Prenatal medication exposure and epigenetic outcomes: a systematic literature review and recommendations for prenatal pharmacoepigenetic studies

Epigenetics, Journal Year: 2021, Volume and Issue: 17(4), P. 357 - 380

Published: April 29, 2021

When used during pregnancy, analgesics and psychotropics pass the placenta to enter foetal circulation may induce epigenetic modifications. Where such modifications occur whether they disrupt normal developme nt, are currently unanswered questions. This field of prenatal pharmacoepigenetics has received increasing attention, with several studies reporting associations between in utero medication exposure offspring outcomes. Nevertheless, no recent systematic review literature is available. Therefore, objectives this were (i) provide an overview on association a nd outcomes, (ii) suggest recommendations for future within pharmacoepigenetics. We performed searches five databases. The eligible assessed human or analgesics, analyses tissue as outcome. identified 18 including 4,419 neonates exposed either antidepressants, antiepileptic drugs, paracetamol, acetylsalicylic acid, methadone. outcome all was DNA methylation cord blood, placental buccal cells. Although most found significant differences upon exposure, almost persistent across similar medications sequencing methods. reviewed challenging compare due poor transparency reporting, heterogeneous methodology, design, genome coverage, statistical modelling. propose 10 pharmacoepigenetic considering both epidemiological perspectives. These improve quality, comparability, clinical relevance studies. PROSPERO registration ID: CRD42020166675.

Language: Английский

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DNA methylation alterations and their potential influence on macrophage in periodontitis

Oral Diseases, Journal Year: 2020, Volume and Issue: 28(2), P. 249 - 263

Published: Sept. 29, 2020

To explore how various methylation mechanisms function and affect macrophages in periodontitis, with an aim of getting a comprehensive understanding pathogenesis the disease. Alterations DNA are associated different periodontitis susceptible factors disrupt immunity homeostasis. The host's immune response to stimulus plays vital role progression periodontitis. Macrophages key cells system. They act as critical regulators maintaining issue homeostasis their nature high plasticity. altered status genes may cause abnormal expression proteins progress thus, exert potential influence on macrophages. Certain selectively activated or silenced due changes status, which causes alteration level cytokines/chemokines, signal molecules, extracellular matrix leads change local microenvironment, affects activation states including macrophages, thus influences host during periodontitis.. This results differential susceptibility therapeutic outcome. aberrant periodontal diseases, deregulation supports prospect using methylation-related parameter new biomarker for diagnosis treatment

Language: Английский

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Early developmental stage glucocorticoid exposure causes DNA methylation and behavioral defects in adult zebrafish

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2022, Volume and Issue: 256, P. 109301 - 109301

Published: Feb. 17, 2022

Language: Английский

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The impact of parental and developmental stress on DNA methylation in the avian hypothalamic–pituitary–adrenal axis

Molecular Ecology, Journal Year: 2024, Volume and Issue: 33(6)

Published: Feb. 11, 2024

Abstract The hypothalamic–pituitary–adrenal (HPA) axis coordinates an organism's response to environmental stress. responsiveness and sensitivity of offspring's stress may be shaped not only by stressors encountered in their early post‐natal environment but also parent's environment. Yet, few studies have considered how both these life environments function together impact the developing HPA axis. Here, we manipulated parental a population house sparrows ( Passer domesticus ) assess on changes DNA methylation (and corresponding gene expression) suite genes within We found that nestlings experienced across life‐history periods had higher critical gene, glucocorticoid receptor NR3C1 ). In addition, stage when was impacted some HSD11B1, NR3C2 differently. evidence for mitigation (in HSD11B1 Finally, assessing brain blood, were able evaluate cross‐tissue patterns. While differentially methylated regions tissue‐specific, , suggesting blood is suitable tissue as biomarker Our results provide crucial first step understanding mechanisms which different contributes epigenome

Language: Английский

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Effects of social environments on male primate HPG and HPA axis developmental programming

Developmental Psychobiology, Journal Year: 2024, Volume and Issue: 66(5)

Published: May 2, 2024

Developmental plasticity is particularly important for humans and other primates because of our extended period growth maturation, during which phenotypes adaptively respond to environmental cues. The hypothalamus-pituitary-gonadal (HPG) hypothalamus-pituitary-adrenal (HPA) axes are likely be principal targets developmental "programming" given their roles in coordinating fitness-relevant aspects the phenotype, including sexual development, adult reproductive social strategies, internal responses external environment. In animals, humans, environment believed an source cues these may respond. effects early environments on HPA axis have been widely studied some extent, primates, but there still major gaps knowledge specifically relating males. There has also relatively little research examining role that play programming HPG or HPA/HPG interface, what does exist disproportionately focuses females. These topics understudied males part due difficulty identifying milestones relative females general quiescence prior maturation. However, clear indicators life matter both sexes. this review, we examine known about impact male development nonhuman epigenetic mechanisms programming. We conclude by highlighting next steps area.

Language: Английский

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