Innate Immunity,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Background
Globally,
colorectal
cancer
(CRC)
is
among
the
most
prevalent
malignant
tumors.
It
characterized
by
unlimited
proliferation,
invasion,
and
metastasis.
MicroRNA-126
(miR-126)
has
been
shown
in
many
studies
to
play
a
significant
role
CRC,
but
data
regarding
its
CRC
Egyptian
patients
are
limited.
Objectives
This
case-control
study
aimed
investigate
miR-126
as
potential
marker
correlate
expression
levels
with
tumor,
node,
metastasis
(TNM)
stage,
distant
metastasis,
tumor
size.
Methods
The
included
50
adult
participants
(30
10
adenoma
pathological
control,
healthy
controls).
MiR-126
were
detected
using
Real-Time
Quantitative
PCR
(qPCR)
along
endogenous
reference
gene
hsa-miR-103a
all
participants.
Results
was
significantly
decreased
than
both
control
groups.
associated
advanced
TNM
stage
(
p
=
0.001)
0.002).
However,
it
not
correlated
size
0.980),
carcinoembryonic
antigen
(CEA)
0.397),
19-9
(CA19-9)
0.236).
best
cut-off
point
of
discriminate
from
controls
0.7
metastatic
non-metastatic
0.3.
Conclusions
Our
results
suggest
that
could
be
used
an
early
for
detection
good
prognostic
indicator
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(10)
Published: Oct. 17, 2024
MicroRNAs,
including
the
tumor-suppressor
miR-126
and
oncogene
miR-221,
regulate
tumor
formation
growth
in
colitis-associated
cancer
(CAC)
colorectal
(CRC).
This
study
explores
impact
of
epithelial
cytokine
heparin-binding
epidermal
factor
(HB-EGF)
its
receptor
(EGFR)
on
pathogenesis
CAC
CRC,
particularly
regulation
microRNA-driven
protease
expression.
In
murine
models
CRC
CAC,
lack
elevated
miR-221
expression
colonic
tissues
enhanced
growth.
MiR-126
downregulation
colon
cells
established
a
pro-tumorigenic
proteolytic
niche
by
targeting
HB-EGF-active
metalloproteinase-7,
-9
(MMP7/MMP9),
disintegrin,
metalloproteinase
domain-containing
protein
9,
modulating
chemokine-mediated
recruitment
HB-EGF-loaded
inflammatory
cells.
Mechanistically,
HB-EGF
EGFR
suppressed
via
activating
enhancer-binding
2
alpha.
Reintroducing
reduced
development
Combining
reintroduction,
which
targets
specific
proteases
but
not
ADAM17,
with
MMP
inhibitors
like
Batimastat
or
Marimastat
effectively
combination
normalized
balanced
levels
developing
growing
tumors.
These
findings
demonstrate
that
suppressing
EGFR1
shifts
balance
from
oncogenic
to
tumor-suppressive
action.
Consequently,
normalizing
could
open
new
avenues
for
treating
patients
this
normalization
is
intertwined
anticancer
efficacy
inhibitors.
Cancers,
Journal Year:
2024,
Volume and Issue:
17(1), P. 26 - 26
Published: Dec. 25, 2024
Prostate
pathologies,
including
chronic
prostatitis,
benign
prostatic
hyperplasia
(BPH),
and
prostate
cancer
(PCa),
are
strongly
associated
with
inflammation,
which
is
a
key
risk
factor
hallmark
of
these
diseases
[...]
ACS Omega,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 26, 2024
MicroRNAs
(miRNAs)
have
been
regarded
as
potential
biomarkers
in
evaluating
various
diseases,
such
pregnancy-induced
hypertension
and
cancers.
However,
sensitive
reliable
miRNA
detection
is
still
a
challenge
due
to
the
low
amplification
efficiency
high
background
signal.
Herein,
we
developed
colorimetric
method
for
utilizing
self-priming-initiated
color
reaction
loaded
on
rolling
circle
(RCA)
product.
In
this
method,
biotin-labeled
RCA
product
fixed
surface
of
streptavidin-coated
wells,
interfering
components
samples
are
removed
avoid
false
reactions,
thus
reducing
signals.
Two
signal
processes,
including
chain
extension,
endow
with
sensitivity
limit
at
10
fM
level.
conclusion,
our
approach
offers
promising
perspective
has
be
further
utilized
biomedical
research
early
cancer
detection.
Authorea (Authorea),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 24, 2024
Non-melanoma
skin
cancer
(NMSC)
encompasses
various
malignancies,
primarily
basal
cell
carcinoma
(BCC)
and
squamous
(SCC).
Extended
exposure
to
environmental
elements,
particularly
solar
ultraviolet
(UV)
radiation,
triggers
oxidative
stress
in
tissues,
resulting
DNA
damage
that
is
instrumental
the
initiation
progression
of
NMSC.
The
imbalance
between
pro-inflammatory
anti-inflammatory
cytokines
plays
a
significant
role
development
cancer.
Resveratrol
(RES),
an
organic
phytoalexin
present
grape
skins
seeds,
demonstrates
promising
chemopreventive
anti-neoplastic
capabilities
against
This
research
revealed
synergistic
lipid-nanocarrier
incorporating
RES
5-FU
showed
significantly
enhanced
effectiveness
curtailing
proliferation
malignant
cells,
notably
A431
line,
comparison
traditional
formulations.
Moreover,
study
illustrated
amalgamation
exerted
combined
effect
hindering
cellular
triggering
apoptosis
cancerous
as
evidenced
both
vitro
vivo
experiments.
Furthermore,
known
for
its
antioxidant
attributes,
which
may
alleviate
impact
ROS
triggered
by
UV
exposure,
thus
diminishing
impairment
mutations.
These
observations
imply
might
offer
benefits
NMSC
through
mitigating
stress.
offers
critical
insights
into
prospective
utility
safer,
more
effective
intervention
NMSC,
though
additional
investigations
are
required
thoroughly
decipher
underlying
molecular
mechanisms
clinical
implications.
Biology,
Journal Year:
2024,
Volume and Issue:
13(9), P. 734 - 734
Published: Sept. 19, 2024
Prostate
cancer
is
the
second
most
common
neoplasia
and
fifth-leading
cause
of
death
in
men
worldwide.
Electromagnetic
magnetic
fields
have
been
classified
as
possible
human
carcinogens,
but
current
understanding
molecular
cellular
pathways
involved
very
limited.
Effects
due
to
extremely
low
magnetic/hypomagnetic
(LMF)
are
furthermore
poorly
understood.
Extracellular
vesicles
(EVs)
crucial
mediators
communication
with
multifaceted
roles
progression,
including
via
transport
uptake
various
protein
microRNA
(miRNA)
EV-cargoes.
miRNAs
regulate
gene
expression
implicated
cancer-related
processes
such
proliferation,
metastasis,
chemoresistance.
This
study
investigated
effects
LMF
exposure
(20
nT)
by
shielding
on
prostate
cell
line
PC3
compared
epithelial
PNT2
under
short-term
(4
h)
conditions.
We
examined
EV
profiles
following
a
4
h
alongside
associated
functional
enrichment
KEGG
GO
for
proteomes.
The
significantly
reduced
release
modified
cargoes
more
inflammatory
metastatic
profile,
16
Disease
Pathways
95
Human
Phenotypes
specifically
LMF-treated
These
included
cancerous,
metabolic,
blood,
skin,
cardiac
skeletal
Pathways,
well
pain
developmental
disorders.
In
normal
cells,
less
cargo
was
observed
cells
not
exposed
LMF,
fewer
were
identified.
pointed
some
differences
functions,
ageing,
defence
responses,
oxidative
stress,
disease
phenotypes,
respiratory,
digestive,
immune,
pathways.
Furthermore,
we
analysed
alterations
matrix
metalloproteinases
(MMPs)
linked
this
aggressiveness.
caused
significant
increase
MMP2
MMP9,
onco-miRs
miR-155,
miR-210,
miR-21,
reduction
tumour-suppressor
miRs
(miR-200c
miR-126)
cells.
addition,
induced
invasion
Overall,
our
findings
suggest
that
changes
field
exposures
modulate
EV-mediated
miR-regulatory
PCa
providing
basis
exploring
novel
therapeutic
strategies.
Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
12(11), P. 8825 - 8845
Published: Oct. 24, 2024
ABSTRACT
Nonmelanoma
skin
cancer
(NMSC)
represents
the
most
prevalent
form
of
globally,
with
basal
cell
carcinoma
(BCC)
and
squamous
(SCC)
being
common
types.
The
search
for
effective
chemopreventive
therapeutic
agents
has
led
to
exploration
natural
compounds,
among
which
resveratrol
(RES),
a
polyphenolic
phytoalexin
found
in
grapes,
berries,
peanuts,
red
wine,
garnered
significant
attention.
This
comprehensive
review
aims
elucidate
effects
RES
on
NMSC,
focusing
its
mechanisms
action,
efficacy
preclinical
studies,
potential
as
agent.
exhibits
promising
antineoplastic
capabilities
against
NMSC
through
various
mechanisms,
including
induction
apoptosis,
inhibition
proliferation,
modulation
oxidative
stress,
anti‐inflammatory
activities.
Studies
have
demonstrated
that
can
significantly
enhance
effectiveness
traditional
chemotherapeutic
agents,
such
5‐fluorouracil
(5‐FU),
by
inhibiting
cellular
proliferation
inducing
apoptosis
cancerous
cells.
Furthermore,
resveratrol's
antioxidant
properties
may
mitigate
impact
reactive
oxygen
species
(ROS)
triggered
UV
exposure,
thus
reducing
DNA
damage
mutations
associated
development.
In
vitro
vivo
experiments
shown
effectively
hinder
growth
spread
tumor
types,
human
cutaneous
SCC
A431
cells,
induce
apoptosis.
development
advanced
delivery
systems,
nanostructured
lipid
carriers
liposomes,
been
recognized
their
RES,
particularly
anticancer
properties.
conclusion,
presents
viable
candidate
prevention
treatment
owing
multifaceted
ability
regulate
trigger
inhibit
proliferation.
However,
further
clinical
studies
are
required
fully
understand
safety
humans,
well
optimize
methods
improved
bioavailability
outcomes.
Innate Immunity,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Background
Globally,
colorectal
cancer
(CRC)
is
among
the
most
prevalent
malignant
tumors.
It
characterized
by
unlimited
proliferation,
invasion,
and
metastasis.
MicroRNA-126
(miR-126)
has
been
shown
in
many
studies
to
play
a
significant
role
CRC,
but
data
regarding
its
CRC
Egyptian
patients
are
limited.
Objectives
This
case-control
study
aimed
investigate
miR-126
as
potential
marker
correlate
expression
levels
with
tumor,
node,
metastasis
(TNM)
stage,
distant
metastasis,
tumor
size.
Methods
The
included
50
adult
participants
(30
10
adenoma
pathological
control,
healthy
controls).
MiR-126
were
detected
using
Real-Time
Quantitative
PCR
(qPCR)
along
endogenous
reference
gene
hsa-miR-103a
all
participants.
Results
was
significantly
decreased
than
both
control
groups.
associated
advanced
TNM
stage
(
p
=
0.001)
0.002).
However,
it
not
correlated
size
0.980),
carcinoembryonic
antigen
(CEA)
0.397),
19-9
(CA19-9)
0.236).
best
cut-off
point
of
discriminate
from
controls
0.7
metastatic
non-metastatic
0.3.
Conclusions
Our
results
suggest
that
could
be
used
an
early
for
detection
good
prognostic
indicator
