MicroRNA expression profile of alveolar epithelial cells infected with Aspergillus fumigatus DOI
Atiye Seda Yar Sağlam, Ayşe Kalkancı,

Duygu Deniz Usta Salimi

et al.

Journal of Applied Genetics, Journal Year: 2024, Volume and Issue: 65(3), P. 627 - 634

Published: May 10, 2024

Language: Английский

miRNAs as modulators of neuroinflammation and excitotoxicity: Implications for stroke therapeutics DOI
Mohammed S. Elballal, Osama A. Mohammed, Mohamed Bakr Zaki

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 253, P. 155093 - 155093

Published: Jan. 1, 2024

Language: Английский

Citations

6
The emerging role of miRNAs in myocardial infarction: From molecular signatures to therapeutic targets DOI
Osama A. Mohammed, Mushabab Alghamdi, Jaber Alfaifi

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 253, P. 155087 - 155087

Published: Jan. 1, 2024

Language: Английский

Citations

4
Connecting the Dots: How MicroRNAs Link Asthma and Atherosclerosis DOI Open Access

Răzvan-Ionuț Zimbru,

Elena-Larisa Zimbru,

Florina Bojin

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3570 - 3570

Published: April 10, 2025

Asthma and atherosclerosis are chronic conditions with distinct pathophysiologies, but overlapping inflammatory mechanisms that suggest a potential common regulatory framework. MicroRNAs (miRNAs), small non-coding RNA molecules modulate gene expression post-transcriptionally, could be key players in linking these disorders. This review outlines how miRNAs contribute to the complex interplay between asthma atherosclerosis, focusing on involved pathways, immune cell regulation vascular remodeling. We discuss specific miRNAs, such as miR-155, miR-21 miR-146a, which have been shown cytokine production T differentiation, impacting respiratory cardiovascular health. The found both emphasize their role biomarkers, also therapeutic targets. Understanding molecular connections may unlock novel approaches for innovative, integrated treatment strategies address significantly improve patient outcomes. Further research is needed explore mechanistic pathways validate translational of miRNA-based interventions preclinical clinical settings.

Language: Английский

Citations

0
Unveiling the regulatory role of miRNAs in stroke pathophysiology and diagnosis DOI
Mustafa Ahmed Abdel‐Reheim, Yousra Nomier, Mohamed Bakr Zaki

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 253, P. 155085 - 155085

Published: Jan. 1, 2024

Language: Английский

Citations

1
The potential role of miRNAs in the pathogenesis of schizophrenia – A focus on signaling pathways interplay DOI
Mohamed Bakr Zaki, Ahmed I. Abulsoud, Alaa Ashraf

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155102 - 155102

Published: Jan. 9, 2024

Language: Английский

Citations

1
The role of matrix metalloproteinase-2 and miR-196a2 in bronchial asthma pathogenesis and diagnosis DOI Creative Commons
Osama A. Mohammed, Ahmed S. Doghish, Mohannad Mohammad S. Alamri

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27694 - e27694

Published: March 1, 2024

BackgroundBronchial asthma is a persistent inflammatory respiratory condition that restricts the passage of air and causes hyperresponsiveness. Chronic can be classified into three categories: mild, moderate, severe. Remodeling took place as extracellular matrix accumulated in walls airways. Inflammation occurs result damage caused by metalloproteinase-2 (MMP-2) to basement membrane type IV collagen. The severity may associated with miR-196a2. objective our study was investigate underlying mechanisms clinical relevance miR-196a2 MMP-2 serum levels relation asthma.MethodsThis recruited 85 controls 95 asthmatics or Expression measured quantitative reverse transcriptase PCR. Using enzyme-linked immunosorbent assay (ELISA), MMP-2, IL-6, total immunoglobulin E (IgE) various grades were compared control group. MMP-2's diagnostic prognostic potential determined using ROC curve analysis. This also blood Eosinophils PFTs. We examined connections IgE, Eosinophils, PFTs.ResultsThe current investigation found expression significantly higher group than asthmatic patients whole. severe had IgE healthy controls. identified concentration cutoff great sensitivity specificity. Significant relationships between level patient found. considerably correlated positively eosinophils % negatively all lung function tests group.Conclusion: revealed elevated pathophysiology degree severity. have promising ability bronchial asthma.

Language: Английский

Citations

1
MicroRNA expression profile of alveolar epithelial cells infected with Aspergillus fumigatus DOI
Atiye Seda Yar Sağlam, Ayşe Kalkancı,

Duygu Deniz Usta Salimi

et al.

Journal of Applied Genetics, Journal Year: 2024, Volume and Issue: 65(3), P. 627 - 634

Published: May 10, 2024

Language: Английский

Citations

0