Anisotropy in Antimicrobial Bottle Brush Copolymers and Its Influence on Biological Activity DOI Creative Commons
Anne‐Catherine Lehnen, Sergio Kogikoski, Till Stensitzki

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(10)

Published: Nov. 30, 2023

Abstract Antimicrobial polymers are a promising alternative to conventional antibiotics in the fight against antimicrobial resistance. Cationic bottle brush copolymers have shown be superior linear topologies previous studies. Herein, aspect ratio of such is varied creating differently shaped confined unimolecular structures with varying degrees side chain mobility. Using reversible addition‐fragmentation chain‐transfer (RAFT) polymerization, brushes produced one‐pot procedure. The morphology confirmed by atomic force microscopy. hydrophobicity, as determined via high performance‐liquid chromatography (HPLC) analysis, drastically influenced topology. Fourier‐transform infrared (FTIR) spectroscopy, it found that mobility and increased global hydrophilicity, less hydrated, stronger intramolecular hydrogen bonds. A phase segregated leading micellization assumed. Biological tests reveal activity for polymers. Their excellent hemocompatibility results highly selective whose adaptability seems key feature their performance. This study highlights tremendous importance structural control

Language: Английский

Effects of cores types on non-solvent displacement nonaqueous precipitation synthesis of core-shell structured materials: A case study on effects of carbon sources on C@ZrSiO4 preparation DOI
Guo Feng, Weifeng Xie, Feng Jiang

et al.

Ceramics International, Journal Year: 2024, Volume and Issue: 50(11), P. 18370 - 18379

Published: Feb. 27, 2024

Language: Английский

Citations

47
Nanoscale polymer discs, toroids and platelets: a survey of their syntheses and potential applications DOI

Emma R. L. Brisson,

Max J. H. Worthington, Simran Kerai

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(4), P. 1984 - 2021

Published: Jan. 1, 2024

In this review, we focus on nanoscale polymer discs, toroids, and platelets. We illustrate design rules, group compositions discuss commonly used self-assembly strategies. summarise look ahead to potential applications of these nanomaterials.

Language: Английский

Citations

18
Multiarm-Assisted Design of Dendron-like Degradable Ionizable Lipids Facilitates Systemic mRNA Delivery to the Spleen DOI
Lulu Xue,

Xinhong Xiong,

Gan Zhao

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Lipid nanoparticles (LNPs) have emerged as pivotal vehicles for messenger RNA (mRNA) delivery to hepatocytes upon systemic administration and antigen-presenting cells following intramuscular injection. However, achieving mRNA non-hepatocytes remains challenging without the incorporation of targeting ligands such antibodies, peptides, or small molecules. Inspired by comb-like polymeric architecture, here we utilized a multiarm-assisted design construct library 270 dendron-like degradable ionizable lipids altering structures amine heads multiarmed tails optimal delivery. Following in vitro high-throughput screening, series top-dendron-like LNPs with high transfection efficacy were identified. These facilitated greater spleen vivo compared lipid analogs lacking structure. Proteomic analysis corona-LNP pellets showed enhancement key protein clusters, suggesting potential endogenous spleen. A lead LNP formulation, 18-2-9b2, was further used encapsulate Cre demonstrated excellent genome modification splenic macrophages, outperforming spleen-tropic MC3/18PA Ai14 mice model. Moreover, 18-2-9b2 encapsulating therapeutic BTB domain CNC homologue 1 (BACH1) exhibited proficient BACH1 expression subsequent Spic downregulation red pulp macrophages (RPM) Spic-GFP transgene model intravenous administration. results underscore facilitatem potentially opening avenues range mRNA-LNP applications, including regenerative medicine, replacement, gene editing therapies.

Language: Английский

Citations

3
Nanoscale Surface Topography of Polyethylene Glycol-Coated Nanoparticles Composed of Bottlebrush Block Copolymers Prolongs Systemic Circulation and Enhances Tumor Uptake DOI
Julian Grundler, Kwangsoo Shin,

Hee‐Won Suh

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 2815 - 2827

Published: Jan. 16, 2024

Improving the performance of nanocarriers remains a major challenge in clinical translation nanomedicine. Efforts to optimize nanoparticle formulations typically rely on tuning surface density and thickness stealthy polymer coatings, such as poly(ethylene glycol) (PEG). Here, we show that modulating topography PEGylated nanoparticles using bottlebrush block copolymers (BBCPs) significantly enhances circulation tumor accumulation, providing an alternative strategy improve coatings. Specifically, with rough achieve high cell uptake vivo due superior extravasation distribution compared conventional smooth-surfaced based linear copolymers. Furthermore, profoundly impacts interaction serum proteins, resulting adsorption fundamentally different proteins onto rough-surfaced formed from BBCPs. We envision controlling will enable design improved various biomedical applications.

Language: Английский

Citations

15
AI Empowering Traditional Chinese Medicine? DOI Creative Commons

Zhilin Song,

Guanxing Chen, Calvin Yu‐Chian Chen

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

AI-powered analysis of TCM chemical data enhances component identification, drug discovery, personalized treatment, and pharmacological action elucidation, driving the modernization sustainable development TCM.

Language: Английский

Citations

8
Recent advances in formulation and application of molecular polymer brushes in biomedicine: Therapeutic, diagnostic, and theranostics capabilities DOI

Floria Adeli,

Farhang Abbasi, Parisa Ghandforoushan

et al.

Nano Today, Journal Year: 2023, Volume and Issue: 53, P. 102010 - 102010

Published: Oct. 9, 2023

Language: Английский

Citations

15
An organometallic swap strategy for bottlebrush polymer–protein conjugate synthesis DOI Creative Commons
Bin Liu, Jacob Rodriguez, Landon J. Kilgallon

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(31), P. 4238 - 4241

Published: Jan. 1, 2024

Conjugates of proteins and bottlebrush polymers are prepared using an “organometallic swap” strategy.

Language: Английский

Citations

6
Monomer Emulsified Aqueous Ring-Opening Metathesis Polymerization (ME-ROMP) for the Synthesis of Water-Soluble Molecular Bottlebrushes with a Precise Structure DOI
Wangmeng Hou,

Yingqing Zhou,

Xiuzhe Yin

et al.

Macromolecules, Journal Year: 2023, Volume and Issue: 56(19), P. 7889 - 7897

Published: Aug. 21, 2023

Water-soluble molecular bottlebrushes (MBBs) with various functions and tunable morphologies have found promising application prospects in the biorelevant field. However, facile synthesis of water-soluble MBBs well-defined architectures is challenging by different chemistry. Herein, we explore versatility monomer emulsified aqueous ring-opening metathesis polymerization (ME-ROMP) for via a grafting-through strategy. The ME-ROMP was carried out injecting tiny amount Grubbs' third-generation catalyst (G3) solution CH2Cl2 into norbornene macromonomers (NB MMs) without deoxygenation, forming NB MMs-stabilized CH2Cl2/H2O emulsions. In this ME-ROMP, moieties G3 are concentrated droplets so that decomposition could be significantly suppressed steric hindrance MMs reduced, leading to an accelerated polymerization. results demonstrate living ultrafast rates near quantitative initiation conversion, producing diverse compositions contour lengths.

Language: Английский

Citations

10
Amphiphilic Heterografted Molecular Bottlebrushes with Tertiary Amine‐Containing Side Chains as Efficient and Robust pH‐Responsive Emulsifiers DOI Creative Commons

Michael T. Kelly,

Zhan Chen, Thomas P. Russell

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(52)

Published: Nov. 13, 2023

By combining the unique characteristics of molecular bottlebrushes (MBBs) and properties stimuli-responsive polymers, we show that MBBs with randomly grafted poly(n-butyl acrylate) pH-responsive poly(2-(N,N-diethylamino)ethyl methacrylate) (PDEAEMA) side chains are efficient robust emulsifiers. Water-in-toluene emulsions were formed at pH 4.0 disrupted by increasing to 10.0. The emulsion generation disruption was reversible over ten cycles investigated, remained intact. exceptional stability stemmed from high interfacial binding energy MBBs, imparted their large size Janus architecture interface, as evidenced jamming wrinkling assemblies upon reducing area. At 10.0, PDEAEMA became water-insoluble, desorbed causing de-emulsification. Consequently, have shown judicious design can generate particle emulsifiers size, while responsiveness enables more potential applications.

Language: Английский

Citations

10
Synthesis of Dendronized Polymers via a “m+n” Grafting‐onto Strategy with Reaction‐Enhanced Reactivity of Intermediates (RERI) Mechanism DOI Open Access

Yingqing Zhou,

Yanping Xu,

Xiuzhe Yin

et al.

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Comprehensive Summary Dendronized polymers (DenPols) with tunable shape and surface property have been recognized as a type of promising unimolecular nanomaterials. However, it still has lacked rapid efficient approach to the facile synthesis DenPols high‐generation well‐defined structures. Herein, we report “ m+n” grafting‐onto strategy combined copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) reaction reaction‐enhanced reactivity intermediates (RERI) mechanism for synthesizing G m + n by attaching ‐generation dendrons (G ) onto . In this m+n ” strategy, ( = 1, 2) bearing 1,3‐triazido branches on repeating unit were capable RERI effect that guaranteed CuAAC in an extremely way ultrafast kinetics synthesize third‐, fourth‐ fifth‐generation 1+2 , 1+3 1+4 2+2 2+3 near quantitative grafting density narrow distribution. Moreover, these resultant had more terminal groups per due three structure, exhibiting valuable potential opportunities molecular engineering. The development not only presents new avenue preparing but also holds great promise materials functional groups.

Language: Английский

Citations

0