Effects of Cadmium Pollution on Human Health: A Narrative Review

Atmosphere, Journal Year: 2025, Volume and Issue: 16(2), P. 225 - 225

Published: Feb. 17, 2025

Cadmium (Cd) is a pervasive environmental and industrial toxin that poses significant health risks. It readily moves through soil–plant systems, leading to global contamination human exposure diet, smoking, pollution. The main purpose of this review explore the effect Cd on physiological processes different bodies’ organs, including bones, kidneys, liver, as well immune, cerebrovascular, cardiovascular, reproductive systems. Accumulation in body can result poisoning with severe impacts bone kidney health, reduced mineral density due renal damage. Research has linked lung cancer pulmonary toxicity, elevated urinary biomarkers suggest compromised function. also affects immune systems; liver; contributing various diseases by disrupting blood pressure calcium regulation, causing oxidative stress DNA damage, impairing cell functions. Ongoing research essential fully understand Cd-induced toxicological effects develop effective interventions prevent mitigate

Language: Английский

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Dissecting the role of cadmium, lead, arsenic, and mercury in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 117134 - 117134

Published: Sept. 14, 2023

Language: Английский

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Baicalin and N-acetylcysteine regulate choline metabolism via TFAM to attenuate cadmium-induced liver fibrosis

Phytomedicine, Journal Year: 2024, Volume and Issue: 125, P. 155337 - 155337

Published: Jan. 7, 2024

Language: Английский

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SIRT5‐Mediated Desuccinylation of RAB7A Protects Against Cadmium‐Induced Alzheimer's Disease‐Like Pathology by Restoring Autophagic Flux

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 5, 2024

Cadmium (Cd) is a neurotoxic contaminant that induces cognitive decline similar to observed in Alzheimer's disease (AD). Autophagic flux dysfunction attributed the pathogenesis of AD, and this study aimed investigate effect autophagy on environmental Cd-induced AD progression underlying mechanism. Here, Cd exposure inhibited autophagosome-lysosome fusion impaired lysosomal function, leading defects autophagic clearance then APP accumulation nerve cell death. Proteomic analysis coupled with Ingenuity Pathway Analysis (IPA) identified SIRT5 as an essential molecular target Cd-impaired flux. Mechanistically, hampered expression SIRT5, thus increasing succinylation RAB7A at lysine 31 inhibiting activity, which contributed blockade. Importantly, overexpression led restoration blockade, alleviation Aβ deposition memory deficits, desuccinylation Cd-exposed FAD

Language: Английский

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Luteolin Alleviates Cadmium-Induced Kidney Injury by Inhibiting Oxidative DNA Damage and Repairing Autophagic Flux Blockade in Chickens

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 525 - 525

Published: April 26, 2024

Chickens are a major source of meat and eggs in human food have significant economic value. Cadmium (Cd) is common environmental pollutant that can contaminate feed drinking water, leading to kidney injury livestock poultry, primarily by inducing the generation free radicals. It necessary develop potential medicines prevent treat Cd-induced nephrotoxicity poultry. Luteolin (Lut) natural flavonoid compound mainly extracted from peanut shells has variety biological functions defend against oxidative damage. In this study, we aimed demonstrate whether Lut alleviate under Cd exposure elucidate underlying molecular mechanisms. Renal histopathology cell morphology were observed. The indicators renal function, stress, DNA damage repair, NAD+ content, SIRT1 activity, autophagy analyzed. vitro data showed increased ROS levels induced as indicated 8-OHdG γ-H2AX protein expression, over-activation repair enzyme PARP-1. decreased content activity LC3 II, ATG5, particularly p62 expression. addition, resulted PARP-1 over-activation, reduced autophagic flux blockade, evidenced reactive oxygen species scavenger NAC application. inhibition activation with pharmacological inhibitor PJ34 restored activity. activator RSV reversed blockade injury. vivo demonstrated treatment caused microstructural disruption tissues, creatinine, urea nitrogen clearance, raised MDA activities or contents antioxidants (GSH, T-SOD, CAT, T-AOC). activation, impaired flux. Notably, dietary supplement observably alleviated these alterations chicken tissues Cd. conclusion, through its potent antioxidant properties relieving damage-activated PARP-1-mediated reduction repairing blockade.

Language: Английский

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CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Cadmium (Cd) and polystyrene microplastics (PS-MPs), two ubiquitous environmental contaminants, produce unique synergistic toxicity when co-existing. Key unanswered questions include specific effects on liver function potential mechanisms. In this study, C57BL/6 mice AML12 cells were used to establish in vivo vitro models elucidate the of combined exposure PS-MPs Cd their The results showed that caused significantly more damage than alone. As observed by transmission electron microscopy (TEM), number autophagosomes was increased co-treated group. addition, autophagic flux assayed RFP-GFP-LC3, a reporter system expressing dual fluorescent proteins, which an overwhelming enhancement co-exposure compared To further investigate involvement carnitine palmitoyltransferase1(CPT1) injury induced PS-MPs, we co-exposed Baicalin, activator CPT1, with Cd, activation CPT1 alleviated impairment fluxes changes lipid accumulation associated protein levels. conclusion, concurrent resulted blockage hepatic pathway aggravated toxic liver. Activation could alleviate Cd-induced autophagy thus reducing injury.

Language: Английский

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Autophagy and the peroxisome proliferator-activated receptor signaling pathway: A molecular ballet in lipid metabolism and homeostasis

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

Poultry Science, Journal Year: 2024, Volume and Issue: 103(7), P. 103817 - 103817

Published: May 1, 2024

Cadmium (Cd) is a common environmental pollutant associated with an increased incidence of renal metabolic diseases. Luteolin (Lut), natural flavonoid, widely used for its multifaceted therapeutic properties in inflammatory However, whether Lut protects against Cd-induced nephrotoxicity still equivocal. The present study investigated the effects supplementation on oxidative stress, inflammation and metabolism their related mechanisms. Therefore, 40 chickens were treated Cd and/or automatic water free food intake 1 mo then kidney tissues collected to explore this issue. In study, exposure induced glycolipid disorders resultant damage by periodic acid Schiff (PAS) staining, Oil Red O total cholesterol (TC), triglyceride (TG), glucose (Glu) levels kidney, which significantly ameliorated Lut. Moreover, also normalized expression factors Cd-disturbed metabolism, improving homeostasis, contributing alleviating damage. Furthermore, demonstrated potential stress enhancing antioxidant capacity inhibiting cytokine production tissues. Mechanistically, activated AMPK/SIRT1/FOXO1 signaling pathway, attenuating responses, ameliorating disturbance. conclusion, these observations demonstrate that treatment activates decreases response, may contribute prevent disorder consequent

Language: Английский

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Cadmium promoted LPS-induced inflammation through TLR4/IκBα/NFκ-B signaling by increasing ROS-mediated incomplete autophagy

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 278, P. 116405 - 116405

Published: May 1, 2024

Cadmium (Cd) exposure is considered as non-infectious stressor to human and animal health. Recent studies suggest that the immunotoxicity of low dose Cd not directly apparent, but disrupts immune responses when infected with some bacteria or virus. But how alters adaptive immunity organ cells remains unclear. In this study, we applied lipopolysaccharide (LPS, infectious stressor) induced inflammation in spleen tissues T cells, investigated effects after underlying mechanism. promoted LPS-induced expressions inflammatory factors, abnormal initiation autophagy, blocked autophagic flux. The under LPS activation were reversed by autophagy promoter Rapamycin. Under conditions, also oxidative stress increasing levels reactive oxygen species (ROS) malondialdehyde (MDA), reducing total antioxidant capacity (T-AOC) activity. increased superoxide dismutase (SOD) activity might be a negative feedback passive regulation stress. Cd-increased flux inhibition TNF-α expression ROS scavenger α-tocopherol (TCP). Furthermore, condition, toll-like receptor 4 (TLR4)/IκBα/NFκ-B signaling pathway TLR4 protein stability, which abolished pretreatment present study confirmed that, ROS-mediated inhibiting degradation TLR4, cells. This identified mechanism Cd-aggravated stress, could arouse public attention synergistic toxicity bacterial virus infection.

Language: Английский

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A new insight of cadmium-induced cellular evidence of autophagic-associated spermiophagy during spermatogenesis

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(45), P. 101064 - 101074

Published: Aug. 30, 2023

Language: Английский

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