Comparison of diagnostic yield and safety of endobronchial ultrasound-guided mediastinal lymph nodal cryobiopsy and endobronchial ultrasound-guided Franseen tip needle biopsy DOI Creative Commons
Venkata Nagarjuna Maturu, Anand Vijay, Virender Pratibh Prasad

et al.

Monaldi Archives for Chest Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

In this prospective study, we evaluated the diagnostic yield and safety of two endobronchial ultrasound (EBUS) biopsy techniques – mediastinal cryobiopsy (EBUS-MCB) Franseen tip needle (EBUS-ANB) in patients with undiagnosed lymphadenopathy. The study included 30 who underwent both EBUS-MCB EBUS-ANB, four biopsies taken from each patient using methods. results demonstrated that provided a higher (96.4%) compared to EBUS-ANB (73.3%). Specimens showed fewer artifacts density granulomas were adequate for ancillary studies all cases. most common complication observed was minor bleeding, which more (36.6% versus 13.3%, p=0.04). This demonstrates EBUS-guided has when have an acceptable profile. Larger comparing these are necessary confirm findings current study.

Language: Английский

Rapid On‐Site Digital Histopatholocal Evaluation (RODE) on Endobronchial Ultrasound (EBUS) Mediastinal Lymph Node Cryobiopsy Sampling Using Confocal Laser Microscopy—A Proof‐Of‐Concept Study DOI Creative Commons
Hari Kishan Gonuguntla, Belgundi Preeti Vidyasagar,

Milap Shah

et al.

Respirology Case Reports, Journal Year: 2025, Volume and Issue: 13(2)

Published: Feb. 1, 2025

ABSTRACT The current standard for determining sample adequacy during Endobronchial Ultrasound guided Mediastinal Sampling is ROSE (Rapid on‐site Evaluation) on samples obtained by Fine needle Aspiration. There an increasing interest in Lymph node cryobiopsy, where tissue are using a 1.1 mm cryoprobe. Rapid onsite evaluation cryobiopsy can also be performed imprint cytology. This proof‐of‐concept study explores the use of Viva Scope 2500 rapid digital histopathological (EBUS) mediastinal lymph samples. Confocal Laser Microscopy allows high‐resolution imaging and expedites diagnosis. involved four cases were subjected to examination (confocal laser microscopy), enabling lesion tool confirmation results compared with final conventional histopathology results. microscopy was found comparable histopathology, superior providing diagnosis minimising time diagnosis, added advantage better sampled preservation downstream molecular analysis. RODE reduces procedural increases confidence operator sampling confirmation. alternative decreasing

Language: Английский

Citations

0
A Novel Procedure for Endobronchial Ultrasound-Guided Transbronchial Mediastinal Cryobiopsy with a Puncture Dilation Catheter DOI

Run Tong,

Mingming Deng, Ziwen Zheng

et al.

Respiration, Journal Year: 2024, Volume and Issue: 103(11), P. 701 - 706

Published: July 30, 2024

Introduction: Endobronchial ultrasound (EBUS)-guided transbronchial mediastinal cryobiopsy (TBMC) is increasingly used to diagnose lymphadenopathy. Various methods have been create a tunnel between the airway wall and lesions for this procedure, such as electrocautery penetration with sheath of needle EBUS-transbronchial fine aspiration. However, those are complex. Case Presentation: We developed new technique called EBUS-TBMC via tunnel, we it in four cases and/or hilar puncture dilation catheter target lymph node. The cryoprobe was introduced node cooled liquid carbon dioxide 5–9 s. probe subsequently pulled out samples complete tunnel. A definite diagnosis made based on pathological examination obtained all cases. After none patients experienced moderate severe bleeding, pneumothorax, pneumomediastinum, or other adverse events. Conclusion: feasible convenient procedure performance TBMC. Further studies required evaluate safety efficacy

Language: Английский

Citations

2
An explorative analysis on the optimal cryo-passes and freezing time of the ultrathin cryoprobe in endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy DOI Creative Commons
Sze Shyang Kho, Shirin Hui Tan, Chun Ian Soo

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 12, 2024

Abstract EBUS-guided transbronchial mediastinal cryobiopsy (TBMC) has emerged as a promising biopsy tool for diagnosing hilar and pathologies. However, several fundamental technical aspects of TBMC remain unexplored. This study aims to determine the optimal number cryo-passes freezing time ultrathin cryoprobe in EBUS-TBMC concerning specimen size procedural diagnostic yield. We conducted retrospective chart review patients with lesions who underwent between January 2021 April 2023 across three hospitals Malaysia. A total 129 procedures were successfully completed, achieving an overall yield 88.4%. Conclusive associated larger sizes (7.0 vs. 5.0 mm, p < 0.01). Specimen demonstrated positive correlation ( 0.01), plateauing at 4.1–6.0 mm. significant was also observed both 0.01) 0.05). Diagnostic plateaued after 2–3 cryo-passes. In contrast, longer times trended towards smaller specimens lower yield, though not reaching statistical significance. The highest recorded 3.1–4.0 s time. safety profile remains favourable, one case (0.8%) pneumothorax nine cases (7%) self-limiting bleeding. our cohort, performance achieve aggregate mm appeared optimal. Further prospective studies are needed validate these findings.

Language: Английский

Citations

2
Combination of cryobiopsy with EBUS-TBNA–Might rapid on-site evaluation successfully drive patient selection? DOI Creative Commons
Michele Mondoni,

Momen M. Wahidi,

Giovanni Sotgiu

et al.

Pulmonology, Journal Year: 2024, Volume and Issue: 30(5), P. 416 - 418

Published: March 27, 2024

Language: Английский

Citations

2
Endobronchial ultrasound‐guided cryobiopsy for diagnosing a case of granulomatosis with polyangiitis DOI Creative Commons
Teresa Calari, Simone Petrarulo,

Alessandra Dubini

et al.

Respirology Case Reports, Journal Year: 2024, Volume and Issue: 12(5)

Published: May 1, 2024

EBUS-TBNA has represented a revolution in the diagnosis of intrathoracic pathologies, particularly lung cancer staging, replacing more invasive methods such as mediastinoscopy. However, its role diagnosing rare benign or malignant mediastinal disorders is still matter debate. Over past few years, EBUS-guided cryobiopsy been increasingly emerging an innovative and minimally technique these disorders, with excellent safety profile. In this case report, we present young man brought to our attention after already undergoing non-diagnostic trans thoracic needle aspiration (TTNA) procedure for consolidations. department, he underwent initial inconclusive rapid on-site evaluation (ROSE), leading decision perform cryobiopsy, which yielded granulomatosis polyangiitis without complications. This clinical demonstrates that specific contexts, EBUS-cryobiopsy represents diagnostic tool.

Language: Английский

Citations

2
The utility of endobronchial ultrasound‐guided transbronchial mediastinal cryobiopsy (EBUS‐TBMC) for the diagnosis of mediastinal lymphoma DOI Creative Commons
Nai‐Chien Huan,

Wei Lun Lee,

Hema Yamini Ramarmuty

et al.

Respirology Case Reports, Journal Year: 2024, Volume and Issue: 12(4)

Published: April 1, 2024

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a revolutionary tool for the diagnosis and staging of mediastinal disorders. Nevertheless, its diagnostic capability reduced in certain disorders such as lymphoproliferative diseases. EBUS-guided cryobiopsy (EBUS-TBMC) novel technique that can provide larger samples with preserved tissue architecture, an acceptable safety profile. In this case report, we present middle-aged gentleman huge anterior mass bilateral hilar lymphadenopathy. He underwent EBUS-TBNA rapid on-site evaluation (ROSE) followed by EBUS-TBMC, all under general anaesthesia. Histopathological analysis showed discordance between EBUS-TBMC which only TBMC provided adequate to attain primary large B-cell lymphoma. This report reinforced role

Language: Английский

Citations

1
Feasibility and safety of transesophageal mediastinal cryobiopsy in the diagnosis of mediastinal pathologies DOI
Sammy Onyancha,

Emilia Nitsch,

Nesrin Tekeli-Camcı

et al.

Respiration, Journal Year: 2024, Volume and Issue: 103(11), P. 686 - 691

Published: Aug. 22, 2024

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration remains the gold standard for diagnosis of mediastinal pathologies. Its greatest limitation has been low diagnostic yield in lymphoproliferative disorders as well insufficient samples molecular testing. Transesophageal examinations using an EBUS scope have helped increase by allowing additional biopsies paraesophageal and intra-abdominal lesions. Similarly, novel approach cryobiopsy further increased providing larger better-preserved biopsies. Both complimentary techniques shown great individual feasibility safety. However, transesophageal cryobiopsies evaluation pathologies a subject debate. Aim: The aim study was to investigate safety EBUS-guided performed at our center. Methods: We conducted retrospective review 30 patients who underwent through esophagus institution between October 2023 March 2024. Data on patient demographics, yield, complications were collected analyzed. Results: mean age 43 years, with gender distribution 60% male 40% female. primary indications included suspicion disorders, suspected sarcoidosis, malignancies overall 93%. No major noted any patients. Conclusion: appears be promising technique relatively high favorable profile. studies cohorts are warranted validate findings institution.

Language: Английский

Citations

1
Minimally Invasive Sampling of Mediastinal Lesions DOI Creative Commons
Alberto Fantin, Nadia Castaldo, Ernesto Crisafulli

et al.

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1291 - 1291

Published: Oct. 11, 2024

This narrative review examines the existing literature on minimally invasive image-guided sampling techniques of mediastinal lesions gathered from international databases (Medline, PubMed, Scopus, and Google Scholar). Original studies, systematic reviews with meta-analyses, randomized controlled trials, case reports published between January 2009 November 2023 were included. Four authors independently conducted search to minimize bias, removed duplicates, selected evaluated studies. The focuses recent advancements in techniques, including EBUS-TBNA, EUS-FNA FNB, IFB, nodal cryobiopsy. highlights advantages an integrated approach using these for diagnosing staging diseases, which, when used competently, significantly increase diagnostic yield accuracy.

Language: Английский

Citations

1
EBUS-Guided Transbronchial Mediastinal Cryobiopsy: A Novel Technique for Diagnosing Mediastinal Lesions—Single-Center Experience DOI

Márcia Araújo,

Luís Vaz Rodrigues,

Paulo Matos

et al.

Archivos de Bronconeumología, Journal Year: 2024, Volume and Issue: 60(9), P. 593 - 594

Published: Sept. 1, 2024

Language: Английский

Citations

0
Quality standards for cryobiopsy DOI Creative Commons

Arianna Johanna De Grauw,

Claudia Ravaglia, Venerino Poletti

et al.

Barcelona Respiratory Network, Journal Year: 2024, Volume and Issue: 10(2)

Published: June 18, 2024

Transbronchial cryobiopsy (TBLC) is a technique on the rise in diagnostic workup of diffuse interstitial lung diseases (DPLD), recently being included European Respiratory Society Guidelines as an acceptable alternative to surgical biopsy (SLB), which had thus far been considered gold standard.In this article, we review what known optimize procedure, including patient selection, contraindications, possible complications and transbronchial technique.

Language: Английский

Citations

0