AIP conference proceedings, Journal Year: 2023, Volume and Issue: 2817, P. 020077 - 020077
Published: Jan. 1, 2023
Language: Английский
Veterinary Medicine International, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 8
Published: Nov. 22, 2022
Crocodile
oil
is
a
highly
effective
treatment
for
ailments
ranging
from
skin
conditions
to
cancer.
However,
the
effects
of
on
liver
detoxification
pathways
are
not
well
studied.
This
study
aimed
investigate
crocodile
enzyme
activities
and
mRNA
expressions
cytochrome
P450
1A2
(CYP1A2),
2E1
(CYP2E1),
glutathione
S-transferase
(GST)
in
rats.
The
rats
were
divided
into
four
groups
(n
=
7/group):
received
standard
diet
(C),
high-fat
or
HFD
(H),
with
1
ml
(HCO1)
3
(HCO3)
per
kg
body
weight.
Interestingly,
yields
this
presented
alpha-linolenic
acid
(0.96%)
at
similar
levels
compared
fish
oil.
results
revealed
that
significantly
increased
activity
relative
gene
expression
CYP1A2
H
group
(
Language: Английский
Citations
7
Toxins, Journal Year: 2021, Volume and Issue: 13(9), P. 648 - 648
Published: Sept. 13, 2021
The purpose of this study was to investigate the combined effects aflatoxin B1 and ochratoxin A on protein expression catalytic activities CYP1A2, CYP2E1, CYP3A29 GSTA1 preventive effect dietary byproduct antioxidants administration against these mycotoxin damage. Three experimental groups (E1, E2, E3) one control group (C) piglets after weaning (TOPIGS-40 hybrid) were fed with diets for 30 days. basal diet containing normal compound feed starter used as a treatment free mycotoxin. follows: E1—basal plus mixture (1:1) two byproducts (grapeseed sea buckthorn meal), E2—the experimentally contaminated mycotoxins (479 ppb OTA 62ppb AFB1) E3—basal 5% grapeseed meal mix AFB1. After 4 weeks, animals slaughtered, tissue samples taken from liver kidney in order perform microsomal fraction isolation, followed by enzymatic analyses. expressions CYP2E1 up-regulated an insignificant manner liver, whereas kidney, those down-regulated. decreased significant manner, increased significantly. co-presence grape seed generated tendency return values, which suggest that waste represent promising source counteracting harmful B.
Language: Английский
Citations
9
Sel skokhozyaistvennaya Biologiya, Journal Year: 2023, Volume and Issue: 57(6), P. 1147 - 1165
Published: Jan. 1, 2023
ПОНОМАРЕВА 1 , А.В.ДУБРОВИН Н.И.НОВИКОВА Д.А.АХМАТЧИН В.В.МОЛОТКОВ В.Х.МЕЛИКИДИ Е
Citations
3
Bioconjugate Chemistry, Journal Year: 2023, Volume and Issue: 34(10), P. 1727 - 1737
Published: Sept. 26, 2023
Glutathione S-transferase is heterogeneously expressed in breast cancer cells and therefore emerging as a potential diagnostic biomarker for studying the heterogeneity of cancers. However, available fluorescent probes GSTs depend heavily on GSTs-catalyzed glutathione (GSH) nucleophilic substitution reactions, making them susceptible to interference by high concentration species cellular environment. Moreover, functions subcellular are generally overlooked due lack suitable luminescence probes. Herein, we report highly selective affinity-based probe 1 GST through tethering inhibitor, ethacrynic acid, an iridium(III) complex. Compared activity-based which require use GSH, this could image GST-pi mitochondria directly adducting (or potentially GST-pi/GS) living cells. Probe possesses desirable photophysical properties including lifetime 911 ns, Stokes shift 343 nm, photostability. The "turn on" mode enables detection with limit 1.01 μM, while its long emission allows sensitive organic dye-spiked autofluorescence samples time-resolved mode. was further applied specifically quantitatively visualize MDA-MB-231 via specific binding mitochondrial GST, differentiate cell lines based their expression levels GST. To best our knowledge, first imaging Our work provides valuable tool unmasking diverse roles systems, well
Language: Английский
Citations
1
Toxicology Reports, Journal Year: 2024, Volume and Issue: 13, P. 101752 - 101752
Published: Sept. 27, 2024
Language: Английский
Citations
0
Metabolites, Journal Year: 2024, Volume and Issue: 14(11), P. 625 - 625
Published: Nov. 14, 2024
In broiler chickens, the efficient utilization of macro- and micronutrients is influenced by various metabolic pathways that are closely linked to feed efficiency (FE), a critical metric in poultry industry, with residual intake (RFI) as preferred proxy. Feed restriction considered an approach address underlying molecular mechanisms conversion. We hypothesized chickens divergent RFI subjected quantitative differ their pattern for nutrient liver post-absorptive tissue.
Language: Английский
Citations
0
Sel skokhozyaistvennaya Biologiya, Journal Year: 2023, Volume and Issue: 57(6), P. 1147 - 1165
Published: Jan. 1, 2023
ПОНОМАРЕВА 1 , А.В.ДУБРОВИН Н.И.НОВИКОВА Д.А.АХМАТЧИН В.В.МОЛОТКОВ В.Х.МЕЛИКИДИ Е
Citations
0
AIP conference proceedings, Journal Year: 2023, Volume and Issue: 2817, P. 020077 - 020077
Published: Jan. 1, 2023
Language: Английский
Citations
0