Early exposure to trans fat causes cognitive impairment by modulating the expression of proteins associated with oxidative stress and synaptic plasticity in Drosophila melanogaster
Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology,
Journal Year:
2024,
Volume and Issue:
279, P. 109858 - 109858
Published: Feb. 17, 2024
Language: Английский
Polyphenols as Suitable Control for Obesity and Diabetes
The Open Biotechnology Journal,
Journal Year:
2018,
Volume and Issue:
12(1), P. 219 - 228
Published: Sept. 28, 2018
Modern
life
is
characterized
by
physical
inactivity
and
poor
food
choices,
which
often
a
prerequisite
for
unhealthy
weight
gain
overweight/obesity.
These
factors
unlock
the
emergence
of
number
diseases
including
diabetes,
cardiovascular
problems,
different
types
cancer,
etc.
The
pursuit
scientists
to
seek
strategies
prevent,
relieve
cure
patient
leads
usage
natural
compounds
potential
beneficial
effect.
Polyphenols
are
large
group
naturally
occurring
secondary
metabolites
mainly
found
in
plants
beverages.
presence
these
seems
decrease
manifestation
miscellaneous
disease-causing
symptoms.
purpose
this
review
synthesize
information
about
polyphenols
their
controlling
obesity
diabetes.
considered
as
health-beneficial
sources
thus
could
be
involved
novel
preventing
diabetes
complications.
Language: Английский
Yohimbine Alleviates Oxidative Stress and Suppresses Aerobic Cysteine Metabolism Elevated in the Rat Liver of High-Fat Diet-Fed Rats
Molecules,
Journal Year:
2023,
Volume and Issue:
28(5), P. 2025 - 2025
Published: Feb. 21, 2023
Yohimbine
is
a
small
indole
alkaloid
derived
from
the
bark
of
yohimbe
tree
with
documented
biological
activity,
including
anti-inflammatory,
erectile
dysfunction
relieving,
and
fat-burning
properties.
Hydrogen
sulfide
(H2S)
sulfane
sulfur-containing
compounds
are
regarded
as
important
molecules
in
redox
regulation
involved
many
physiological
processes.
Recently,
their
role
pathophysiology
obesity
obesity-induced
liver
injury
was
also
reported.
The
aim
present
study
to
verify
whether
mechanism
activity
yohimbine
related
reactive
sulfur
species
formed
during
cysteine
catabolism.
We
tested
effect
at
doses
2
5
mg/kg/day
administered
for
30
days
on
aerobic
anaerobic
catabolism
oxidative
processes
high-fat
diet
(HFD)-induced
obese
rats.
Our
revealed
that
HFD
resulted
decrease
levels
liver,
while
sulfates
were
elevated.
In
rats,
rhodanese
expression
diminished
lipid
peroxidation
increased.
did
not
influence
thiol
however,
this
dose
mg
decreased
control
level
induced
rhodanese.
Moreover,
it
hepatic
peroxidation.
It
can
be
concluded
attenuates
enhances
induces
rat
liver.
mg/kg
alleviate
stress
reduce
elevated
concentrations
sulfate
probably
by
induction
TST
expression.
Language: Английский
Antioxidant Activity of Crocodile Oil (Crocodylus siamensis) on Cognitive Function in Rats
Foods,
Journal Year:
2023,
Volume and Issue:
12(4), P. 791 - 791
Published: Feb. 13, 2023
Crocodile
oil
(CO)
is
rich
in
monounsaturated
fatty
acids
and
polyunsaturated
acids.
The
antioxidant
activity
cognitive
effect
of
have
been
largely
reported.
This
work
aimed
to
investigate
the
CO
on
function
rats.
Twenty-one
rats
were
divided
into
three
treatment
groups:
(1)
sterile
water
(NS),
(2)
1
mL/kg
(NC1),
(3)
3
(NC3).
Rats
underwent
oral
gavage
once
daily
for
8
weeks.
decreased
triglycerides
level
significantly
compared
with
that
NS
group.
had
a
free
radical
scavenging
ability
greater
than
olive
but
no
levels
markers
brain.
Expression
unique
proteins
CO-treatment
group
correlated
detoxification
hydrogen
peroxide.
NC1
better
memory
NC3
was
function.
However,
did
not
cause
decline
can
be
an
alternative
dietary
because
it
has
hypolipidemia
activity.
In
addition,
negative
Language: Английский
Effect of the oil from the fatty tissues of Crocodylus siamensis on gut microbiome diversity and metabolism in mice
Kongphop Parunyakul,
No information about this author
Aphisara Chuchoiy,
No information about this author
Sasiporn Kooltueon
No information about this author
et al.
PLoS ONE,
Journal Year:
2023,
Volume and Issue:
18(7), P. e0289073 - e0289073
Published: July 28, 2023
Dietary
fat
can
alter
host
metabolism
and
gut
microbial
composition.
Crocodile
oil
(CO)
was
extracted
from
the
fatty
tissues
of
Crocodylus
siamensis.
CO,
rich
in
monounsaturated-
polyunsaturated
acids,
has
been
reported
to
reduce
inflammation,
counter
toxification,
improve
energy
metabolism.
The
aim
this
study
investigate
effect
CO
on
microbiota
(GM)
laboratory
mice
as
well
accompanying
metabolic
changes
animals.
Forty-five
C57BL/6
male
were
randomly
divided
into
five
groups
orally
administrated
either
sterile
water
(control
[C]);
1
or
3%
(v/w)
(CO-low
[CO-L]
CO-high
[CO-H],
respectively);
palm
(PO-low
PO-high,
respectively)
for
11
weeks.
Body
weight
gain,
food
intake,
blood
glucose
levels,
lipid
profiles
determined.
Samples
colon
tissue
collected
16S
rRNA
genes
pyrosequenced
clarify
GM
analyses.
results
showed
that
there
no
differences
body
levels.
Food
intake
by
CO-L
CO-H
statistically
significantly
less
when
compared
animals
C
group.
However,
neither
treatment
had
a
significant
calorie
controls.
exhibited
increase
serum
total
cholesterol
low-density
lipoprotein
but
downward
trend
triglyceride
levels
control.
analyses
revealed
both
treatments
have
influence
bacterial
diversity
relative
abundance
at
phylum
level,
whereas
increases
Choa1
abundance-based
coverage
estimator
indexes,
distinct
β-diversity,
Proteobacteria
observed
PO-high
group
with
Furthermore,
Azospirillum
thiophilum
Romboutsia
ilealis
higher
which
could
be
associated
activity.
Thus,
may
an
alternative
source
preserving
flora.
Language: Английский
Caiman’s fat enriched with n-3 fatty acids: potential food supplement
Tropical Animal Health and Production,
Journal Year:
2023,
Volume and Issue:
55(3)
Published: May 5, 2023
Language: Английский
Urtica Dioica Leaf Extract Attenuates Oxidative Stress Induced by Environment Pollutant Benzo[a] Pyrene in Mouse Testicular Tissues
The Open Biotechnology Journal,
Journal Year:
2023,
Volume and Issue:
17(1)
Published: Oct. 10, 2023
Background:
Epidemiological
studies
have
shown
that
elevated
levels
of
air
pollutants
are
associated
with
various
adverse
health
effects,
including
infertility.
Objective:
We
aimed
to
assess
the
protective
effects
aqueous
Urtica
dioica
leaf
extract
against
benzo[a]pyrene
-induced
oxidative
damage
in
mouse
testis.
Methods:
Mice
exposed
were
treated
or
without
for
five
weeks,
and
changes
body
testes
weights,
messenger
RNA
activities
antioxidant
enzymes,
plasma
testosterone
levels,
sperm
characteristics,
testicular
tissue
histology
determined.
Results:
Exposure
remarkably
reduced
testis
expression
activity
increased
lipid
peroxidation,
decreased
count
motility,
affected
morphology
viability,
damaged
seminiferous
tubules.
Treatment
attenuated
stress
by
increasing
genes.
Further,
antioxidative
enzyme
activity,
enhanced
improved
Conclusion:
Aqueous
protects
from
could
potentially
reverse
Language: Английский