Effects of isoquinoline alkaloids as an alternative to antibiotic on oxidative stress, inflammatory status, and cecal microbiome of broilers under high stocking density DOI Creative Commons

Kittisak Insawake,

Thaweesak Songserm,

Ornprapun Songserm

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104671 - 104671

Published: Dec. 13, 2024

This study investigated the effect of isoquinoline alkaloids as an alternative to bacitracin on growth performance, oxidative stress, inflammatory status, and ceca microbiome broilers raised under high stocking density (HSD). A total 1,500 one-day-old male Ross 308 chicks were randomly assigned five treatment groups, with 10 replicate pens per group 30 birds pen, for 37 days. The treatments included normal (NSD, birds/m²), HSD (15 50 ppm Bacitracin (BCT50), 80 (IQA80), 100 (IQA100). From days 11 24, had lower feed efficiency (P < 0.05) compared those in other treatments. heterophil-to-lymphocyte ratio malondialdehyde levels NSD IQA80 BCT50 0.05). higher IL-6 a villus height height-to-crypt depth groups Serum TNF-α was group. Alpha diversity not affected by treatments; however, beta showed reduced microbial diversity, prevalence Enterococcaceae Peptostreptococcaceae. enhanced abundance Lactobacillaceae, Clostridiaceae, Rikenellaceae. increased decreased Rikenellaceae respectively. IQA100 Lachnospiraceae, Leuconostocaceae, Coriobacteriaceae. altered metabolic pathways related carbohydrate lipid metabolism, amino acid biosynthesis. modulated functions, particularly cell wall synthesis, while upregulated involved energy production, secondary metabolite biosynthesis, antioxidant production. Both effective mitigating negative effects immunity, gut health microbiota broilers. Given concerns about antimicrobial resistance, are potent bacitracin, being recommended.

Language: Английский

Nutrigenomic evidence of phytogenic cytoprotective functions in the ovary and liver provides mechanistic support for improved laying hen performance DOI Creative Commons
Ioannis P. Brouklogiannis, Konstantinos C. Mountzouris

Animal Biotechnology, Journal Year: 2025, Volume and Issue: 36(1)

Published: Feb. 13, 2025

The study assessed the inclusion level effects of a phytogenic blend (PB) on performance and critical molecular biomarkers related to detoxification (Aryl hydrocarbon receptor; AhR) antioxidant (Nuclear factor-erythroid 2-related factor 2; Nrf2) responses in layers' ovary liver. Layers (n = 385; 21-week-old; Hy-Line Brown) were allotted 5 treatments with 7 replicates 11 hens each, for 12-week feeding trial. Treatments were: control (CON) without PB or supplementation at 250 (PB250), 750 (PB750), 1000 (PB1000) 1500 mg/kg diet (PB1500), respectively. Performance was determined weekly experimental period. At 6th 12th week ovarian liver samples collected gene expression analysis. Increasing level, improved linearly quadratically overall laying rate, egg mass FCR, optimal (P ≤ 0.001) notable PB750 compared CON. nutrigenomic analysis revealed that resulted 0.05) consistent beneficial modulation AhR/Nrf2 pathway-related genes week, both hens. In conclusion, beneficially modulated hepatic adaptive cytoprotection supported improvements recorded, displaying benefits.

Language: Английский

Citations

0
Influence of phytochemicals on growth performance, gut morphology and ceca microbiome in broilers fed aflatoxin-contaminated diet and raised under high stocking density and heat stress DOI Creative Commons

Kittisak Insawake,

Thaweesak Songserm,

Ornprapun Songserm

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105293 - 105293

Published: May 1, 2025

Language: Английский

Citations

0
Oxidative Stress in Poultry and the Therapeutic Role of Herbal Medicine in Intestinal Health DOI Creative Commons
Yuan Li, Kai Wang, Chunmei Li

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1375 - 1375

Published: Nov. 10, 2024

The intensive broiler farming model has accelerated the development of poultry industry. However, it also inevitably brought about many stressors that lead to oxidative stress in organism. intestine is leading site nutrient digestion, absorption, and metabolism, as well a secretory immune organ. Oxidative animal production can harm intestine, potentially significant losses for Under conditions stress, free radicals are produced animal's body, attacking intestinal mucosal tissues destroying barrier integrity tract, disease. Recently, herbs have been shown favorable safety profile promising application improving poultry. Therefore, future in-depth studies on specific mechanisms their extracts treating provide theoretical basis clinical new therapeutic options injury during farming. This review focuses causes hazards tract poultry, with potential, reference developing applying antioxidants.

Language: Английский

Citations

3
Effects of isoquinoline alkaloids as an alternative to antibiotic on oxidative stress, inflammatory status, and cecal microbiome of broilers under high stocking density DOI Creative Commons

Kittisak Insawake,

Thaweesak Songserm,

Ornprapun Songserm

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104671 - 104671

Published: Dec. 13, 2024

This study investigated the effect of isoquinoline alkaloids as an alternative to bacitracin on growth performance, oxidative stress, inflammatory status, and ceca microbiome broilers raised under high stocking density (HSD). A total 1,500 one-day-old male Ross 308 chicks were randomly assigned five treatment groups, with 10 replicate pens per group 30 birds pen, for 37 days. The treatments included normal (NSD, birds/m²), HSD (15 50 ppm Bacitracin (BCT50), 80 (IQA80), 100 (IQA100). From days 11 24, had lower feed efficiency (P < 0.05) compared those in other treatments. heterophil-to-lymphocyte ratio malondialdehyde levels NSD IQA80 BCT50 0.05). higher IL-6 a villus height height-to-crypt depth groups Serum TNF-α was group. Alpha diversity not affected by treatments; however, beta showed reduced microbial diversity, prevalence Enterococcaceae Peptostreptococcaceae. enhanced abundance Lactobacillaceae, Clostridiaceae, Rikenellaceae. increased decreased Rikenellaceae respectively. IQA100 Lachnospiraceae, Leuconostocaceae, Coriobacteriaceae. altered metabolic pathways related carbohydrate lipid metabolism, amino acid biosynthesis. modulated functions, particularly cell wall synthesis, while upregulated involved energy production, secondary metabolite biosynthesis, antioxidant production. Both effective mitigating negative effects immunity, gut health microbiota broilers. Given concerns about antimicrobial resistance, are potent bacitracin, being recommended.

Language: Английский

Citations

3