assembly
approach,
is
discussed.
colloid
biomedical
science
summarized.
Finally,
perspectives
development
offered
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(10), P. 6796 - 6805
Published: Feb. 29, 2024
Block
polymer
self-assembly
affords
a
versatile
bottom-up
strategy
to
develop
materials
with
the
desired
properties
dictated
by
specific
symmetries
and
dimensions.
Owing
distinct
compared
linear
counterparts,
bottlebrush
block
polymers
side
chains
densely
grafted
on
backbone
have
attracted
extensive
attention.
However,
morphologies
found
in
so
far
are
limited,
only
lamellar
cylindrical
ordered
phases
been
reported
diblock
bottlebrushes.
The
absence
of
complex
morphologies,
such
as
networks,
might
originate
from
intrinsically
stiff
architecture.
We
experimentally
investigated
nonfrustrated
ABC
terpolymers,
based
two
chemistries,
poly(ethylene-alt-propylene)-b-polystyrene-b-poly(dl-lactic
acid)
(PEP-PS-PLA)
PEP-b-PS-b-poly(ethylene
oxide)
(PEP-PS-PEO),
synthesized
ring-opening
metathesis
polymerization
norbornene-terminated
macromonomers.
Structural
characterization
small-angle
X-ray
scattering
transmission
electron
microscopy
measurements
revealed
an
unprecedented
cylinders-in-undulating-lamellae
(CUL)
morphology
p2
symmetry
for
both
systems.
Additionally,
automated
liquid
chromatography
was
employed
fractionate
PEP-PS-PLA
polymer,
leading
fractions
spectrum
including
CUL.
These
findings
underscore
significance
macromolecular
dispersity
nominally
narrow
while
demonstrating
power
this
fractionation
technique.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(25)
Published: March 29, 2024
Abstract
Bottlebrush
polymers
(BB)
have
emerged
as
compelling
candidates
for
biosystems
to
face
tribological
challenges,
including
friction
and
wear.
This
study
provides
a
comprehensive
assessment
of
an
engineered
triblock
BB
polymer's
affinity,
cell
toxicity,
lubrication,
wear
protection
in
both
vitro
vivo
settings,
focusing
on
applications
conditions
like
osteoarthritis
dry
eye
syndrome.
Results
show
that
the
designed
polymer
rapidly
adheres
various
surfaces
(e.g.,
cartilage,
eye,
contact
lens),
forming
robust,
biocompatible
layer
surface
lubrication
protection.
The
performance
biocompatibility
are
further
enhanced
presence
hyaluronic
acid
(HA)
vivo.
exceptional
favorable
interaction
with
HA
position
synthesized
promising
candidate
innovative
treatments
addressing
deficiencies
bio‐lubricant
systems.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(24)
Published: April 8, 2024
Abstract
Environmentally
friendly
crosslinked
polymer
networks
feature
degradable
covalent
or
non‐covalent
bonds,
with
many
of
them
manifesting
dynamic
characteristics.
These
attributes
enable
convenient
degradation,
facile
reprocessibility,
and
self‐healing
capabilities.
However,
the
inherent
instability
these
crosslinking
bonds
often
compromises
mechanical
properties
networks,
limiting
their
practical
applications.
In
this
context,
environmentally
dual‐crosslinking
(denoted
EF‐DCPNs)
have
emerged
as
promising
alternatives
to
address
challenge.
materials
effectively
balance
need
for
high
ability
degrade,
recycle,
and/or
self‐heal.
Despite
potential,
investigations
into
EF‐DCPNs
remain
in
nascent
stages,
several
gaps
limitations
persist.
This
Review
provides
a
comprehensive
overview
synthesis,
properties,
applications
recent
progress
EF‐DCPNs.
Firstly,
synthetic
routes
rich
variety
possessing
two
distinct
types
(i.e.,
imine,
disulfide,
ester,
hydrogen
bond,
coordination
other
bonds)
are
introduced.
Subsequently,
complex
structure‐
nature‐dependent
mechanical,
thermal,
electrical
discussed,
followed
by
exemplary
electronics
biotechnology.
Finally,
future
research
directions
rapidly
evolving
field
outlined.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(34), P. 24094 - 24104
Published: Aug. 14, 2024
Anisotropic
nanoparticles
such
as
worm-like
micelles
have
aroused
much
attention
due
to
their
promising
applications
from
templates
drug
delivery.
The
fabrication
of
with
tunable
structural
stability
and
control
over
diameter
length
is
great
importance
but
still
challenging.
Herein,
we
report
a
kinetically
controlled
ring-opening
metathesis
polymerization-induced
self-assembly
(ROMPISA)
for
the
robust
preparation
trapped
diameter/length
at
enlarged
experimental
windows
by
rational
manipulation
kinetic
factors,
including
solvent
property,
temperature,
π-π
stacking
effects.
resultant
worm
structures
were
thermodynamically
metastable
capable
excellent
room
temperature
trapping
effect.
At
elevated
temperatures,
these
worms
could
undergo
morphology
evolution
into
vesicular
in
manner.
Moreover,
also
be
significantly
enhanced
situ
cross-linking.
Overall,
this
ROMPISA
opens
new
avenue
PISA
chemistry
that
expected
prepare
"smart"
polymer
materials
manipulating
factors.
Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
The
shape
transformation
of
polymer
vesicles
is
great
importance
for
biorelevant
applications
as
well
understanding
cellular
adaptation.
However,
realizing
in
a
controlled
manner
by
rationally
manipulating
the
molecular
geometry
building
block
still
challenging.
Herein,
we
reported
contraction
process
individual
via
realignment
bottlebrush
segments
using
linear-alt-bottlebrush
alternating
multiblock
copolymer
(LBAMBCP)
block.
well-defined
LBAMBCPs,
A50[(xbB)mA50]n
(x
=
1
and
3
refer
to
grafting
density,
m
10,
20,
30,
n
1,
3,
5),
that
consisted
xbB
segment
with
varied
densities
(x)
PS
branches
A
linear
poly[norbornene-oligopoly(ethylene
glycol)]
(poly(NB-OEG))
were
first
synthesized.
To
perform
self-assembly
selective
solvent
poly(NB-OEG)
segments,
found
these
LBAMBCPs
high
density
3)
promoted
formation
vesicular
structures,
typical
hollow
an
average
size
over
600
nm
produced.
It
was
observed
formed
7-
11-LBAMBCPs
A50[(3bB)10A50]n
(n
5)
could
further
undergo
evolve
into
compound
steady
reduction
vesicle
wall.
confirmed
be
strongly
related
number
simply
regulated
changing
initial
concentration
composition.
Overall,
provide
fresh
case
blocks.
