Cooperative application of transcriptomics and ceRNA hypothesis: lncRNA-00742/miR-116 targets CD74 to mediate vanadium-induced mitochondrial apoptosis in duck liver

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135904 - 135904

Published: Sept. 19, 2024

Language: Английский

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AQP1 Deficiency Drives Phthalate-Induced Epithelial Barrier Disruption through Intestinal Inflammation

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(27), P. 15334 - 15344

Published: June 25, 2024

Di-2-ethylhexyl phthalate (DEHP) is frequently used as a plasticizer to enhance the plasticity and durability of agricultural products, which pose adverse effects human health environment. Aquaporin 1 (AQP1) main water transport channel protein involved in maintenance intestinal integrity. However, impact DEHP exposure on gut its potential mechanisms remain elusive. Here, we determined that induced compromised duodenum structure, was concomitant with mitochondrial structural injury epithelial cells. Importantly, caused inflammatory cell damage strong response accompanied by activating TLR4/MyD88/NF-κB signaling pathway. Mechanistically, directly inhibits expression AQP1 thus leads an response, ultimately disrupting integrity barrier function. Collectively, our findings uncover role phthalate-induced disorders, could be promising therapeutic approach for treating patients disorders or diseases.

Language: Английский

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The mitochondria-targeted antioxidant MitoQ ameliorates inorganic arsenic-induced DCs/Th1/Th2/Th17/Treg differentiation partially by activating PINK1-mediated mitophagy in murine liver

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 277, P. 116350 - 116350

Published: April 22, 2024

Inorganic arsenic is a well-established environmental toxicant linked to acute liver injury, fibrosis, and cancer. While oxidative stress, pyroptosis, ferroptosis are known contributors, the role of PTEN-induced kinase 1 (PINK1)-mediated mitophagy in arsenic-induced hepatic immunotoxicity remains underexplored. Our study revealed that exposure prompts differentiation dendritic cells (DCs) T helper (Th) 1, Th2, Th17, regulatory (Treg) cells, alongside increased transcription factors cytokines. triggered redox imbalance, leading elevated alanine transaminase (ALT), hydrogen peroxide (H

Language: Английский

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Copper as the driver of the lncRNA-TCONS-6251/miR-novel-100/TC2N axis: Unraveling ferroptosis in duck kidney

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136797 - 136797

Published: Oct. 23, 2024

Language: Английский

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The possible association of mitochondrial fusion and fission in copper deficiency-induced oxidative damage and mitochondrial dysfunction of the heart

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 85, P. 127483 - 127483

Published: June 13, 2024

Language: Английский

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Pesticide butachlor exposure perturbs gut microbial homeostasis

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116646 - 116646

Published: July 1, 2024

Agricultural production relies heavily on the use of pesticides, which may accumulate in soil and water, posing a significant threat to global ecological environment biological health. Butachlor is commonly used herbicide environmental pollutant, has been linked liver kidney damage, as well neurological abnormalities. However, potential impact butachlor exposure gut microbiota remains understudied. Thus, our aim was investigate negative effects host health microbiota. Our results demonstrated that significantly reduced antioxidant capacity, evidenced by decreased levels T-AOC, SOD, GSH-Px, increased MDA. Serum biochemical analysis also revealed increase AST ALT during exposure. Microbial showed abundance diversity Furthermore, altered microbial composition. In conclusion, findings indicate can have detrimental effects, including dysregulation enzymes, abnormalities transaminases, hepatointestinal damage. it disrupts homeostasis altering composition reducing abundance. context increasingly serious this study will help provide impetus for standardizing application pesticides pollution.

Language: Английский

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Thiram exposure: Disruption of the blood-testis barrier and altered apoptosis-autophagy dynamics in testicular cells via the Bcl-2/Bax and mTOR/Atg5/p62 pathways in mice

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 203, P. 106010 - 106010

Published: July 3, 2024

Language: Английский

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Hesperidin alleviates kidney injury induced by nano-copper through regulating endoplasmic reticulum stress and autophagy via AMPK-AKT/mTOR pathway in broiler chicken

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105980 - 105980

Published: Jan. 1, 2025

Language: Английский

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Decoding ozone's impact on the cornea: disruption of barrier integrity and its molecular drivers

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 296, P. 118213 - 118213

Published: April 22, 2025

Language: Английский

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Huang Lian Jie Du decoction attenuates inflammation in septic rats by activating autophagy and altering the intestinal microbiome

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e31607 - e31607

Published: May 23, 2024

AimsThe aim of this study was to investigate the protective effect HLJDD on septic rats and underlying mechanisms.Materials methodsAdult male Sprague–Dawley (SD) adult (150–180 g) were randomly divided into following 5 groups (n = 7 per group): Sham group, caecal ligation puncture (CLP) + CLP (Huang Lian Jie Du Decoction, HLJDD) group (1 g/mL/100 g), Rap (H. Rap) (Rap: 3 mg/kg), HLJDD+3-MA 3-MA) (3-MA: 30 mg/kg). Rapamycin (Rap) 3-methyladenosine (3-MA) used activate inhibit autophagy, respectively. purchased from Beijing Tong Ren Tang Guiyang Branch verified by experts as a genuine product. We establish an animal model sepsis in last four groups. Survival analysed Kaplan‒Meier method. Then, we examined autophagy-related genes (Atgs) proteins using real-time PCR Western blotting, The microstructure ileum number autophagosomes observed transmission electron microscopy (TEM). Analyses HE-stained pathological inflammatory factor levels assess extent injury. gut microbiota 16S rRNA gene sequencing faeces.ResultsIn study, identified effects mortality inflammation rats. Several key proteins, including LC3-II, Beclin-1 p62, showed that could effectively reverse sepsis-induced decrease autophagy. TEM performed expression Atgs assessed evaluate fluctuations intestinal tight junction protein zona occludens (ZO-1), lipopolysaccharide (LPS) factors, found alleviated increase ZO-1 expression, level LPS serum factors caused sepsis. These results consistent with those obtained sectioning analysis. Moreover, autophagy activation ameliorated sepsis, inhibition exacerbated systemic symptoms infection. By examining upstream pathway, inhibited mTOR via MAPK/PI3K signalling pathway promote revealed significantly affected diversity physiological function rats.ConclusionsThe indicate is potential mechanism intestine

Language: Английский

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