Comparative Efficacy of Different Drugs for the Treatment of Dilated Cardiomyopathy: A Systematic Review and Network Meta-analysis DOI Creative Commons
Xinyu Tong, Lijuan Shen, Xiaomin Zhou

et al.

Drugs in R&D, Journal Year: 2023, Volume and Issue: 23(3), P. 197 - 210

Published: Aug. 9, 2023

At present, the therapies of dilated cardiomyopathy concentrated on symptoms heart failure and related complications. The study is to evaluate clinical efficacy a combination various conventional adjuvant drugs in treating via network meta-analysis. was reported according PRISMA 2020 statement. From inception through 27 June 2022, PubMed, Embase, Cochrane library, Web Science databases were searched for randomized controlled trials medicines cardiomyopathy. quality included studies evaluated risk bias assessment. R4.1.3 Revman5.3 software used analysis. There 52 this study, with total 25 medications sample size 3048 cases. meta-analysis found that carvedilol, verapamil, trimetazidine top three improving left ventricular ejection fraction (LVEF). Ivabradine, bucindolol, verapamil 3 end-diastolic dimension (LVEDD). l-thyroxine, atorvastatin end-systolic (LVESD). Trimetazidine, pentoxifylline, bucindolol New York Heart Association classification (NYHA) cardiac function score. reducing rate (HR). A different therapy may increase effectiveness Beta-blockers, especially can improve remodeling, function, patients (DCM). Hence, they be if tolerate them. If LVEF HR do not meet standard, ivabradine also other treatments. However, since number our research limited, large size, multi-center, high-quality are required corroborate findings.

Language: Английский

Sodium-glucose cotransporter 2 inhibitors induce anti-inflammatory and anti-ferroptotic shift in epicardial adipose tissue of subjects with severe heart failure DOI Creative Commons
Barbora Judita Kasperová, Miloš Mráz, Petr Svoboda

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 28, 2024

Abstract Background Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) are glucose-lowering agents used for the treatment of type diabetes mellitus, which also improve heart failure and decrease risk cardiovascular complications. Epicardial adipose tissue (EAT) dysfunction was suggested to contribute development failure. We aimed elucidate a possible role changes in EAT metabolic inflammatory profile beneficial cardioprotective effects SGLT-2i subjects with severe Methods 26 failure, reduced ejection fraction, treated versus without treatment, matched age (54.0 ± 2.1 vs. 55.3 years, n.s.), body mass index (27.8 0.9 28.8 1.0 kg/m , n.s.) left ventricular fraction (20.7 0.5 23.2 1.7%, who were scheduled transplantation or mechanical support implantation, included study. A complex metabolomic gene expression analysis obtained during surgery performed. Results ameliorated inflammation, as evidenced by improved pro-inflammatory genes decreased infiltration immune cells into EAT. Enrichment ether lipids oleic acid noted on suggests disposition ferroptosis, potentially further contributing oxidative stress subjects. Conclusions Our results show inflammation patients SGLT-2i, compared this therapy. Modulation status could represent novel mechanism behind SGLT-2i-associated

Language: Английский

Citations

8
Obesity and cardiovascular disease: risk assessment, physical activity, and management of complications DOI Creative Commons
Francesco Perone, Luigi Spadafora, Alessandra Pratesi

et al.

International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2024, Volume and Issue: 23, P. 200331 - 200331

Published: Sept. 6, 2024

The patient with obesity is at risk of developing cardiovascular disease and factors. Obesity negatively impacts prognosis increases morbidity mortality. Therefore, a comprehensive assessment needed to define the and, thus, tailored management treatment. Chronic successful these patients involves evaluation various therapeutic strategies available (comprehensive lifestyle intervention, weight-loss medications, bariatric surgery) diagnosis treatment complications (coronary artery disease, heart failure, atrial fibrillation). Cardiac rehabilitation in showing beneficial effect positive impact on weight loss, factors, mental health, functional capacity, adherence interventions pharmacological Long-term loss maintenance represent key objective during reduce future adverse events. Multidisciplinary are necessary prevent overall aim our review propose comprehensive, critical updated overview regarding assessment, physical activity, obesity.

Language: Английский

Citations

8
Omecamtiv Mecarbil in the treatment of heart failure: the past, the present, and the future DOI Creative Commons

Shujing Zhou,

Ying Liu, Xufeng Huang

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: March 19, 2024

Heart failure, a prevailing global health issue, imposes substantial burden on both healthcare systems and patients worldwide. With an escalating prevalence of heart prolonged survival rates, aging demographic, increasing number individuals are progressing to more advanced phases this incapacitating ailment. Against backdrop, the quest for pharmacological agents capable addressing diverse subtypes failure becomes paramount pursuit. From viewpoint, present article focuses Omecamtiv Mecarbil (OM), emerging chemical compound said exert inotropic effects without altering calcium homeostasis. For first time, as review, uniquely started from very basic pathophysiology its classification, strategies underpinning drug design, on-going debates OM's underlying mechanism action latest large-scale clinical trials. Furthermore, we not only saw advantages OM, but also exhaustively summarized concerns in sense effects. These no doubt make most systemic informative one among existing literature. Overall, by offering new mechanistic insights therapeutic possibilities, OM has carved significant niche treatment making it compelling subject study.

Language: Английский

Citations

6
Boundary attention with multi-task consistency constraints for semi-supervised 2D echocardiography segmentation DOI
Yiyang Zhao, Kangla Liao, Yineng Zheng

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 171, P. 108100 - 108100

Published: Feb. 5, 2024

Language: Английский

Citations

5
Clinical Update in Heart Failure with Preserved Ejection Fraction DOI
Chayakrit Krittanawong,

William Britt,

Affan Rizwan

et al.

Current Heart Failure Reports, Journal Year: 2024, Volume and Issue: 21(5), P. 461 - 484

Published: Sept. 3, 2024

Language: Английский

Citations

5
Assessment of filling pressures and fluid overload in heart failure: an updated perspective DOI
Rafael de la Espriella, Marta Cobo Marcos, Enrique Santas

et al.

Revista Española de Cardiología (English Edition), Journal Year: 2022, Volume and Issue: 76(1), P. 47 - 57

Published: Aug. 4, 2022

Language: Английский

Citations

22
Global, regional and national estimates of influenza-attributable ischemic heart disease mortality DOI Creative Commons
Sandra S. Chaves, Joshua Nealon, Katrin Burkart

et al.

EClinicalMedicine, Journal Year: 2022, Volume and Issue: 55, P. 101740 - 101740

Published: Nov. 18, 2022

Influenza virus infection is associated with incident ischemic heart disease (IHD) events. Here, we estimate the global, regional, and national IHD mortality burden attributable to influenza.We used vital registration data from deaths in adults ≥50 years (13.2 million as underlying cause) assess relationship between influenza activity a non-linear meta-regression framework 2010 2019. This derived was then global mortality. We estimated population fraction (PAF) of for based on relative risk given level weekly test positivity rate multiplied PAFs by Global Burden Disease study.Influenza increased across all countries analyzed. The mean PAF 3.9% (95% uncertainty interval [UI] 2.5-5.3%), ranging <1% 10%, depending country year. Globally, 299,858 UI 191,216-406,809) could be attributed influenza, highest rates per 100,000 Central Europe, Eastern Europe Asia Region (32.3; 95% 20.6-43.8), North Africa Middle East (26.7; 17-36.2).Influenza may contribute substantially IHD. Our results suggest that if there were no an average 4% globally would not occur.Collaborative study funded Sanofi Vaccines.

Language: Английский

Citations

22
Incremental prognostic value of left atrial strain in patients with heart failure DOI Creative Commons

Kairui Bo,

Yifeng Gao, Zhen Zhou

et al.

ESC Heart Failure, Journal Year: 2022, Volume and Issue: 9(6), P. 3942 - 3953

Published: Aug. 11, 2022

The present study aimed to evaluate the prognostic value of atrial strain and rate (SR) parameters derived from cardiac magnetic resonance (CMR) feature tracking (FT) in patients with ischaemic non-ischaemic dilated cardiomyopathy heart failure reduced ejection fraction (HFrEF) but without fibrillation.

Language: Английский

Citations

19
Renal and Cardiovascular Metabolic Impact Caused by Ketogenesis of the SGLT2 Inhibitors DOI Open Access
Ariana P. Vargas-Delgado, Estefania Arteaga Herrera, Cesar Tumbaco Mite

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4144 - 4144

Published: Feb. 18, 2023

Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) are glycosuric drugs that were originally developed for the treatment of diabetes mellitus (T2DM). There is a hypothesis SGLT2i capable increasing ketone bodies and free fatty acids. The idea they could serve as necessary fuel, instead glucose, purposes cardiac muscle requirements explain antihypertensive effects, which independent renal function. adult heart, under normal conditions, consumes around 60% to 90% energy derived from oxidation In addition, small proportion also comes other available substrates. order meet demands with respect achieving adequate function, heart known possess metabolic flexibility. This allows it switch between different substrates in obtain molecule adenosine triphosphate (ATP), thereby rendering highly adaptive. It must be noted oxidative phosphorylation aerobic organisms main source ATP, result reduced cofactors. These cofactors include nicotine adenine dinucleotide (NADH) flavin (FADH2), electron transfer used enzymatic involved respiratory chain. When there an excessive increase nutrients-such glucose acids-which occur absence parallel demand, state nutrient surplus (which better excess supply) created. use at level has been shown generate beneficial alterations, obtained by reducing glucotoxicity induced glycosuria. Together reduction perivisceral fat various organs, such alterations lead acids initial stages affected heart. Subsequently, this results production ketoacids, more fuel cellular level. even though their mechanism not fully understood, vast benefits render them incredible importance further research.

Language: Английский

Citations

12
GUIDELINE-DIRECTED MEDICAL THERAPY FOR HEART FAILURE: REAL-WORLD EVIDENCE IN ONE LATIN-AMERICAN CENTER DOI Creative Commons
Javier Torres-Jiménez, Lucas Restrepo,

Manuela Villa

et al.

Current Problems in Cardiology, Journal Year: 2025, Volume and Issue: unknown, P. 102990 - 102990

Published: Jan. 1, 2025

Language: Английский

Citations

0