Oxygen comfort evaluation method based on symptom index for short-term internal migrants to Tibet

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 902, P. 166418 - 166418

Published: Aug. 20, 2023

Language: Английский

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Acute mountain sickness on Jade Mountain: Results from the real-world practice (2018–2019)

Journal of the Formosan Medical Association, Journal Year: 2024, Volume and Issue: 123(11), P. 1161 - 1166

Published: Feb. 7, 2024

Acute mountain sickness (AMS) is initiated in response to a hypoxic and hypobaric environment at high altitude. The precise prevalence of AMS Jade Mountain climbers remained largely unknown, particularly data obtained from real medical consultations. An overnight stay the Pai-Yun Lodge (3402 m) usually required before an ascent Mountain. Since 2004, Clinic has been established Lodge. provided regular emergency service every weekend. We conducted retrospective study by using records between 2018 2019. A total 1021 patients were enrolled, with 56.2 % males. Different age groups 3.2 %, 54.5 37.9 4.4 <20, 20−39, 40−59, ≥60 years, respectively. There 582 (57.0 %) diagnosed have (230 [39.5 %] mild type 352 [60.5 severe type). factors associated development included young age, absence climbing history (>3000 within last 3 months, first experience, taking preventive medication, low oxygen saturation, Lake Louise score (LLAMSS). severity LLAMSS. Approximately 15 needed service, which 60 had AMS. must require supply or medication prescription. Oxygen saturation measure LLAMSS evaluation are reasonable tools predict occurrence on

Language: Английский

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Mountain sickness in altitude inhabitants of Latin America: A systematic review and meta-analysis

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(9), P. e0305651 - e0305651

Published: Sept. 24, 2024

Objective Chronic and acute mountain sickness is known worldwide, but most of the available information comes from eastern continent (Himalayas) without taking into account west which has recent group located at altitude, Andes. The aim this study was to synthesize evidence on prevalence chronic in Latin American countries (LATAM). Methods A systematic search variables interest performed until July 8, 2023 Web Science, Scopus, PubMed Embase databases. We included studies that assessed high-altitude inhabitants (>1500 m.a.s.l) who lived a place more than 12 months. These were analyzed by means meta-analysis proportions. To assess sources heterogeneity, subgroup analyses sensitivity including only with low risk bias excluding extreme values (0 or 10,000 ratio). PROSPERO (CRD42021286504). Results Thirty-nine cross-sectional (10,549 participants) met inclusion criteria. identified 5 334 2 945 events out LATAM countries. common physiological alteration polycythemia (2,558 events), while cerebral edema less (46 events). Clinical conditions prevalent high altitudes for both types MS. Conclusion Acute (AMS) occurs approximately 10 people (CMS) 3 10. frequent least edema.

Language: Английский

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Research Progress on Using Nanoparticles to Enhance the Efficacy of Drug Therapy for Chronic Mountain Sickness

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1375 - 1375

Published: Oct. 26, 2024

Chronic mountain sickness (CMS) poses a significant health risk to individuals who rapidly ascend high altitudes, potentially endangering their lives. Nanoparticles (NPs) offer an effective means of transporting and delivering drugs, protecting nucleic acids from nuclease degradation, mediating the expression target genes in specific cells. These NPs are almost non-toxic easy prepare store, possess large surface area, exhibit good biocompatibility degradability, maintain stability. They can be utilized treatment CMS enhance therapeutic efficacy drugs. This paper provides overview impact on CMS, discussing roles as nanocarriers potential treatment. It aims present novel strategies for clinical management summarizes relevant pathways through which contribute plateau disease treatment, providing theoretical foundation future research.

Language: Английский

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Altitude adaptation: The unseen work of gut microbiota

hLife, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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High altitude is associated with pTau deposition, neuroinflammation, and myelin loss

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: April 27, 2022

Mammals are able to adapt high altitude (HA) if appropriate acclimation occurs. However, specific occupations (professional climbers, pilots, astronauts and other) can be exposed HA without at a higher risk of brain consequences. In particular, US Air Force U2-pilots have been shown develop white matter hyperintensities (WMH) on MRI. Whether WMH due hypoxia or hypobaria effects is not understood. We compared swine brains 5000 feet (1524 m) above sea level (SL) with 21% fraction inspired O2 (FiO2) (Control group [C]; n = 5) vs. 30,000 (9144 SL 100% FiO2 (hypobaric [HYPOBAR]; 6). performed neuropathologic assessments, molecular analyses, immunohistochemistry (IHC), Western Blotting (WB), stereology analyses detect differences between HYPOBAR Controls. Increased neuronal insoluble hyperphosphorylated-Tau (pTau) accumulation was observed across different regions, histological level, in the Stereology-based cell counting demonstrated significant difference (p < 0.01) pTau positive neurons C Hippocampus. Higher levels soluble Hippocampus Controls were also detected by WB analyses. Additionally, an increase IBA-1 Cerebellum decrease myelin basic protein (MBP) These findings illustrate, for first time, changes occurring large mammalian after exposure nonhypoxic-hypobaria open new pathophysiological views interaction among hypobaria, accumulation, neuroinflammation, myelination mammals HA.

Language: Английский

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Assessment of Cardiovascular Injury Induced by Plateau Environment in Rats: A Comprehensive Analysis of Clinical and Perfusion Indices

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(04), P. 2181 - 2190

Published: Jan. 1, 2024

Language: Английский

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Embarazo crítico en la altitud: una mirada en América Latina

Medicina Intensiva, Journal Year: 2024, Volume and Issue: 48(7), P. 411 - 420

Published: May 1, 2024

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Critical pregnancy at altitude: A look at Latin America

Medicina Intensiva (English Edition), Journal Year: 2024, Volume and Issue: 48(7), P. 411 - 420

Published: May 3, 2024

Language: Английский

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Incidence and risk factors of acute mountain sickness during ascent to Hoh Xil and the physiological responses before and after acclimatization

Turkish Journal of Emergency Medicine, Journal Year: 2024, Volume and Issue: 24(4), P. 226 - 230

Published: Oct. 1, 2024

Abstract OBJECTIVES: Ascending to altitudes >2500 m may lead acute mountain sickness (AMS). METHODS: The demographics, height, weight, body mass index (BMI), smoking, and alcohol consumption of 104 healthy controls were collected in Chengdu (500 m). Heart rate (HR), saturation pulse oxygen (SpO2), AMS-related symptoms Hoh Xil (4200 A headache with Lake Louise score ≥3 was defined as AMS. RESULTS: incidence AMS 60.58%. group had a lower SpO2 higher HR than non-AMS group. Alcohol seemed risk factor for There no difference the BMI, age, smoking between groups. most common symptom headache, followed by dyspnea, insomnia, dizziness, lassitude, anorexia. Women prone suffer from dizziness. value improved both groups after hypoxia acclimatization, showed greater improvement Oxygen therapy decreased AMS-induced tachycardia, which any effect on alleviating time. CONCLUSION: Lower following exposure high altitude associated susceptibility. anthropometric data changes larger before acclimatization.

Language: Английский

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