Comparison of Synapse 3D system (Version 4.4) and DirectPath system (Version 2.0) in virtual bronchoscopic navigation application for peripheral pulmonary nodules DOI Creative Commons
Xiang Li, Sen Tian, Yifei Zhang

et al.

Therapeutic Advances in Respiratory Disease, Journal Year: 2024, Volume and Issue: 18

Published: Jan. 1, 2024

Background: Differences between virtual bronchoscopic navigation (VBN) systems and their impacts on the diagnostic yield of transbronchial biopsy (TBB) peripheral pulmonary nodules (PPNs) remain unclear. Objectives: To compare Synapse 3D system (Version 4.4, Fujifilm, Japan) DirectPath 2.0, Olympus, in VBN application PPNs. Design: Retrospective study with self-paired design exploratory retrospective cohort design. Methods: The analyzed patients PPNs using (Group S) D) compared differences two groups bronchial tree reconstruction, pathway planning, VBN-assisted TBB Results: In all, 289 were ultimately. Bronchial reconstruction quality was better Group S ( p < 0.001). Navigation planning duration longer than that D (median 1.35 vs 1.04 s, Automated success rate higher (36.7% 19.7%, 0.001), CT image parameter nodule diameter, bronchus sign, distance from hilum had significant effects it both groups. Fifty-six forty-two localization not significantly different (85.3% 91.2% 67.6% 61.8%, respectively, > 0.05). Conclusion: 4.4) 2.0) own merits. Localization no statistical difference for these systems. Improvements segmentation algorithms most suitable chest scan data them may be breakthrough to improve efficiency VBN, especially poor experienced interventional physicians.

Language: Английский

EBUS-guided cryobiopsy in the diagnosis of thoracic disorders DOI Creative Commons
Venerino Poletti, Simone Petrarulo, Sara Piciucchi

et al.

Pulmonology, Journal Year: 2024, Volume and Issue: 30(5), P. 459 - 465

Published: Jan. 5, 2024

Endobronchial Ultrasound (EBUS) has emerged as a crucial tool for diagnosing intrathoracic disorders, particularly in the staging of lung cancer. However, its diagnostic capabilities context benign and rare diseases remain subject debate. to investigate yield safety EBUS-transbronchial mediastinal cryobiopsy (EBUS-TMC) comparison needle aspiration (TBNA) broad spectrum diseases. single-centre retrospective observational study conducted on 48 patients who underwent both EBUS-TBNA endobronchial ultrasound-transbronchial same procedure between August 2021 October 2023. The overall EBUS-TMC surpassed that (95.8% vs 54.1 %), notably excelling diagnosis sarcoidosis (92.8% 78.5 disorders (100% 0 hyperplastic lymphadenopathy lymphoproliferative disease %). No significant differences were observed NSCLC SCLC. Samples obtained through facilitated acquisition NGS immunohistochemical analyses more readily. may contribute precise subtyping diseases, especially lymphomas tumors, thereby reducing number non-diagnostic procedures.

Language: Английский

Citations

16
Comparison of cryobiopsy and forceps biopsy for the diagnosis of mediastinal lesions: A randomised clinical trial DOI Creative Commons
Tian‐Lu Cheng, Zhi‐Shu Huang, Jing Zhang

et al.

Pulmonology, Journal Year: 2024, Volume and Issue: 30(5), P. 466 - 474

Published: Jan. 5, 2024

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the standard approach for lung cancer staging. However, its diagnostic utility other mediastinal diseases might be hampered by limited tissue retrieved. Recent evidence suggests novel sampling strategies of forceps biopsy and cryobiopsy as auxiliary techniques to EBUS-TBNA, considering their capacity larger samples. This study determined added value diagnosis diseases. Consecutive patients with lesions 1 cm or more in short axis were enrolled. Following completion aspiration, three biopsies one performed a randomised pattern. Primary endpoints included yield defined percentage whom led definite diagnosis, procedure-related complications. In total, 155 recruited randomly assigned. Supplementing EBUS-TBNA either increased yield, no significant difference between plus (85.7 % versus 91.6 %, P = 0.106). Yet, samples obtained additional cryobiopsies qualified molecular testing than those from (100.0 89.5 0.036). When compared directly, overall was superior 70.8 0.001). Cryobiopsies produced greater shorter procedural time biopsies. Two (1.3 %) cases postprocedural pneumothorax detected. Transbronchial promising complementary tool supplement traditional harvesting. ChiCTR2000030373

Language: Английский

Citations

16
Radial endobronchial ultrasound - guided bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta-analysis of prospective trials DOI Creative Commons

Sen Tian,

Xiang Li,

Jian Liu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e29446 - e29446

Published: April 1, 2024

The diagnostic yield of radial endobronchial ultrasound (r-EBUS) for the diagnosis peripheral pulmonary lesions (PPLs) varies between studies and is affected by multiple factors. We aimed to evaluate efficacy safety r-EBUS, explore factors influencing r-EBUS in patients with PPLs.

Language: Английский

Citations

3
ETV6-NTRK2 Fusion in a Patient With Metastatic Pulmonary Atypical Carcinoid Successfully Treated With Entrectinib: A Case Report and Review of the Literature DOI
Wusheng Zhang, Sen Tian, X. Li

et al.

Clinical Lung Cancer, Journal Year: 2024, Volume and Issue: 25(3), P. 215 - 224.e3

Published: March 19, 2024

Language: Английский

Citations

2
The Diagnostic Efficiency and Safety of Transbronchial Lung Cryobiopsy Using 1.1-mm Cryoprobe in Diagnosing Interstitial Lung Disease DOI

Yiding Bian,

Mingming Deng, Qian Gao

et al.

Lung, Journal Year: 2024, Volume and Issue: 202(5), P. 615 - 623

Published: June 23, 2024

Language: Английский

Citations

2
An explorative analysis on the optimal cryo-passes and freezing time of the ultrathin cryoprobe in endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy DOI Creative Commons
Sze Shyang Kho, Shirin Hui Tan, Chun Ian Soo

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 12, 2024

Abstract EBUS-guided transbronchial mediastinal cryobiopsy (TBMC) has emerged as a promising biopsy tool for diagnosing hilar and pathologies. However, several fundamental technical aspects of TBMC remain unexplored. This study aims to determine the optimal number cryo-passes freezing time ultrathin cryoprobe in EBUS-TBMC concerning specimen size procedural diagnostic yield. We conducted retrospective chart review patients with lesions who underwent between January 2021 April 2023 across three hospitals Malaysia. A total 129 procedures were successfully completed, achieving an overall yield 88.4%. Conclusive associated larger sizes (7.0 vs. 5.0 mm, p < 0.01). Specimen demonstrated positive correlation ( 0.01), plateauing at 4.1–6.0 mm. significant was also observed both 0.01) 0.05). Diagnostic plateaued after 2–3 cryo-passes. In contrast, longer times trended towards smaller specimens lower yield, though not reaching statistical significance. The highest recorded 3.1–4.0 s time. safety profile remains favourable, one case (0.8%) pneumothorax nine cases (7%) self-limiting bleeding. our cohort, performance achieve aggregate mm appeared optimal. Further prospective studies are needed validate these findings.

Language: Английский

Citations

2
Bronchoscopy with and without needle-based confocal laser endomicroscopy for peripheral lung nodule diagnosis: protocol for a multicentre randomised controlled trial (CLEVER trial) DOI Creative Commons
Saskia van Heumen, Tess Kramer, Daniël A. Korevaar

et al.

BMJ Open, Journal Year: 2024, Volume and Issue: 14(7), P. e081148 - e081148

Published: July 1, 2024

Introduction Despite many technological advances, the diagnostic yield of bronchoscopic peripheral lung nodule analysis remains limited due to frequent mispositioning. Needle-based confocal laser endomicroscopy (nCLE) enables real-time microscopic feedback on needle positioning, potentially improving sampling location and yield. Previous studies have defined validated nCLE criteria for malignancy, airway parenchyma. Larger demonstrating effect are lacking. We aim investigate if nCLE-imaging integrated with conventional bronchoscopy results in a higher compared without nCLE. Methods This is parallel-group randomised controlled trial. Recruitment performed at pulmonology outpatient clinics universities general hospitals six different European countries one hospital USA. Consecutive patients malignancy suspected (10–30 mm) an indication will be screened, 208 included. Web-based randomisation (1:1) between two procedures performed. The primary outcome Secondary outcomes include sensitivity repositionings, procedure fluoroscopy duration, complications. Pathologists blinded type; endoscopists not. Ethics dissemination Primary approval by Committee Amsterdam University Medical Center. Dissemination involves publication peer-reviewed journal. Support Financial material support from Mauna Kea Technologies. Trial registration number NCT06079970 .

Language: Английский

Citations

1
The diagnostic efficiency and safety of transbronchial lung cryobiopsy using 1.1-mm cryoprobe in diagnosing interstitial lung disease DOI Creative Commons

Yiding Bian,

Mingming Deng, Qian Gao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 29, 2024

Abstract Introduction: Transbronchial lung cryobiopsy (TBLC) is increasingly used to diagnose interstitial disease (ILD). The 1.1-mm cryoprobe has recently been available in clinical practice. diagnostic yield and safety of TBLC using a need be confirmed. Methods: A prospective, randomized controlled trial was conducted patients with suspected ILD randomly assigned 1.9-mm groups. primary outcome the multidisciplinary discussion (MDD). Secondary outcomes were sample quality incidence complications. tension stress effects during onto target lobe caused by 1.1-mm, 1.9-mm, 2.4 mm cryoprobes also evaluated finite element analysis. Results: total 224 enrolled. No significant differences observed (80.4% vs. 79.5%, p =0.845) scores (5.73±0.64 5.66±0.77; =0.324) between group group. average surface areas samples smaller, while no difference weights observed. decreased moderate bleeding found (17.0% 6.2%, =0.027), pneumothorax higher but did not reach statistical significance (1.8% 7.1%, =0.070). In analysis, required largest produced stress. Conclusion: Compared cryoprobe, there specimen or rate smaller size cryoprobe. Trail registration: clinicaltrials.gov identifier NCT04047667; registered August 4, 2019

Language: Английский

Citations

0
A case of congenital bronchial atresia with tracheobronchial stenosis caused by emphysema: Successful management with thoracoscopic surgery DOI Creative Commons

Huan Lin,

Sen Tian,

Chunlai Niu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e32753 - e32753

Published: June 1, 2024

Language: Английский

Citations

0
Pulmonary endoscopy – central to an interventional pulmonology program DOI

Sally Griffiths,

Lucy Power,

DAVID P BREEN

et al.

Expert Review of Respiratory Medicine, Journal Year: 2024, Volume and Issue: 18(11), P. 843 - 860

Published: Oct. 7, 2024

Introduction Pulmonary endoscopy occupies a central role in Interventional Pulmonology and is frequently the mainstay of diagnosis respiratory disease, particular lung malignancy. Older techniques such as rigid bronchoscopy maintain an important airway obstruction. Renewed interest peripheral pulmonary nodule driving major advances technologies to increase diagnostic accuracy advance new potential endoscopic therapeutic options.

Language: Английский

Citations

0