Triptolide exposure triggers testicular vacuolization injury by disrupting the Sertoli cell junction and cytoskeletal organization via the AKT/mTOR signaling pathway

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116502 - 116502

Published: May 24, 2024

Despite the known reproductive toxicity induced by triptolide (TP) exposure, regulatory mechanism underlying testicular vacuolization injury caused TP remains largely obscure.

Language: Английский

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Development of fatty liver disease model using high cholesterol and low choline diet in white leghorn chickens

Veterinary Research Communications, Journal Year: 2024, Volume and Issue: 48(4), P. 2489 - 2497

Published: June 11, 2024

Abstract Nonalcoholic fatty liver disease (NAFLD), which shows similar symptoms as hemorrhage syndrome (FLHS) in chickens, is the most common cause of chronic and cancer humans. NAFLD patients FLHS chickens have demonstrated severe disorders when infected by emerging strains human hepatitis E virus (HEV) avian HEV, respectively. We sought to develop a chicken model altering diet 3-week-old white leghorn chickens. The high cholesterol, low choline (HCLC) included 7.6% fat with additional 2% cholesterol 800 mg/kg comparison 5.3% fat, 1,300 regular diet. Our induced successfully recapitulates clinical features seen during humans including hyperlipidemia hepatic steatosis, indicated significantly higher serum triglycerides, acids. By developing this model, we expect provide platform explore role lipids pathology linked viral infections contribute development prophylactic interventions.

Language: Английский

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Exogenous autoinducer-2 alleviates intestinal damage in necrotizing enterocolitis via PAR2/MMP3 signaling pathway

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 138, P. 112567 - 112567

Published: June 30, 2024

Language: Английский

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Arsenic induces hepatotoxicity in chickens via PANoptosis pathway

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 204, P. 106064 - 106064

Published: July 30, 2024

Language: Английский

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13-Methylpalmatine improves myocardial infarction injury by inhibiting CHOP-mediated cross-talk between endoplasmic reticulum and mitochondria

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117342 - 117342

Published: Aug. 24, 2024

Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide, endoplasmic reticulum stress (ERS) mitochondrial Ca

Language: Английский

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Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117085 - 117085

Published: Sept. 24, 2024

Language: Английский

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COPPER DYSHOMEOSTASIS AND ITS RELATIONSHIP TO AMPK ACTIVATION, MITOCHONDRIAL DYNAMICS, AND BIOGENESIS OF MITOCHONDRIA: A SYSTEMATIC REVIEW OF IN VIVO STUDIES

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127549 - 127549

Published: Oct. 11, 2024

Language: Английский

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Ambient fine particulate matter provokes multiple modalities of cell death via perturbation of subcellular structures

Environment International, Journal Year: 2024, Volume and Issue: 195, P. 109193 - 109193

Published: Dec. 13, 2024

Fine particulate matter (PM2.5) is increasingly recognized for its detrimental effects on human health, with substantial evidence linking exposure to various forms of cell death and dysfunction across multiple organ systems. This review examines key mechanisms triggered by PM2.5, including PANoptosis, necroptosis, autophagy, ferroptosis, while other such as oncosis, paraptosis, cuprotosis remain unreported in relation PM2.5 exposure. Mitochondria, endoplasmic reticulum, lysosomes emerge pivotal organelles the disruption cellular homeostasis, mitochondrial particularly implicated metabolic dysregulation activation pro-apoptotic pathways. Although primarily affects nucleus, cytoskeleton, mitochondria, lysosomes, like ribosomes, Golgi apparatus, peroxisomes have received limited attention. Interactions between these organelles, reticulum-associated membranes, lysosome-associated mitophagy, mitochondria-nuclei retro-signaling may significantly contribute cytotoxic PM2.5. The toxicity, encompassing oxidative stress, inflammatory responses, imbalances, are described detail. Notably, activates NLRP3 inflammasome, amplifying responses contributing chronic diseases. Furthermore, disrupts genetic epigenetic regulation, often resulting cycle arrest exacerbating damage. composition, concentration, seasonal variability modulate effects, underscoring complexity PM2.5-induced dysfunction. Despite significant advances understanding pathways, further research required elucidate long-term exposure, role potential strategies mitigate harmful impact health.

Language: Английский

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Hesperidin alleviates terbuthylazine-induced ferroptosis via maintenance of mitochondria-associated endoplasmic reticulum membrane integrity in chicken hepatocytes

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2024, Volume and Issue: 284, P. 109989 - 109989

Published: July 30, 2024

Language: Английский

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Phillyrin promotes autophagosome formation in A53T-αSyn-induced Parkinson's disease model via modulation of REEP1

Phytomedicine, Journal Year: 2024, Volume and Issue: 134, P. 155952 - 155952

Published: Aug. 18, 2024

Language: Английский

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