Loop to linear: exploring the impact of corona topology on the properties of self-assembled polymer nanoparticles DOI
Haoxiang Zeng,

Markus Müllner

Polymer Chemistry, Journal Year: 2024, Volume and Issue: 15(16), P. 1648 - 1659

Published: Jan. 1, 2024

Cyclic block copolymers with photo-cleavable linkers were prepared, allowing looped-to-linear corona transformations via UV-induced post-assembly modification, and showcasing their versatility as topology-tuned drug delivery systems.

Language: Английский

Effects of cores types on non-solvent displacement nonaqueous precipitation synthesis of core-shell structured materials: A case study on effects of carbon sources on C@ZrSiO4 preparation DOI
Guo Feng, Weifeng Xie, Feng Jiang

et al.

Ceramics International, Journal Year: 2024, Volume and Issue: 50(11), P. 18370 - 18379

Published: Feb. 27, 2024

Language: Английский

Citations

47
Nanoscale polymer discs, toroids and platelets: a survey of their syntheses and potential applications DOI

Emma R. L. Brisson,

Max J. H. Worthington, Simran Kerai

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(4), P. 1984 - 2021

Published: Jan. 1, 2024

In this review, we focus on nanoscale polymer discs, toroids, and platelets. We illustrate design rules, group compositions discuss commonly used self-assembly strategies. summarise look ahead to potential applications of these nanomaterials.

Language: Английский

Citations

17
Multiarm-Assisted Design of Dendron-like Degradable Ionizable Lipids Facilitates Systemic mRNA Delivery to the Spleen DOI
Lulu Xue,

Xinhong Xiong,

Gan Zhao

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Lipid nanoparticles (LNPs) have emerged as pivotal vehicles for messenger RNA (mRNA) delivery to hepatocytes upon systemic administration and antigen-presenting cells following intramuscular injection. However, achieving mRNA non-hepatocytes remains challenging without the incorporation of targeting ligands such antibodies, peptides, or small molecules. Inspired by comb-like polymeric architecture, here we utilized a multiarm-assisted design construct library 270 dendron-like degradable ionizable lipids altering structures amine heads multiarmed tails optimal delivery. Following in vitro high-throughput screening, series top-dendron-like LNPs with high transfection efficacy were identified. These facilitated greater spleen vivo compared lipid analogs lacking structure. Proteomic analysis corona-LNP pellets showed enhancement key protein clusters, suggesting potential endogenous spleen. A lead LNP formulation, 18-2-9b2, was further used encapsulate Cre demonstrated excellent genome modification splenic macrophages, outperforming spleen-tropic MC3/18PA Ai14 mice model. Moreover, 18-2-9b2 encapsulating therapeutic BTB domain CNC homologue 1 (BACH1) exhibited proficient BACH1 expression subsequent Spic downregulation red pulp macrophages (RPM) Spic-GFP transgene model intravenous administration. results underscore facilitatem potentially opening avenues range mRNA-LNP applications, including regenerative medicine, replacement, gene editing therapies.

Language: Английский

Citations

3
Nanoscale Surface Topography of Polyethylene Glycol-Coated Nanoparticles Composed of Bottlebrush Block Copolymers Prolongs Systemic Circulation and Enhances Tumor Uptake DOI
Julian Grundler, Kwangsoo Shin,

Hee‐Won Suh

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 2815 - 2827

Published: Jan. 16, 2024

Improving the performance of nanocarriers remains a major challenge in clinical translation nanomedicine. Efforts to optimize nanoparticle formulations typically rely on tuning surface density and thickness stealthy polymer coatings, such as poly(ethylene glycol) (PEG). Here, we show that modulating topography PEGylated nanoparticles using bottlebrush block copolymers (BBCPs) significantly enhances circulation tumor accumulation, providing an alternative strategy improve coatings. Specifically, with rough achieve high cell uptake vivo due superior extravasation distribution compared conventional smooth-surfaced based linear copolymers. Furthermore, profoundly impacts interaction serum proteins, resulting adsorption fundamentally different proteins onto rough-surfaced formed from BBCPs. We envision controlling will enable design improved various biomedical applications.

Language: Английский

Citations

13
An organometallic swap strategy for bottlebrush polymer–protein conjugate synthesis DOI Creative Commons
Bin Liu, Jacob Rodriguez, Landon J. Kilgallon

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(31), P. 4238 - 4241

Published: Jan. 1, 2024

Conjugates of proteins and bottlebrush polymers are prepared using an “organometallic swap” strategy.

Language: Английский

Citations

6
AI Empowering Traditional Chinese Medicine? DOI Creative Commons

Zhilin Song,

Guanxing Chen, Calvin Yu‐Chian Chen

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

AI-powered analysis of TCM chemical data enhances component identification, drug discovery, personalized treatment, and pharmacological action elucidation, driving the modernization sustainable development TCM.

Language: Английский

Citations

6
Recent advances in formulation and application of molecular polymer brushes in biomedicine: Therapeutic, diagnostic, and theranostics capabilities DOI

Floria Adeli,

Farhang Abbasi, Parisa Ghandforoushan

et al.

Nano Today, Journal Year: 2023, Volume and Issue: 53, P. 102010 - 102010

Published: Oct. 9, 2023

Language: Английский

Citations

13
Synthesis of Dendronized Polymers via a “m+n” Grafting‐onto Strategy with Reaction‐Enhanced Reactivity of Intermediates (RERI) Mechanism DOI Open Access

Yingqing Zhou,

Yanping Xu,

Xiuzhe Yin

et al.

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Comprehensive Summary Dendronized polymers (DenPols) with tunable shape and surface property have been recognized as a type of promising unimolecular nanomaterials. However, it still has lacked rapid efficient approach to the facile synthesis DenPols high‐generation well‐defined structures. Herein, we report “ m+n” grafting‐onto strategy combined copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) reaction reaction‐enhanced reactivity intermediates (RERI) mechanism for synthesizing G m + n by attaching ‐generation dendrons (G ) onto . In this m+n ” strategy, ( = 1, 2) bearing 1,3‐triazido branches on repeating unit were capable RERI effect that guaranteed CuAAC in an extremely way ultrafast kinetics synthesize third‐, fourth‐ fifth‐generation 1+2 , 1+3 1+4 2+2 2+3 near quantitative grafting density narrow distribution. Moreover, these resultant had more terminal groups per due three structure, exhibiting valuable potential opportunities molecular engineering. The development not only presents new avenue preparing but also holds great promise materials functional groups.

Language: Английский

Citations

0
Helical Polymer‐Containing Bottlebrush Polymers (BBPs): Design, Synthesis, and Perspectives DOI Open Access
Hui Zou,

Shiqi Wang,

C. D. Han

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Helical polymer‐containing bottlebrush polymers (BBPs) are a special and fascinating type of polymer. They possess topology contain helical as main chains (MCs) or side (SCs), thereby presenting interesting fantastic properties, such chiral amplification, circularly polarized luminescence, photonic crystal, so on. This review mainly focuses on BBPs containing polypeptides, polyacetylenes (PAs), polyisocyanides (PIs). Detailed summarizations severally given to with polypeptides MCs SCs. Meanwhile, comprising PAs fully discussed. What's more, consisted PIs SCs described separately. In addition, other briefly introduced, too. The authors hope this will motivate more interest in developing complex topologies encourage further progress functional materials.

Language: Английский

Citations

0
pH-Responsive Shape-Changing Molecular Bottlebrush Emulsifier DOI
Bin Zhao,

Michael T. Kelly,

Sachini H. Dayarathne

et al.

Macromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

Citations

0