Association between endocrine-disrupting chemical mixtures and non-alcoholic fatty liver disease with metabolic syndrome as a mediator among adults: A population-based study in Korea

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 276, P. 116310 - 116310

Published: April 12, 2024

Endocrine-disrupting chemicals (EDCs) may play a role in non-alcoholic fatty liver disease (NAFLD); however, studies on the combined effects of EDC mixtures NAFLD development are limited. Here, we explored association between exposure to and investigated potential mediating metabolic syndrome (MetS). We included participants from Korean National Environmental Health Survey Cycle 4 (2018-2020) quantified urinary concentrations various EDCs-eight phthalate metabolites, three phenols, one antibacterial compound, four parabens, polycyclic aromatic hydrocarbons, pyrethroid pesticide metabolite-as well as serum five perfluorinated compounds (PFCs). was defined hepatic steatosis index (HSI) ≥36 or (FLI) ≥60. Weighted quantile sum (WQS) regression employed evaluate associations risk MetS NAFLD. Causal mediation analysis conducted explore effect EDCs risk. All estimates were adjusted for age, sex, educational level, physical activity, smoking status, involuntary smoking, drinking habits. A total 2942 adults analysis. Moderate-to-high positive correlations identified metabolites PFCs. Higher WQS scores associated with an elevated The sex-stratified model showed that interactions sex significant According causal analysis, both direct indirect NAFLD, mediator, females. Collectively, these findings highlight need interventions could address mixture status effectively reduce risks its related complications.

Language: Английский

Physical activity patterns and cognitive function in elderly women: a cross-sectional study from NHANES 2011–2014

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: June 12, 2024

Amid the backdrop of global aging, increasing prevalence cognitive decline among elderly, particularly within female demographic, represents a considerable public health concern. Physical activity (PA) is recognized as an effective non-pharmacological intervention for mitigating in older adults. However, relationship between different PA patterns and function (CF) elderly women remains unclear.

Language: Английский